PET Positron-emission

In 2003 LJngstrOm and Samuelsson described the synthesis of a radiopharmaceutical for PET (positron emission tomography) using a microwave-assisted Stille reaction [25]. l-(2 -Deoxy-2 -fluoro- 6-D-arabinofuranosyl)-... 

PET Positron-emission tomography REM Rapid eye movement recent event memory... 

PET positron emission tomography RME receptor-mediated endocytosis... 

Nuclear medicine is used chiefly in medical diagnosis. A radiopharmaceutical—a relatively harmless compound with a low dose of radiation— is swallowed or injected into the patient and tracked through the bloodstream by instruments such as a PET (positron emission tomography) camera. The nuclear physician can use the results to create a... 

PET positron emission tomography, IV intravenous, nic nicotine, ACC anterior cingulate cortex, occ ctx occipital cortex, PFC prefrontal cortex, thal thalamus,/Mf / functional magnetic resonance imaging... 

PET positron emission tomography, /V intravenous, nic nicotine, DV volume of distribution, DA dopamine. cd caudate, put putamen, SPEC single photon emission computed tomography, DAT dopamine transporter, p-CTT 2 p-catbomethoxy-3 p-(4-iodophenyl)-tropane, 5-HT serotonin... 

The radioisotope nitrogen-13 has a relatively short half-life of about 10 minutes that produces a positron as it decays. This makes N-13 useful in PET (Positron Emission Tomography) scan technology, in which it is injected into the patient. The positive electrons (positrons) interact with the patient s negative electrons to produce an image similar to an X-ray. 

C]-Zanamivir (2) was also synthesized with a C-label on the guanidino group for use in PET (positron emission tomography) studies by treating 87 with [ C]-cyanogen bromide followed by treatment of the intermediate cyanamide with a solution of aqueous ammonium hydroxide and ammonium chloride (Westerberg et al., 1996). 

Most of the fluoro derivatives of proline described in the literature are fluorinated in the 4 position. 4-Fluoroprolines are able to mimic 4-hydroxyproline, present in some proteins and polypeptides. On the other hand, 4-fluorination could suppress oxidative metabolism or modified ring conformation of ligands.The labeled analogues may be used as probes in PET (positron emission tomography) for localization of tumors... 

AN, anorexia nervosa BN-AN, bulimia nervosa-anorexia nervosa, fMRI, functional magnetic resonance imaging PET, positron emission tomography rec, recovered SPECT, single photon emission computed tomography. 

Figure 9 Effect of cyclosporin A on the brain (A) and plasma (B) concentration of nC verapamil in healthy volunteers. (A) 1 -Verapamil ( 0.2 mCi/kg) was administered to healthy volunteers intravenously, approximately one minute before and after one-hour infusion of cyclosporin A (2.5 mg/kg/h). (B) PET images of a normal human brain after nC-verapamil administration in the absence or presence of cyclosporin A. Images shown are in SUV summed over a period of 5 to 25 minutes, which is an index of regional radioactivity uptake normalized to the administered dose and weight of the subject. Abbreviations PET, positron emission tomography SUV, standardized uptake value. Source From Ref. 218.

Distribution in vivo could be studied by positron emission tomography (PET). Positron emission tomography is a sensitive and specific functional non invasive 3-D imaging method that permits rapidly and directly measurement of the total radioactivity from a drug labelled with a positron-emitting radionuclide (Gupta). 

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