Clinical applications, capillary electrophoresis

See also Capillary Electrophoresis Clinical Applications. Forensic Sciences DNA Profiling. Lab-on-a-Chip Technologies. Mass Spectrometry Polymerase Chain Reaction Products. Nucleic Acids Chromatographic and Electrophoretic Methods. 

See also Capillary Electrophoresis Clinical Applications. Electrophoresis Principles Clinical Applications. 

See also Capillary Electrochromatography. Capillary Electrophoresis Pharmaceutical Applications Low-Molecular-Weight Ions Food Chemistry Applications Clinical Applications. Extraction Solid-Phase Extraction Solid-Phase Microextraction. Gas Chromatography Mass Spectrometry. Liquid Chromatography Overview Liquid Chromatography-Mass Spectrometry. 

J.R. Petersen and A.A. Mohammad, (Eds.), Clinical and Forensic Applications of Capillary Electrophoresis, Humana Press, Inc., New Jersey, USA, 2001. 

Guzman, N. A. (2004). Immunoaffinity capillary electrophoresis applications of clinical and pharmaceutical relevance. Anal. Bioanal. Chem. 378(1), 37-39. 

Miniaturised devices electrochemical capillary electrophoresis microchips for clinical application... 

The aim of this chapter is to show through the subsequent sections the present trends in capillary electrophoresis microchips paying special attention to the manufacturing and designs employed in those combined to electrochemical (EC) detection. Conductimetric and amperometric detection are considered. Clinical application of these devices is further revised. 

Automation in the Clinical Laboratory Biosensor Design and Fabrication Capillary Electrophoresis in Clinical Chemistry DNA Arrays Preparation and Application Drugs of Abuse, Analysis of Molecular Biological Analyses and Molecular Pathology in Clinical Chemistry Nucleic Acid Analysis in Clinical Chemistry Phosphorescence, Fluorescence, and Chemiluminescence in Clinical Chemistry Product Development for the Clinical Laboratory... 

One of the most important applications of capillary electrophoresis has been the separation of DNA for clinical purposes. Thus, it is logical that a major application of microchip technology is DNA separations. One of the first examples of a DNA separation on a microdevice with a clinical application was accomplished by Effenhauser et al. [61], This research demonstrated separation of fluorescently labeled oligonucleotides, ranging in size from 10 to 25 base pairs, in only 45 s in a 3.8-cm channel length. Because the DNA fragments were so... 

Thormann W, Molteni S, Caslavska J, Schmutz A (1994) Clinical and forensic applications of capillary electrophoresis. Electrophoresis 153-12. 

Hempe JM, Vargas A, Graver RD. Clinical analysis of structural hemoglobin variants and Hb Ale by capillary isoelectric focusing. In Petersen JR, Mohammad AA, eds. Clinical and forensic applications of capillary electrophoresis. Totowa, NJ Humana Press, 2001 145-63. 

Oda RP, Bush VJ, Landers JP. Clinical applications of capillary electrophoresis. In Landers JP, ed. Handbook of capillary electrophoresis, 2" Edition. Boca Raton CRC Press, 1997 639-73. 

From the perspective of the clinical laboratory, miniaturization has been a long-term trend in clinical diagnostics instrumentation. For example, capillary electrophoresis instruments (see Chapter 5) and mass spectrometers have been implemented on microchips of silicon, glass, or plastic. In actuality, however, these devices are not manufactured on a nanometer scale but rather on a micrometer scale. Consequently, this chapter will be concerned with microminiaturized devices whose key components (1) are approximately 100 micrometers in size, (2) are employed in analytical measurement, and (3) require special forms of fabrication designed for microdevices. Although this chapter does not attempt to discuss submicron or molecular structures at the nanometer scale, it should be noted that applications discussed later in it require only nanoliter (nL) quantities of a sample or deal with individual cells that may have cell volume in the picoHter (pL) to nL range. 

Phillips, T. M. Kalish, H., Eds. Clinical Applications of Capillary Electrophoresis, Humana Press Totowa (NJ), 2013. 

Much has happened since the first edition appeared in 1982 and the second edition appeared in 1987. Ion chromatography has undergone impressive technical developments and has attracted an ever-growing number of users. The instrumentation has improved and the wealth of information available to the user has increased dramatically. Research papers and posters on new methodology and on applications in the power and semiconductor industries, pharmaceutical, clinical and biochemical applications and virtually every area continue to appear. An increasing number of papers on ion analysis by capillary electrophoresis is also included. Ion chromatography is now truly international in its scope and flavor. 

---