Cancer cell proliferation

Levy, J., E. Bosin, B. Feldman et al. 1995. Lycopene is a more potent inhibitor of human cancer cell proliferation than either alpha-carotene or beta-carotene. Nutr Cancer 24(3) 257-266. 

In the laboratory, apples have been found to have very strong antioxidant activity, inhibit cancer cell proliferation, decrease lipid oxidation, and lower cholesterol (Boyer... 

Grube BJ, Eng ET, Yeh CK, Kwon A and Shiuan C. 2001. White button mushroom phytochemicals inhibit aromatase activity and breast cancer cell proliferation. J Nutr 13 3288-3293. 

Kavanagh KT, Hafer LJ, Kim DW, and others. 2001. Green tea extracts decrease carcinogen-induced mammary tumor burden in rats and rate of breast cancer cell proliferation in culture. J Cell Biochem 82(3) 387—398. 

Knowledge of the intracellular thermodynamics and kinetics of metal metabolism may become useful in the design of compounds that alter intracellular metal ion availability. This in turn may be useful in controlling such biological phenomena as cancer cell proliferation, disorders of metal metabolism, and metal-induced neurotoxicity. 

It is somewhat surprising that only a few investigations are available on the in-vitro studies of the suppression of cancer cell proliferation by the passage of electric current almost all publications deal with the in-vivo work on solid tumors. 

Kikuchi, Y., Sasa, H., Kita, T., Hirata, J., Tode, T., and Nagata, I. (1991). Inhibition of human ovarian cancer cell proliferation in vitro by ginsenoside Rh2 and adjuvant effects of cisplatin in vivo. Anticancer Drugs 2, 6S-67. 

Herceptin attaches to the HER2/neu receptor and activates the complement system (a series of serum and cell-associated proteins involved in immune response) to destroy those cells expressing such receptors. Through this action, Herceptin disrupts the signaling pathway for breast cancer cell proliferation (refer to diagram below). 

Damm K, Hemmann U, Garin Chesa P et al. A highly selective telomerase inhibitor limiting human cancer cell proliferation. EMBO J. 2001 20 6958-6968. 

FDA) for use in humans to treat malaria because this drug is considered a safe drug with few side effects.These features prompted various scientists around the world to evaluate the potential of artemisinin (1) and derivatives to control cancer cells proliferation. This chapter reviews the recent advances on analytical methods for extraction and quantification of artemisinin (1) from A. annua. Examples of artemisinin-derivatives with antiproliferative activities are listed, describing the structure-activity relationships of 96 compounds. This knowledge is essential for future development and use of artemisinin derivatives in cancer therapy. The mechanism of action of artemisinin and derivatives on cancer cells have been well reviewed in literature and therefore is not discussed in this chapter. 

Umehara K, Nemoto K, Ohkubo T, Miyase T, Degawa M, Noguchi H (2004) Isolation of a New 15-Membered Macrocyclic Glycolipid Lactone, Cuscutic Resinoside A from the Seeds of Cuscuta chinensis A Stimulator of Breast Cancer Cell Proliferation. Planta Med 70 299... 

Yamane, K., Tateishi, K., Klose, R.J., Fang, J., Fabrizio, L.A., Erdjument-Bromage, H., Taylor-Papadimitriou, J., Tempst, P. and Zhang, Y. (2007) PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation. Molecular Cdl, 25, 801-812. 

Inhibition of cancer cell proliferation by O-ether derivatives of HA. . 628... 

Rask L, Balslev E, Jorgensen S et al (2011) High expression of miR-21 in tumor stroma correlates with increased cancer cell proliferation in human breast cancer. APMIS 119 663-673... 

Yet what we really need is a well-controlled study of human cancer patients who supplement their diet with flaxseed. Just such a study is under way at the University of Toronto. One hundred women with newly diagnosed breast cancer have been enrolled, and each day half of them eat a muffin containing twenty-five grams of flaxseed. Results so far show a decrease in breast-cancer cell proliferation. But do we really have to wait for the final outcome of such a study to increase our flax Intake There s no reason we should. We ve seen enough evidence... 

In contrast, enterodiol and enterolactone were believed to be partly responsible for the growth inhibition of three human prostate cancer cell lines (Lin et al., 2001). Morton et al. (1997) reported that higher enterolactone levels in prostatic fluid were associated with populations with a low risk of prostate cancer. In a small clinical study, prostate cancer cell proliferation decreased and apoptosis increased in men fed 30 g of flaxseed per day (Demark-Wahnefried et al., 2001). A significant factor which may have influenced this study was that the subjects were on a low-fat diet. A subsequent study by the authors further supported the role of flaxseed in combination with a low-fat diet as a means to control prostate growth (Demark-Wahnefried et al., 2004). In this study, prostate-specific antigen level and cell proliferation both decreased from baseline after only 6 months on the dietary regime. 

ZR-75-1 and MCF-7 human breast cancer cell proliferation in the absence of estrogens. 

Onuma, M., Bub, J. D., Rummel, T. L., and Iwamoto, Y. 2003. Prostate cancer cell-adipocyte interaction leptin mediates androgen-independent prostate cancer cell proliferation through c-lun NH2-terminal kinase. J. Biol. Chem. 278 42660-42667. 

Li LW, Khanna M, Jo IH et al (2011) Target-specific support vector machine scoring in structure-based virtual screening computational validation, in vitro testing in kinases, and effects on lung cancer cell proliferation. J Chem Inf Model 51(4) 755-759... 

Kuriyama, I., Musumi, K., Yonezawa, Y., Takemura, M., Maeda, N., lijima, H., Hada, T., Yoshida, H. and Mizushina, Y. (2005) Inhibitory effects of glycolipids fraction from spinach on mammalian DNA polymerase activity and human cancer cell proliferation. The Journal of Nutritional Biochemistry 16(10), 594-601. 

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