Blood flow, cerebral

Among the examples of monoindole bases being discussed, vincamine (109) is the principal alkaloid of Vinca minorC. and has received some notoriety because it apparently causes some improvement in the abiUties of sufferers of cerebral arteriosclerosis (78). It is beheved that this is the result of increasing cerebral blood flow with the accompanying increase in oxygenation of tissue as a result of its action as a vasodilator. [Pg.551]

In other applications of CT, orally administered barium sulfate or a water-soluble iodinated CM is used to opacify the GI tract. Xenon, atomic number 54, exhibits similar x-ray absorption properties to those of iodine. It rapidly diffuses across the blood brain barrier after inhalation to saturate different tissues of brain as a function of its lipid solubility. In preliminary investigations (99), xenon gas inhalation prior to brain CT has provided useful information for evaluations of local cerebral blood flow and cerebral tissue abnormalities. Xenon exhibits an anesthetic effect at high concentrations but otherwise is free of physiological effects because of its nonreactive nature. [Pg.469]

Vascular dementia (VD) accounts for 20-30% of dementia cases, with clinical and pathological overlap with AD. Reductions in cholinergic markers suggest cholinergic deficits in VD, and ChEIs increase ACh availability and improve their cerebral blood flow. [Pg.360]

Brain imaging technique that allows visualization of the brain, in order to understand which brain regions are involved in specific functions. Its functioning is based on the measurement of the regional cerebral blood flow which increases when a specific brain region is activated. Its use is similar to that of positron emission tomography (PET). [Pg.511]

Cerebral blood flow Piracetam, hydergine Study findings have been negative. [Pg.196]

Holman BL, Mendelson J, Garada B, er al Regional cerebral blood flow improves wirh treatment in chronic cocaine polydrug users. J Nucl Med 34 723—727, 1993... [Pg.204]

A. C. Evans, M. Diksic, Y. L. Yamamoto, A. Kato, A. Dagher, C. Redies, and A. Hakim, J. Cerebr. Blood Flow Metab., 6 (1986) 724-738 related references on the rate constants are cited therein. [Pg.187]

H. Sasaki, I. Kanno, M. Murakami, F. Shishido, and K. Uemura, J. Cerebr. Blood Flow... [Pg.187]

Cenic A, Nabavi DG, Craen RA, Gelb AW, Lee TY. Dynamic CT measurement of cerebral blood flow a validation study. Am J Neuroradiol 1999 20 63-73. [Pg.33]

Wintermark M, Thiran JP, Maeder P, Schnyder P, Meuli R. Simultaneous measurement of regional cerebral blood flow by perfusion CT and stable xenon CT a validation study. Am J Neuroradiol 2001 22 905-914 [see comment]. [Pg.33]

Rempp KA, Brix G, Wenz F, Becker CR, Guckel F, Lorenz WJ. Quantification of regional cerebral blood flow and volume with dynamic susceptibility contrast-enhanced MR imaging. Radiology 1994 193 637-641. [Pg.33]

Hagen T, Bartylla K, Piepgras U. Correlation of regional cerebral blood flow measured by stable xenon CT and perfusion MRI. J Comput Assist Tomogr 1999 23 257-264. [Pg.33]

Lin W, Celik A, Derdeyn C, An H, Lee Y, Videen T, Qstergaard L, Powers WJ. Quantitative measurements of cerebral blood flow in patients with unilateral carotid artery occlusion a PET and MR study. J Magn Reson Imaging 2001 14 659-667. [Pg.33]

Sorensen AG, Copen WA, 0stergaard L, Buonanno FS, Gonzalez RG, Rordorf G, Rosen BR, Schwamm LH, Weisskoff RM, Koroshetz WJ. Hyperacute stroke simultaneous measurement of relative cerebral blood volume, relative cerebral blood flow, and mean tissue transit time. Radiology 1999 210 519-527. [Pg.34]

Parsons MW, Yang Q, Barber PA, Darby DG, Desmond PM, Gerraty RP, Tress BM, Davis SM. Perfusion magnetic resonance imaging maps in hyperacute stroke relative cerebral blood flow most accurately identifies tissue destined to infarct. Stroke 2001 32 1581-1587. [Pg.34]

Perlmutter JS, Powers WJ, Herscovitch R Fox PT, Raichle ME. Regional asymmetries of cerebral blood flow, blood volume, and oxygen utilization and extraction in normal subjects. J Cereb Blood Flow Metab 1987 7 64-67. [Pg.36]

Wintermark M, Reichhart M, Thiran JP, Maeder P, Chalaron M, Schnyder P, Bogous-slavsky J, MeuU R. Prognostic accuracy of cerebral blood flow measurement by perfusion computed tomography, at the time of emergency room admission, in acute stroke patients. Ann Neurol 2002 51 417-432. [Pg.36]

Decreased cerebral blood flow, resulting from acute arterial occlusion, reduces oxygen and glucose delivery to brain tissue with subsequent lactic acid production, blood-brain barrier breakdown, inflammation, sodium and calcium pump dysfunction, glutamate release, intracellular calcium influx, free-radical generation, and finally membrane and nucleic acid breakdown and cell death. The degree of cerebral blood flow reduction following arterial occlusion is not uniform. Tissue at the... [Pg.39]

Grandin CB, Duprez TP, Smith AM, Mataigne F, Peeters A, Oppenheim C, Cosnard G. Usefulness of magnetic resonance-derived quantitative measurements of cerebral blood flow and volume in prediction of infarct growth in hyperacute stroke. Stroke. 2001 32 1147-1153. [Pg.55]

Chi OZ, Poliak P, Weiss HR. Effects of magnesium sulfate and nifedipine on regional cerebral blood flow during middle cerebral artery ligation in the rat. Arch Int Pharma-codyn Ther 1990 304 196-205. [Pg.117]

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