Polymeric implants

Polymeric implants and pellets require minor surgery for both their insertion and removal. [Pg.119]

One major finding of this study was that the polymeric implants remained intact throughout the 1-year course of the experiments, in complete agreement with the predictions based on in vitro experiments. [Pg.209]

Title Degradable Polymeric Implantable Medical Devices with a Continuous Phase and Discrete Phase... [Pg.613]

Polymeric implants - [FOAMED PLASTICS] (Vol 11) - [ACRYLONITRTLEPOLYMERS - SURVEY AND SAN (STYRENE-ACRYLONITRILECO-POLYMERS)] (Vol 1) -for contraception [CONTRACEPTIVES] (Vol 7)... [Pg.788]

Non-degradable polymeric implants are divided into two main types (see also section 3.2) ... [Pg.77]

Poly(ethylene-co-vinyl acetate) (EVA copolymer) is also widely used as a non-degradable polymeric implant. These copolymers have the advantages of ... [Pg.78]

The penetration of a solvent, usually water, into a polymeric implant initiates dmg release via a diffusion process. Diffusion of dmg molecules through non-porous polymer membranes depends on the size of the dmg molecules and the spaces available between the polymeric chains. Even through the space between the polymer chains may be smaller than the size of the dmg molecules, dmg can still diffuse through the polymer chains due to the continuous movement of polymer chains by Brownian motion. [Pg.78]

Figure 4.3 The steady-state concentration profile of a drug in a reservoir-type polymeric implant Cr=concentration of drug in the reservoir, concentration of drug at the site of implantation...

Figure 4.4 M t Zero-order controlled release profile of a reservoir-type nondegradable polymeric implant (porous or compact membrane)...

Figure 4.10 Hybrid-type polymeric implants (a) Syncro-Mate-C matrix containing microreservoirs of drug, (b) Implanon membrane coating a drug containing matrix...

Reservoir/matrix hybrid-type non-degradable polymeric implants are also available. Such systems are designed in an attempt to improve the M t1/2" release kinetics of a matrix system, so that release approximates the zero-order release rate of a reservoir device. Examples of these types of systems include ... [Pg.87]

Reservoir/matrix hybrid-type polymeric implants... [Pg.87]

Such limitations prompted scientists to develop biodegradable polymeric implants. Degradation can take place via ... [Pg.88]

The drag release for biodegradable polymeric implants is governed not by diffusion through a membrane, but by degradation of the polymer membrane or matrix. [Pg.89]

A company is trying to develop a reservoir-type polymeric implant for the controlled release of estradiol for 3 months. Which techniques would you recommend to the company to increase the drag release rate ... [Pg.103]

The release rate of a dmg from conventional non-degradable matrix-type polymeric implant usually decreases over time. Describe a technique that can be used to overcome this problem. [Pg.103]

What is the main reason for developing a reservoir/matrix hybrid-type polymeric implant ... [Pg.103]

Which polymer is most extensively used as non-degradable nonporous membrane to develop reservoir-type polymeric implants ... [Pg.103]

As for icv infusion, this is a highly invasive approach. The distribution of drug into the brain following the intracerebral implantation of a polymeric implant is also limited by diffusion, with a maximal penetration of drag into brain parenchyma of < 1 mm. [Pg.328]

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