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Protein cancer

Buisson R, Dion C, Arme M et al (2010) Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recomhination. Nat Struct Mol Biol 17 1247-1254... [Pg.136]

Wang, X. T., Nagaba, Y., Cross, H. S., Wrba, F., Zhang, L. and Guggino, S. E., 2000, The mRNA of L-type calcium channel elevated in colon cancer protein distribution in normal and cancerous colon. Am J Pathol 157, 1549-62. [Pg.428]

Gill AL, Verdonk M, Boyle RG, Taylor R (2007) A comparison of physicochemical property profiles of marketed oral dmgs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem 7 1408-1422... [Pg.46]

Septicin antibacterial implant for the treatment of chronic bone infections have been developed [21-24]. The multidisciplinary concept of polymeric implants has expanded to include research on the chemistry and characterization of polymers, experimental and theoretical polymer degradation and drug release, toxicology and metabolism, and research in specific fields of applications such as cancer, proteins and hormones delivery, infectious diseases, and brain disorders. This chapter concentrates on the chemistry and characterization of polyanhydrides with a brief description on recent applications of polyanhydrides. [Pg.99]

Silicon nanowires incorporated into arrays provide label-free, multiplexed electrical detection of cancer protein biomarkers such as prostate-specific antigen at femtomolar concentrations with high sensitivity in clinically relevant serum samples [7]. Real-time assays of the binding, activity, and small-molecule inhibition of telomerase could be performed with this technique using unamplified extracts from as few as 10 tumor cells. This opens up substantial possibilities for diagnosis and treatment of cancer. [Pg.246]

Snyder EL, Meade BR, Dowdy SF. Anti-cancer protein transduction strategies reconstitution of p27 tumor suppressor function. J Control Release 2003 91 45-51. [Pg.320]

In the human tumor, prostate adenocarcinoma, the PRC 17 protein (polycomb group repressive complex) is encoded from the 17ql2 amplicon [524]. The PRC (prostate cancer) protein contains a GTPase-activating protein GAP domain related to the yeast ceU cycle regulators Bub2 and the RabA tp-specific GTPase activator... [Pg.148]

As is apparent in Chapter 8, phosphates are the most polar molecular species available in biology for controlling hydrophobic association/ dissociation, that is, for controlling processes that occur by inverse temperature transition. It follows, therefore, that kinases for phosphorylation and phosphatases for dephosphorylation would be fundamental to key cellular trans-ductional and transformational processes. Often in cancerous and other diseased states, the activities of these enzymes are abnormal. Importantly for our interests, their sites of interaction can be very selective. Changes in protein kinase C activities have been reported to be abnormal in colon, breast, and skin cancers. Protein tyrosine kinase, which selectively phos-phorylates the internal tyrosine (Tyr,Y) residue in the sequence GIYWHHY, is overexpressed in colon and breast cancer. " Furthermore, cyclic AMP-dependent protein kinase activities have been associated with the onset of... [Pg.532]

B.V. Chikkaveeraiah, A.A. Bhirde, N Y. Morgan, H.S. Eden, X. Chen, Electrochemical immunosensors for detection of cancer protein biomarkers, ACS Nano 6 (2012) 6546-6561. [Pg.140]

Many human diseases are caused when certain proteins are either over- or underexpressed. Eor example, breast cancer can be induced by overexpressing certain cellular oncogenes within mammary tissue. To study the disease, researchers produce a line of transgenic mice that synthesize an abnormal amount of the same protein. This leads to symptoms of the disease in mice that are similar to what is found in humans. A protein can be overexpressed by inserting a DNA constmct with a strong promotor. Conversely, underexpression of a protein can be achieved by inserting a DNA constmct that makes antisense RNA. This latter blocks protein synthesis because the antisense RNA binds and inactivates the sense mRNA that codes for the protein. Once a line of mice is developed, treatments are studied in mice before these therapies are appHed to humans. [Pg.242]

In experimental animals and in vitro, DHBs show a variety of biological effects including binding of metaboHtes to various proteins. Clastogenic effects have been observed in vitro and in some in vivo studies with the three compounds. No reproductive effects have been shown by conventional studies with either hydroquinone, catechol, or resorcinol (122). Hydroquinone has been shown to induce nephrotoxicity and kidney tumors at very high doses in some strains of rat (123) catechol induces glandular stomach tumors at very high dose (124). Repeated dermal appHcation of resorcinol did not induce cancer formation (125). [Pg.494]

Chemiluminescence has been studied extensively (2) for several reasons (/) chemiexcitation relates to fundamental molecular interactions and transformations and its study provides access to basic elements of reaction mechanisms and molecular properties (2) efficient chemiluminescence can provide an emergency or portable light source (J) chemiluminescence provides means to detect and measure trace elements and pollutants for environmental control, or clinically important substances (eg, metaboHtes, specific proteins, cancer markers, hormones, DNA) and (4) classification of the hioluminescent relationship between different organisms defines their biological relationship and pattern of evolution. [Pg.262]

ImmunO lSS iy. Chemiluminescence compounds (eg, acridinium esters and sulfonamides, isoluminol), luciferases (eg, firefly, marine bacterial, Benilla and Varela luciferase), photoproteins (eg, aequorin, Benilld), and components of bioluminescence reactions have been tested as replacements for radioactive labels in both competitive and sandwich-type immunoassays. Acridinium ester labels are used extensively in routine clinical immunoassay analysis designed to detect a wide range of hormones, cancer markers, specific antibodies, specific proteins, and therapeutic dmgs. An acridinium ester label produces a flash of light when it reacts with an alkaline solution of hydrogen peroxide. The detection limit for the label is 0.5 amol. [Pg.275]

The American Dietetic Association, the American Heart Association, and the National Heart, Lung and Blood Institute recommend 142—198 g (5—7 02) of lean, trimmed meat daily. It was also pointed out that trimmed meat, especially red meat, provides large amounts of essential nutrients such as iron, 2inc, vitamin balanced protein. The idea that the risk of CHD and cancer can be greatiy reduced by avoiding a meat-centered diet have prompted... [Pg.31]


See other pages where Protein cancer is mentioned: [Pg.1015]    [Pg.152]    [Pg.737]    [Pg.1015]    [Pg.410]    [Pg.105]    [Pg.485]    [Pg.131]    [Pg.995]    [Pg.974]    [Pg.152]    [Pg.2754]    [Pg.17]    [Pg.7724]    [Pg.108]    [Pg.453]    [Pg.1015]    [Pg.152]    [Pg.737]    [Pg.1015]    [Pg.410]    [Pg.105]    [Pg.485]    [Pg.131]    [Pg.995]    [Pg.974]    [Pg.152]    [Pg.2754]    [Pg.17]    [Pg.7724]    [Pg.108]    [Pg.453]    [Pg.184]    [Pg.221]    [Pg.241]    [Pg.41]    [Pg.302]    [Pg.430]    [Pg.207]    [Pg.497]    [Pg.445]    [Pg.40]    [Pg.164]    [Pg.49]    [Pg.308]    [Pg.313]    [Pg.106]    [Pg.117]    [Pg.119]    [Pg.57]    [Pg.77]    [Pg.104]   
See also in sourсe #XX -- [ Pg.774 , Pg.775 , Pg.776 ]

See also in sourсe #XX -- [ Pg.254 ]




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