Cellular dynamics

Interpretable high-resolution structural infomiation (e.g. preservation of dimensions, or correlation of the stmctiiral detail with a physiologically or biochemically controlled state) is therefore obtained exclusively from samples in which life has been stopped very quickly and with a sufficiently high time resolution for the cellular dynamics [19]. Modem concepts for specimen preparation therefore try to avoid traditional, chemical... 

INTERACTION OF SHALLOW CELLS CELLULAR DYNAMICS Evolution of Shallow Cells The Role of Codimension Two Bifurcations. The importance of nonlinear interactions between spatially resonant structures is... 

Hardeland, R., Poeggeler, B., Behrmann, G. 8r Fuhrberg, B. (1996). Enzymatic and non-enzymatic metabolism of methoxyindoles. In ed. Hardeland, R. Metabolism and Cellular Dynamics of Indoles. (Goettingen University of Goettingen)... 

Laboratory of Cellular Dynamics, Max Planck Institute for Biophysical Chemistry, am Fassberg 11, 37077 Gottingen, Germany... 

Nobuhiro Takahashi and Toshiaki Isobe Proteomic Biology Using LC-MS Large Scale Analysis of Cellular Dynamics and Function... 

The life of a cell is maintained by the continuous activity of a myriad of biochemical reactions that provide metabolic energy, synthesize (and degrade) structural and functional molecules such as proteins, nucleic acids and lipids, and drive cellular dynamic functions such as contraction, locomotion, and cytokinesis. These reactions are organized into networks or modules that have specific functions such as protein synthesis or production of energy by oxidative phosphorylation. Then, when a cell is in a stable state, these reaction networks must also operate stably i.e., energy is continuously generated and... 

Humoral immune responses can be divided into two types primary and secondary responses, which reflect the cellular dynamics of the immune system and the immune state of the host. A primary response is caused by the first exposure to a given immunogen and results in the appearance of predominantly IgM antibodies after a relatively long lag period, followed by a peak and a decline of antibody formation. After a lapse of time, another exposure to the immunogen produces a quite different, secondary response which is characterized by a shorter lag period, a stronger response with predominantly IgG antibodies and, after a peak has been reached, a slower decrease. 

Isabella Dalle-Donne, Andrea Scaloni, and D. Allan Butterfield Redox Proteomics From Protein Modifications to Cellular Dysfunction and Diseases Silas G. Villas-Boas, Ute Roessner, Michael A.E. Hansen, Jom Smedsgaard, and Jens Nielsen Metabolome Analysis An Introduction Mahmoud H. Hamdan Cancer Biomarkers Analytical Techniques for Discovery Chabbil Dass Fundamentals of Contemporary Mass Spectrometry Kevin M. Downard (Editor) Mass Spectrometry of Protein Interactions Nobuhiro Takahashi and Toshiaki Isobe Proteomic Biology Using LC-MS Large Scale Analysis of Cellular Dynamics and Function... 

CHIP BASED ELECTROANALYTICAL SYSTEMS FOR MONITORING CELLULAR DYNAMICS... 

Abstract. Electroanalytical methods are highly compatible with micro- and nano-machining technology and have the potential of invasive but non-destmctive cell analysis. In combination with optical probes and imaging techniques, electroanalytical methods show great potential for the development of multi-analyte detection systems to monitor in real-time cellular dynamics. 

The significance of cell-based assays as a source of information that yields a more holistic view of the cellular dynamics, i.e. the interaction of... 

Figure 1. A schematic illustration of electrochemical monitoring of cellular dynamics. An extracellularly placed electrode is used to detect cellular release and uptake of molecules.

Much has been made of the enhanced histopathology concept. In reality, this is simply a reminder to pay close attention to the histology of immune system tissues. ICH S8 recommends that a semiquantitative description of observed changes be used. This reflects the fact that lymphoid tissues demonstrate cellular dynamics indicative of potential functional changes. Once again. 

The activation of protein kinase C and subsequent induction of cell proliferation by cytotoxic chemicals has been suggested by Roghani et al. (64). The inappropriate activation of this enzyme by a chemical-receptor complex is believed to play a role in the promotion process. The activation of protein kinase C may subsequently result in the activation of a number of cytoplasmic proteins through inductional phosphorylation and set off a chain of events which includes enhanced cell proliferation in the absence of regenerative cell replication. The distinction between cytotoxicity and promotion may not always be clear. As recently discussed by Trump and Berezesky (65), chemically-induced alterations in the cellular dynamics of calcium regulation may result in a wide range of changes, many of which are similar to those caused by protein kinase C... 

Prescott, S.M. and C. Yang (2002). Many actions of cyclooxygenase-2 in cellular dynamics and in Cancer. J. Cell. Biol. 190, 279-286. 

Cohen, M.S. 1977. The cyclic AMP control system in the development of Dictyostelium discoideum. I. Cellular dynamics. J. Theor. Biol. 69 57-85. 

Ena/Mena/VASP/ family proteins (Reinhard et al. 1995) (Gertler et al. 1996) Bind to ceU adhesion proteins (Reinhard et al. 1992) (Reinhard et al. 1996) and to actin, nucleate actin filaments (Harbeck et al. 2000, Walders-Harbeck et al. 2002) Control cellular dynamics (Gertler et al. 1996, Rottner et al. 1999) (Krause et al. 2003)... 

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