Cephalothin sodium salt

Cephalothin is the generic name for 7-(thiophene-2-acetamido)cephalosporanic acid cephalothin, sodium salt, Keflin, Lilly. 

In some related work, the same authors reported on the preparation of C-10 alkoxy derivatives via a 3-methylenecepham intermediate (Ochiai etai, 1972c). First, 2-[4-carboxy-7-(thiophene-2-acetamido)-3-cephem-3-yl-methylthio]-pyridineN-oxide (10) was prepared by displacement of the C-10 acetoxy group in cephalothin sodium salt by 2-pyridinethiol N-... 

Incompatibilities Do not mix IV minocycline before or during administration with any solutions containing the following Adrenocorticotropic hormone (ACTH), aminophylline, amobarbital sodium, amphotericin B, bicarbonate infusion mixtures, calcium gluconate or chloride, carbenicillin, cephalothin sodium, cefazolin sodium, chloramphenicol succinate, colistin sulfate, heparin sodium, hydrocortisone sodium succinate, iodine sodium, methicillin sodium, novobiocin, penicillin, pentobarbital, phenytoin sodium, polymyxin, prochlorperazine, sodium ascorbate, sulfadiazine, sulfisoxazole, thiopental sodium, vitamin K (sodium bisulfate or sodium salt), whole blood. 

The polarographic reductions of cephaloridine, cephalothin, and cephalosporin C each yield one wave that is both pH and concentration dependent [126]. The reduction of these compounds and a related derivative, 3-(5-methyl-1,3,4-thiadiazol-2-ylthiomethyl)-7-[2-(3-sydnone)acetamido]-3-cephem-4-carboxylic acid-sodium salt [I], have been described [127]. The reduction of I yields two waves. The first is believed to be the two-electron reductive elimination of the... 

Heparin and its salts are incompatible with many drugs including alteplase, amikacin sulfate, amiodarone hydrochloride, ampicillin sodium, aprotinin, benzylpenicillin potassium or sodium, cephalothin sodium, ciprofloxacin lactate, cytarabine, dacarbazine, daunorubicin hydrochloride, diazepam, dobutamine hydrochloride, doxorubicin hydrochloride, droperidol, erythromycin lactobionate, gentamicin sulfate, haloperidol lactate, hyaluronidase, hydrocortisone sodium succinate, kanamycin sulfate, methicillin sodium, netilmicin sulfate, some opioid analgesics, oxytetracycline hydrochloride, some phenothiazines, polymyxin B sulfate, streptomycin sulfate, tetracycline hydrochloride, tobramycin sulfate, vancomycin hydrochloride, vinblastine sulfate, cisatracurium besylate, labetalol hydrochloride, nicardipine hydrochloride, cefmetazole, sodium ions, and fat emulsion.110 112... 

Prochlorperazine Edisylate Prochlorperazine edisylate is not compatible with sodium chloride solutions containing methyl hydroxybenzoate and propyl hydroxy-benzoate as preservatives, but is compatible with solutions containing benzyl alcohol. Prochlorperazine edisylate salts are incompatible with a number of drugs such as aminophylline, amphotericin, ampicillin sodium, some barbiturates, ben-zylpenicillin salts, calcium gluconate, cefmetazole sodium, cephalothin sodium, chloramphenicol sodium succinate, chlorothiazide sodium, chloramphenicol, morphine sulfate containing phenol, magnesium trisilicate mixture, sodium succinate, chlorothiazide sodium, dimenhydrinate, heparin sodium, hydrocortisone sodium succinate, midazolam hydrochloride, and some sulfonamides.166... 

Cephapirin Sodium, Sterile, USP. Cephapirin (Cefa-dyl) is a scmisynthctic 7-ACA derivative released in the United States in 1974. It closely resembles ccphalothin in chemical and phannacokinetic properties. Like cephalothin, cephapirin is unstable in acid and must be administered par-enterally in the form of an aqueous solution of the. sodium salt. It is moderately protein bound (45 to 50%) in plasma and cleared rapidly by the kidneys. Cephapirin and cephalothin arc very similar in antimicrobial spectrum and potency. Conflicting reports concerning the relative tK-currence of pain at the site of injection and thrombophlebitis after intravenous injection of cephapirin and cephalothin are dirTicuIt to as.sess on the basis of available clinical data. 

Cephalothin is 3(Hydroxymethyl)-8-oxo-7-[2-(2-thienyl)-acetamido]-5-thia-l-azabicyclo [. 2.0]oct-2-ene-2-carboxylic acid acetate, and is also known as 7-(2-thienylacetamido) cepha-losporanic acid. The antibiotic is supplied as the sodium salt. 

On electron impact in the mass spectrometer, the sodium salt of cephalothin did not yield a satisfactory spectrum. However, the free acid of cephalothin gave a mass spectrum when the sample was flashed into the ion source using an ion source temperature of about 300 C and a separately heated direct probe into the ion source. 

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