Cuscutic resinoside

Cuscutic resinoside A (1 tetradecanoic acid, (115)-[[6-deoxy-3-(9-(6-deoxy-a-L-mannopyranosyl)-4-0-[(2/ ,3R)-3-hydroxy-2-niethyl-l-oxobutyl]-a-L-nianno-pyranosyl]oxy]-intramol. l,2 -ester) was obtained from the ethyl acetate-soluble fraction of a methanol extract prepared from the seeds of Cuscuta chinensis Lam. The purification of this compound employed a combination of column and preparative-scale HPLC. The structure was deduced from spectroscopic evidence and acid hydrolysis 14). The degradative process gave convolvuUnolic acid, nilic acid, and L-rhamnose. The sugar components were identified by GC analysis after being converted to their thiazolidine derivatives. This disaccharide has a unique macrocyclic lactone, which is placed between C-1 and C-2 of the first rhamnose moiety. 

Umehara K, Nemoto K, Ohkubo T, Miyase T, Degawa M, Noguchi H (2004) Isolation of a New 15-Membered Macrocyclic Glycolipid Lactone, Cuscutic Resinoside A from the Seeds of Cuscuta chinensis A Stimulator of Breast Cancer Cell Proliferation. Planta Med 70 299... 

Fig. 8.1 Glycosidic acids (cuscutic acids), unique acylated trisaccharides without cyclization to a macrolactone structurally closely related to resin glycosides (cus-1, cus-2), and a real resin glycoside (cuscutic resinoside A) from the seeds of Cuscuta spp. (clearing up of the abbreviations concerning sugar units and acyl residues see Table 8.2)...

So far there was only mention of such glycolipid monomers. They may show a very varying molecular magnitude, as low as e.g., 618 Da (cuscutic resinoside A see above) or 761 Da (ipomoeassin B, Fig. 8.3) up to 1771 Da (tuguajalapins... 

---