Polycomb group

Surprisingly, C. elegans appears to have lost a considerable number of chromatin proteins from the Polycomb group of proteins, observed in Drosophila and in mammals, although other transcription factor genes... 

Klymenko T, Papp B, Fischle W, Kocher T, Schelder M, Fritsch C, Wild B, Wilm M, Muller J (2006) A Polycomb group protein complex with sequence-specific DNA-binding and selective methyl-lysinebinding activities. Genes Dev 20 1110-1122... 

Varambally S, Dhanasekaran SM, Zhou M, Barrette TR, Kumar-Sinha C, Sanda MG, Ghosh D, Pienta KJ, Sewalt RG, Otte AP, Rubin MA, Chinnaiyan AM (2002) The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature 419 624-629 Wade PA, Pruss D, Wolffe AP (1997) Trends Biochem Sci 22 128-132... 

Apart from this HDACs are also associated with a number of other epigenetic repression mechanisms including histone methylation, polycomb group of proteins and DNA methylation (discussed later). The class II HDACs have been found to be involved in muscle development, particularly HDAC 5 and 9 knockouts or mutants show evidence of cardiac hypertrophy in a age or stress dependent manner (Zhang et al, 2002 Chang et al, 2004). 

Vire, E. et al. (2006) The Polycomb group protein EZH2 directly controls DNA methylation. Nature, 439, 871-874. 

Regulation of homeotic gene expression by the trithorax and polycomb groups of proteins... 

Gould, A. 1997. Functions of mammalian Polycomb-group and trithorax-group related genes. Curr. Opin. Genet. Dev. 7, 488-494. 

Flox expression patterns are sometimes maintained through positive autoregulatory loops, and through modulation of chromatin by proteins encoded by Polycomb-group and Trithorax-group genes. 

Jones, R. S., and Gelbart, W. M. (1993). The Drosophila Polycomb-group gene Enhancer of zeste contains a region with sequence similarity to trithorax. Mol. Cell. Biol. 13(10), 6357-6366. 

In the human tumor, prostate adenocarcinoma, the PRC 17 protein (polycomb group repressive complex) is encoded from the 17ql2 amplicon [524]. The PRC (prostate cancer) protein contains a GTPase-activating protein GAP domain related to the yeast ceU cycle regulators Bub2 and the RabA tp-specific GTPase activator... 

Ryu S, McDonnell K, Choi H, Gao D, Hahn M, Joshi N, Park SM, Catena R, Do Y, Brazin J, Vahdat LT, Silver RB, 2026. Ryu S, McDonnell K, Choi H, Gao D, Hahn M, Joshi N, Park SM, Catena R, Do Y, Brazin J, Vahdat LT, Silver RB, Mittal V. Suppression of miRNA-708 by polycomb group promotes metastases by calcium-induced cell migration. Cancer Cell. 2013 23 63-76. 

Mittal V. Suppression of mRNA-708 by polycomb group promoters metastases by calcium-induced cell migration. Cancer Cell. 2013 23 63-76. 

Jones CA, Ng J, Peterson AJ, Morgan K, Simon J, Jones RS. The Drosophila esc and E (z) proteins are direct partners in polycomb group-mediated repression. Mol Cell Biol. 1996 18 2825-34. 

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