Secondary responses

Restrictive cell-type-specific expression of secondary response genes. 

Signs and symptoms of sympathetic nervous system activity are invariably found in MH. Levels of catecholamines are markedly increased in MH. Whether activation of the sympathetic nervous system is a primary or a secondary response in the syndrome has not been fully elucidated. Gronert reported that stress-induced sympathetic hyperactivity can initiate a malignant hyperthermic episode in susceptible swine without a triggering agent. Stress-induced MH in humans has been inferred because susceptible families have been shown to have an increased incidence of sudden death. Gronert s reasons that activation of the sympathetic... 

IgG Main antibody in the secondary response. Opsonizes bacteria, making them easier to phagocytose. Fixes complement, which enhances bacterial killing. Neutralizes bacterial toxins and viruses. Crosses the placenta. 

Fig. 23 Saliva and serum IgA (primary and secondary) response following orally administered soluble antigen Streptococcus mutans cell wall extract (open circles, soluble antigen solid circles, liposome-encapsulated material) (phosphatidylcholine, phosphatidic acid, cholesterol). (From Ref. 277).

In a chronic study in rats (Quast et al. 1980a), some changes in the blood parameters measured were observed at various intervals during the study, but the findings did not occur consistently and were not dose-related. Therefore, the authors concluded that these findings were not direct effects of exposure to acrylonitrile, but rather were a secondary response to other effects such as weight loss, tumor formation, or inflammatory reactions. 

IgG 10-12 (80%) Monomeric structure (y-globulin) secreted from B cells during secondary response binds complement can cross placenta... 

A secondary response describes the type of reaction when an animal encounters an antigen more than once. 

Immunologically competent cells, whether they are T or B lymphocytes, have membrane receptors that are specific for an antigen. It is basically the binding of the antigen to the specific receptor on the appropriate lymphocyte which initiates the whole process, stimulating the cell to proliferate and producing a clone of identical cells, a process known as clonal selection . The nature of the secondary response is due in the main to this large number of cells now available. 

There are several reports of noteworthy extrapulmonary effects in laboratory animals with concentrations of about 0.2 ppm. These include reduced voluntary activity, chromosomal aberrations in circulating lymphocytes of hamsters, increased neonatal mortality, and greater incidence of jaw abnormalities in offspring of ozone-exposed mice. The mechanisms of these reported effects and whether th are due to direct actions of absorbed ozone, some secondary reaction product, or secondary responses to the stress of local actions in the lung are largely unknown. However, reported analogous effects in humans exposed to ozone, such as changes in visual acuity and headache (possibly related to the reduced activity in... 

Figure 17.11 Secondary response to an antigen challenge. Note the antibody concentration is a logarithm scale, so that the increase in concentration of antibody is considerably greater than would appear in the diagram.

Both the time of analysis and experimental design may affect the results. An explanation for the increase in adenylates under the conditions of our experiment is still needed. Since both ATP alone and total adenylate concentrations have increased, it does not appear that a shift in phosphorylation can account for the increases. The decrease in photosynthesis and increase in adenylates occur during the same time period and both factors return to normal after 21 hr. From previous research we know that the photosynthetic levels of ozonated pinto bean foliage decrease immediately after ozone exposure even when symptoms do not develop ( ). This does not hold true for the adenylate or respiration responses. Therefore, it appears that the ozone-initiated increase in adenylates is not correlated directly to the photosynthetic response. The increase in respiration persists when adenylate content and photosynthetic rates have returned to normal. Impaired mitochondrial function appears to be a secondary response more closely related to symptom development. 

This primary response takes some 10 days and is accompanied by the generation of memory B- and T-cells for secondary immune responses. It should be noted that immunosuppression is more effective for primary responses than for secondary responses. 

The choice of whether to make the mean the primary or the secondary response will depend on the objectives of the experiment. For example, if the objective is to have the mean on target with minimum variation then the dual response approach would suggest minimizing the variance (or... 

The application of the standard nonlinear programming techniques of constrained optimization on analyzing the mean and variance response surfaces has been investigated by Del Castillo and Montgomery [34]. These techniques are appropriate since both the primary and secondary responses are usually quadratic functions. 

Figure 3.5 Classification of the components of visually evoked potentials (VEPs). The two negative peaks I and III and the positive peak II were termed the primary response by Ciganek (1961), peaks IV-VII (negative peaks = upwards pointing peaks) being termed the secondary response. The amplitude of these peaks lies in the region of 10-30/iV. In addition to amplitudes (e.g. between peaks I and II), latencies are determined, i.e. the time in milliseconds between the stimulus and the appearance of a peak, e.g. peak IV...

The secondary response is also known as booster response. It differs from primary response and has a shorter latent period, production of antibodies is more rapid, antibodies are more abundant, antibody response is maintained at a higher level for a longer period and antibodies elicited tend to have a greater capacity to bind to the antigen. 

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