Breast cancer selenium

Selenium is widely sold as a dietary supplement. It is advertised to protect women from breast cancer. Write the nuclear symbol for naturally occurring selenium. It has 34 protons and 46 neutrons. 

Dorgan, J.F. et al.. Relationships of serum carotenoids, retinol, alpha-tocopherol, and selenium with breast cancer risk results from a prospective study in Columbia, Missouri (United States), Cancer Causes Control, 9, 89, 1998. 

Hunter at al. 1993). Although the data as a whole for breast cancer and tissue selenium concentrations do not support a clear chemopreventive effect for selenium, it is possible that very high selenium concentrations or very low selenium concentrations outside the ranges observed in these studies could play a role in human cancer risk (Garland et al. 1993). 

Cann SA, van Netten JP, van Netten C. 2000. Hypothesis Iodine, selenium and the development of breast cancer. Cancer Causes Control 11 121-127. 

Foster HD. 1993. The iodine-selenium connection Its possible roles in intelligence, cretinism, sudden infant death syndrome, breast cancer and multiple sclerosis. Med Hypotheses 40(l) 61-65. 

Hardell L, Danell M, Angqvist CA, et al. 1993. Levels of selenium in plasma and glutathione peroxidase in erythrocytes and the risk of breast cancer. A case control study. Biol Trace Elem Res 36(2) 99-108. 

Hunter DJ, Morris JS, Stampfer MJ, et al. 1990b. A prospective study of selenium status and breast cancer risk [see comments]. JAMA 264(9) 1128-1131. 

McConnell KP, Jager RM, Bland KI, et al. 1980. The relationship of dietary selenium and breast cancer. J Surg Oncol 15 67-70. 

Meyer F, Vereault R. 1987. Erythrocyte selenium and breast cancer risk. Am J Epidemiol 125 376-383. 

Schrauzer G, White D, Schneider C. 1976. Inhibition of the genesis of spontaneous mammary tumors in C3H mice Effects of selenium and of selenium-antagonistic elements and their possible role in human breast cancer. Bioinorg Chem 6 265-270. 

Scheauzer GN, Molenaae T, Mead S, et al. (1985) Selenium in the blood of Japanese and American women with and without breast cancer and benign breast disease. Gann 76 374. 

Hu YJ, Diamond AM. Role of glutathione peroxidase 1 in breast cancer loss of heterozygosity and allelic difference in the response to selenium. Cancer Res 2003 63 3347-3351. 

The books in this series are written with a definitive stracture to the chapters so that specific information is easily foimd, without having to read the entire chapter. For example, if a patient with breast cancer asks about the use of selenium, one can easily find cancer and efficacious doses without reading the entire chapter. 

The possible effectiveness of selenium in cancer therapy was considered as early as mid 1920s, with a paper published in 1915 on the therapeutic use of selenium in cancer [84], Following the early findings, much research has been conducted on possible protective properties of selenium against several forms of cancer, including colon cancer [85,86], lung cancer [87], nonmelanoma skin cancer [88], breast cancer [89], and prostate cancer [90-92]. The preventive effect of selenium on the development of acquired immunodeficiency syndrome (AIDS) in human immunodeficiency virus (HIV)-positive individuals has also been reported [93]. 

Support for the anticarcinogenic effects of selenium is widespread [34,35]. However, a study of Se in diet and its relation to breast cancer found no statistically significant trend for any of the indicators of selenium [36]. 

N. He, X. Shi, Y. Zhao, L. Tian, D. Wang, and X. Yang Inhibitory effects and molecular mechanisms of selenium-containing tea polysaccharides on human breast cancer MCF-7 cells, J. Agric. Food Chem., 61,579-588,2013. 

Two types of epidemiological relationships have been found in two different populations. Both relationships were inverse to selenium bioavailability and paralleled the results from animal studies. In one type of study, selenium bioavailability has been inversely related to human cancer mortality in American cities and states (14-15). Schrauzer et.al. correlated the age-adjusted mortality from cancer at 17 major body sites with the apparent dietary selenium intakes estimated from food consumption data in 27 countries (16). Significant inverse correlations were observed for cancers of the large intestine, rectum, prostate, breast, ovary, lung, and leukemia. In addition, weaker inverse associations were found for cancers of the pancreas, skin, and bladder. 

Dong Y, Ganther HE, Stewart C, ip C. identification of molecular targets associated with selenium-induced growth inhibition in human breast cells using cDNA microarrays. Cancer Res2002 62 708-714. 

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