Hemoglobins structure

R. E. Dickerson and I. Geis, Hemoglobin Structure, Tunction, Evolution andPathology, Benjamin/Cummings, Menlo Park, Calif., 1983. 

Dickerson, R. E., and Geis, I., 1983. Hemoglobin Structure, Function, Evolution and Pathology. Menlo Park, CA Benjamin/Cnmming.s. 

Schroeder, W. A. "Hemoglobin Structure and Function. The Proteins", H. Neurath and R. Hill, Eds., Academic Press,... 

The term quaternary structure is employed to describe the overall shape of groups of chains of proteins, or other molecular arrangements. For instance, hemoglobin is composed of four distinct but different myoglobin units, each with its own tertiary structure that comes together giving the hemoglobin structure. Silk, spiderwebs, and wool, already described briefly, possess their special properties because of the quaternary structure of their particular structural proteins. 

Dickerson. R. E. Ceis, I. The Struvttire and Anion of Proteins Harper Row New York. 1969 p 59. Hemoglobin Structure. Function. Involution anti Ptuhnlopy. Benjnmin/Cumtnings Menlo Park. CA, 1983. Baldwin, J. Chotlna. C. J. Mol Biol. 1979. 129. 175... 

In addition there has been a recent review of manganese porphyrin chemistry (19) as well as of the aqueous and chloro complexes of the porphyrin species (20). These discussions are complemented by a discussion of the electrochemistry of manganese porphyrin compounds (21). Related studies include the phthalocyanine complexes (22), the manganese (III)-hemoglobin structure (23), and the characterization of macrocyclic complexes of manganese (24, 25). Other relevant chemistry involves the Schiff-base complexes of Mn(III) (26, 27, 28). 

A representation of the hemoglobin structure. There are two slightly different types of protein chains (a and /3). Each hemoglobin has two a chains and two p chains, each with a heme complex near the center. Thus each hemoglobin molecule can complex with four 02 molecules. 

The scheme of Fig. 8 summarizes eight hemoglobin structural loci, their polypeptide chain products, and the various hemoglobin types which are found in the human at different stages of development. 

Necheles, T. F. Allen, D. M. Finkel, H. E., "Clinical Disorders of Hemoglobin Structure and Synthesis", Appleton-Century-Crofts, N.Y., 1969. 

M. F. Perutz Hemoglobin structure and respiratory transport. Scientific American 239(6), 92 (1978). 

SECTION 28.3 Inherited Disorders of Hemoglobin Structure and Synthesis... 

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