Stomach Tumors

In experimental animals and in vitro, DHBs show a variety of biological effects including binding of metaboHtes to various proteins. Clastogenic effects have been observed in vitro and in some in vivo studies with the three compounds. No reproductive effects have been shown by conventional studies with either hydroquinone, catechol, or resorcinol (122). Hydroquinone has been shown to induce nephrotoxicity and kidney tumors at very high doses in some strains of rat (123) catechol induces glandular stomach tumors at very high dose (124). Repeated dermal appHcation of resorcinol did not induce cancer formation (125). 

FAHEY J W, HARISTOY X, DOLAN P M, KENSLER T W, SCHOLTUS I, STEPHENSON K K, TALALAY p and LOZNIEWSKI a (2002) Sulforaphane inhibits extracellular, intracellular and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors , Proc Natl Acad Sci USA, 99 7610-15. 

For example, 7,12-dimethylbenz[a]anthracene is a particularly potent carcinogen for the mammary gland of young female Sprague-Dawley rats after oral or intravenous administration (25,26), dietary benzo[a]pyrene leads to leukemia, lung adenoma and stomach tumors in mice (27), and either of these hydrocarbons can induce hepatomas in male mice when injected on the first day of life (28). Nevertheless, the mouse skin system has proved to be particularly valuable because of the rapidity of tumor induction, the ease of detection of tumors and because the multi-stage nature of the carcinogenic process was experimentally established in this system. 

PAH bind to the Ah receptor, this effect is not the only effect that determines the carcinogenic potency of PAH. DNA binding and induction of mutations are other significant effects in the carcinogenesis of PAH, and there is no indication that different PAH are activated via the same metabolic route, binds DNA in the same positions, and induce the same types of mutations in the same organs or tissues. In fact, the study by Culp et al. (1998) showed that a coal-tar mixture of PAH also produced tumors in other tissues and organs than those affected by benzo[a]pyrene alone, and that the additional PAH in the mixture did not significantly contribute to the incidence of stomach tumors observed after benz[a]pyrene alone. 

Friedman, M., McQuistan, T., Hendricks, J. D., Pereira, C., Bailey, G. S. (2007). Protective effect of dietary tomatine against dibenzo[a,l]pyrene (DBP)-induced liver and stomach tumors in rainbow trout. Mol. Nutr. Food Res., 51,1485-1491. 

Kim, D. J., B. W. Ahn, B. S. Han, and H. Tsuda. 1997. Potential preventive effects of Chelidonium majis L. (Papaveraceae) herb extract on glandular stomach tumor development in rats treated with V-methyl-V -nitro-V nitrosoguanidine (MNNG) and hypertonic sodium chloride. Cancer Lett. 112 203-208. 

An oral slope factor of 7.3 mg kg day has been calculated for benzo[a]pyrene based on the incidence of stomach tumors in mice treated with ben-zo[fl]pyrene. 

Rigdon RH, Neal J. 1969. Relationship of leukemia to lung and stomach tumors in mice fed benzo[a]pyrene. Proc Soc Exp Biol Med 130 146-148. 

In an initiation-promotion skin bioassay conducted at New York University Medical Center (12), 69.0 mg of DBCP was applied to the skin of female mice, followedTy repeated application of phorbol myri state acetate three times weekly for 499 days. The most significant finding from this study was the occurrence of lung papillomas and squamous cell carcinomas of the forestomach indicating that the occurrence of stomach tumors in the oral studies may be systemic and not merely related to an irritant effect at the site of application. 

The rat stomach tumors are probably due to the epoxide function. The mouse ovary/Iiver tumor may be related to the ge-... 

Cooking meat produces mixtures of heterocyclic amines, and exposure to heterocyclic amines may be involved in the development of tumors, including breast, colon, and stomach tumors in humans.40... 

Human stomach tumor 8.41 pmol/g tissue Schmid, Wold, Krebsbach, et al. (2002)... 

Gastric tumors in rats can be promoted by a number of naturally occurring plant products. A number of phenols (Farnsworth al., 1976), hydrazones (Braun et., 1981) and catechols (Hirono, T572 Hirono, 1981) have been shown to promote stomach tumors in... 

Biochanin A Inhibition of stomach tumor growth Human cell lines... 

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