Lymphoma, cancer

Examples of inhibitors of chromatin function derived from flowering plants (Fig. 80) are etoposide (lignan) and alkaloids camptothecin, Vinca alkaloids, and 7 epitaxol. The rhizome of Podophyllum peltatum L. (May apple, Berberidaceae) has been used to remove warts and to relieve the bowels from costiveness since very early times. It contains podophyllo-toxin, a cytotoxic lignan from which etoposide (Vepesid ), which is used to treat lung cancer, lymphomas, and leukemias on account of its ability to inhibit the activity of... 

Suggested Alternatives for Differential Diagnosis Blastomycosis, coccidioidomycosis, aspergillosis, pneumonia, respiratory distress syndrome, mediastinal cysts, mycoplasma infections, Pancoast syndrome, sarcoidosis, tuberculosis, lung abscess, lung cancer, lymphoma. 

Cancer Antibodies Metastatic cancer, lymphoma Herceptin, Avastin, Rituxan, Erbitux, Procrit, Gleevec, Sutent... 

Etoposide is most useful against testicular and ovarian germ cell cancers, lymphomas, small cell lung cancers, and acute myelogenous and lymphoblastic leukemia. Toxicities include mild nausea, alopecia, allergic reaction, phlebitis at the injection site, and bone marrow toxicity. 

Acute myelogenous leukemia Breast, ovarian cancer, lymphomas... 

Etoposide is used to combat several types of tumors, including testicular and small-cell lung cancers, lymphoma, leukemia, and Kaposi s sarcoma. 

Bladder Cancer Brain Cancer Breast Cancer Cervical Cancer Colon Cancer Head/Neck Cancer Kidney Cancer Leukemia Liver Cancer Lung Cancer Lymphoma Multiple Myeloma Neuroblastoma Ovarian Cancer Pancreatic Cancer Prostate Cancer Sarcoma Skin Cancer Solid Tumors Stomach Cancer Cancer-Related Conditions Other Cancers Unspecified Cancers... 

Many advances in treatment and understanding of the molecular biology of cancer have been made since the mid-1970s. Some previously fatal cancers are now largely curable (for example cervical cancer, testicular cancer, lymphoma and leukaemia) and there have also been improvements in treatment of ongoing disease and in palliative care. 

Podophyllotoxin is extracted from the mandrake plant. Podophyllum peltatum. A derivative of this chemical, etoposide, is used in small cell lung cancer, lymphoma and testicular cancer. The mode of action of etoposide is not completely known, but it may be due to an inhibitory effect on topoisomerase similar to that of doxombicin (see above). 

Testicular cancer lymphomas squamous cell carcinoma of head, neck, skin and genitalia. 

Delbeke D (1999) Oncological applications of FDG PET imaging brain tumors, colorectal cancer, lymphoma and melanoma. J Nucl Med 40 591-603... 

MTBE has been found to cause kidney cancers, leukemias, liver cancers, lymphomas, and testicular cancers in animals. Many laboratory experiments have been conducted on shortterm acute exposure, but very few chronic studies have been done on animals. Animals tested include rats, rabbits, and mice. Most of these experiments identified the central nervous system as the most sensitive target organ. The following toxic effects occurred in these animals at various doses and times. 

The focal appearance can also consist of an infiltration that results in pronounced eccentric or circumferential bowel wall thickening. As a consequence, the intestinal lumen may be narrowed. However, unlike colon cancer, lymphoma can also show a dilated caliber in the form of an aneurysmal dilatation due to infiltration and destruction of the myenteric plexus (Montgomery and Chew... 

Echopoor Breast cancer Lung cancer Lymphoma Pancreas... 

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