Cerebral blood flow alcoholism

Alhassoon, O.M., Dupont, R.M., Schweinsburg, B.C., et al. Regional cerebral blood flow in cocaine-versus methamphetamine-dependent patients with a history of alcoholism. Int. J. Neuropsychopharmacol. 4 105, 2001. 

Volkow, N.D.. Mullani. N.. Gould. L., et ah Effects of acute alcohol intoxication on cerebral blood flow measured by PET. Psychiatry Res. 24(2), 201-209, 1988. 

Fulminant liver failure results from massive necrosis of liver tissue. Diminution of mental function results, and this often leads to coma. The body undergoes a buildup of toxic products, alteration of its acid balance, and a decrease in cerebral blood flow. Impaired blood coagulation and intestinal bleeding occur as well. Other malfunctions and diseases of the liver include viral infections and alcoholic hepatitis. In 1999, of the 14,707 individuals on a waiting list for transplants, 4,498 received transplants and 1,709 died while waiting. As of February 2002, 18,434 people awaited liver transplants. 

Kosten TR, Cheeves C, Palumbo J, Seibyl JP, Price LH, Woods SW. Regional cerebral blood flow during acute and chronic abstinence from combined cocaine-alcohol abuse. Drug Alcohol Depend 1998 50(3) 187-95. 

Compared with controls, recent cocaine abusers had significantly reduced cerebral blood flow in 11 of 14 brain regions, with the largest reductions in the frontal cortex and parietal cortex and greater cerebral blood flow in the brain stem. These perfusion defects appeared to be primarily due to combined abuse of alcohol and cocaine. Frontal but not parietal defects appeared to resolve partially during 21 days of abstinence. 

Heming, R. 1., Tate, K. Y, Better, W., and Cadet, J. L. (2002) Cerebral blood flow pulsatility deficits in H1V+ poly substance abusers Differences associated with antiyiral medications,. Drug Alcohol Depend. 65, 129-135. 

Ethanol-related cognitive deficits in the absence of Wernicke s encephalopathy also improve with extended abstinence. Most functional neuroimaging studies of abstinent alcoholics have shown decreases in both cerebral glucose metabolism and blood flow, with the decreases being greatest in the frontal lobes (Netrakom et ah, 1999). 

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