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Redox proteomics

Isabella Dalle-Donne, Andrea Scaloni, and D. Allan Butterfield Redox Proteomics From Protein... [Pg.372]

Figure 18.2 Redox proteomics and oxidatively modified proteins in the brain. Redox proteomics has the potential of detecting disease markers and identifying potential targets for drug therapy in neurodegenerative disorders. Redox proteomics involves the separation of brain proteins followed by detection, usually immunochemically, of oxidatively modified proteins, either from a two-dimensional western blot or from column eluents. Subsequent mass spectrometric analysis of tryptic digests and database searching leads to protein identification. Figure 18.2 Redox proteomics and oxidatively modified proteins in the brain. Redox proteomics has the potential of detecting disease markers and identifying potential targets for drug therapy in neurodegenerative disorders. Redox proteomics involves the separation of brain proteins followed by detection, usually immunochemically, of oxidatively modified proteins, either from a two-dimensional western blot or from column eluents. Subsequent mass spectrometric analysis of tryptic digests and database searching leads to protein identification.
Butterfield DA, Sultana R. 2007. Redox proteomics identification of oxidatively modified brain proteins in Alzheimer s disease and mild cognitive impairment Insights into the progression of this dementing disorder. J Alzheimers Dis 12 61-72. [Pg.444]

Butterfield DA, Abdul HM, Newman S, Reed T. 2006a. Redox proteomics in some age-related neurodegenerative disorders or models thereof. NeuroRx 3 344—357. [Pg.444]

Butterfield DA, Perluigi M, Sultana R. 2006b. Oxidative stress in Alzheimer s disease brain New insights from redox proteomics. Eur J Pharmacol 545 39-50. [Pg.444]

Calabrese V. 2007. Highlight commentary on Redox proteomics analysis of oxidatively 3 modified proteins in G93A-SOD1 transgenic mice-A model of 4 familial amyotrophic lateral sclerosis. Free Radical Biol Med 43 160-162. [Pg.444]

Sultana R, Perluigi M, Butterfield DA. 2006b. Protein oxidation and lipid peroxidation in brain of subjects with Alzheimer s disease Insights into mechanism of neurodegeneration from redox proteomics. Antioxid Redox Signal 8 2021-2037. [Pg.451]

F., Cai, J., Pierce, W. M., Klein, J. B., Merchant, M., Markesbery, W. R., Butterfield, D. A. Redox proteomics identification of oxidized proteins in Alzheimer s disease hippocampus and cerebellum An approach to understand pathological and biochemical alterations in AD. Neurobiol. Aging 2006, 27 1564-1576. [Pg.254]

Redox regulation of surface protein thiols identification of integrin alpha-4 as a molecular target by using redox proteomics. Proc. Natl. Acad. Sci. USA 100, 14737-14741. [Pg.256]

Butterfield DA, Kanski J (2002) Methionine residue 35 is critical for the oxidative stress and neurotoxic properties of Alzheimer s amyloid beta-peptide 1-42. Peptides 23 1299-1309 Butterfield DA, Lauderback CM (2002) Lipid peroxidation and protein oxidation in Alzheimer s disease brain potential causes and consequences involving amyloid beta-peptide-associated free radical oxidative stress. Free Radic Biol Med 32 1050-1060 Butterfield DA, Poon HF, St Clair D, Keller JN, Pierce WM, Klein JB, Markesbery WR (2006a) Redox proteomics identification of oxidatively modified hippocampal proteins in mUd cognitive impairment Insights into the development of Alzheimer s disease. Neurobiol Dis 22(2) 223-232... [Pg.599]

Smith MA, Richey Harris PL, Sayre LM, Beckman JS, Perry G (1997) Widespread peroxynitrite-mediated damage in Alzheimer s disease. J Neurosci 17 2653-2657 Stadtman ER, Levine RL (2003) Free radical-mediated oxidation of free amino acids and amino acid residues in proteins. Amino Acids 25 207-218 Stuehr DJ (1999) Mammalian nitric oxide synthases. Biochim Biophys Acta 1411 217-230 Sultana R, Boyd-Kimball D, Poon HF, Cai J, Pierce WM, Klein JB, Markesbery WR, Zhou XZ, Lu KP, Butterfield DA (2006c) Oxidative modification and down-regulation of Pinl in Alzheimer s disease hippocampus A redox proteomics analysis. Neurobiol Aging 27(7) 918-925... [Pg.604]

Gerbil cortex 2-DE MALDI-TOF LC-MS/MS Western blot Redox proteome (Boyd-Kimball et al. 2005)... [Pg.83]

Sultana R, Poon HF, Cai J, Pierce WM, Merchant M, Klein JB, Markesbery WR, Butterfield DA (2006) Idendficadon of nidated proteins in Alzheimer s disease brain using a redox proteomics approach. Neurobiol Dis 22(l) 76-87. [Pg.740]

Isabella Dalle-Donne, Andrea Scaloni, and D. Allan Butterfield Redox Proteomics From Protein Modifications to Cellular Dysfunction and Diseases Silas G. Villas-Boas, Ute Roessner, Michael A.E. Hansen, Jom Smedsgaard, and Jens Nielsen Metabolome Analysis An Introduction Mahmoud H. Hamdan Cancer Biomarkers Analytical Techniques for Discovery Chabbil Dass Fundamentals of Contemporary Mass Spectrometry Kevin M. Downard (Editor) Mass Spectrometry of Protein Interactions Nobuhiro Takahashi and Toshiaki Isobe Proteomic Biology Using LC-MS Large Scale Analysis of Cellular Dynamics and Function... [Pg.349]

Fratelli, M., Demol, H., Puype, M., Casagrande, S., Eberini, I., Salmona, M., Bonetto, V., Mengozzi, M., Duffieux, F., Miclet, E., Bachi, A., Vandekerckhove, J., Gianazza, E., and Ghezzi, P., 2002, Identification by redox proteomics of glntathionylated proteins in oxidatively stressed human T lymphocytes. Proc. Natl. Acad. Sci. U. S. A 99 3505-3510. [Pg.90]

Igor A. Kaltashov and Stephen J. Bylcs Mass Spectrometry in Biophysics Confirmation and Dynamics of Biomolecules Isabella Dallc-Donnc, Andrea Scaloni, and D. Allan Butterfield Redox Proteomics From Protein Modifications to Cellular Dysfunction and Diseases... [Pg.355]

Redox Proteomics, Lipid Peroxidation, and Neurodegenerative Disorders.330... [Pg.329]

Aluise, C. D., R. A. Robinson, J. Cai et al. Redox proteomics analysis of brains from subjects with amnestic mild cognitive impairment compared to brains from subjects with preclinical Alzheimer s disease Insights into memory loss in MCI. J Alzheimers Dis 23(2), 2011 257-69. [Pg.351]

Di Domenico, F., R. Sultana, A. Ferree et al. Redox proteomics analyses of the influence of co-expression of wild-type or mutated LRRK2 and Tan on C. elegans protein expression and oxidative modification Relevance to Parkinson disease. AiUiojddRedox Sign 17(11), 2012 1490-506. [Pg.354]

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See also in sourсe #XX -- [ Pg.30 ]



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