Nerve sciatic

Relative to procaine. Data are derived from isolated frog sciatic nerve. 

Hiift-loch, n. obturator foramen, -nerv, m. sciatic nerve. 

Tamplin et. al. (54) observed that V. cholerae and A. hydrophila cell extracts contained substances with TTX-like biological activity in tissue culture assay, counteracting the lethal effect of veratridine on ouabain-treated mouse neuroblastoma cells. Concentrations of TTX-like activity ranged from 5 to 100 ng/L of culture when compared to standard TTX. The same bacterial extracts also displaced radiolabelled STX from rat brain membrane sodium channel receptors and inhibited the compound action potential of frog sciatic nerve. However, the same extracts did not show TTX-like blocking events of sodium current when applied to rat sarcolemmal sodium channels in planar lipid bilayers. 

Toews AD, Barrett C, Morell P (1998) Monocyte chemoattractant protein 1 is responsible for macrophage recruitment following injury to sciatic nerve. J Neurosci Res 53 260-267 Toggas SM, MasUah E, Rockenstein EM, Rail GF, Abraham CR, Mucke L (1994) Central nervous system damage produced by expression of the HIV-1 coat protein gpl20 in transgenic mice. Nature 367 188-189... 

In the periphery PROG and PREG may well have an important trophic action since their production in Schwann cells has been shown to result in increased myelin synthesis in regenerating rat sciatic nerve and cultured dorsal root ganglia (see Koenig et al. 1995). 

A cyclotriphosphazene-based hydraulic fluid produced no deaths, signs of neurotoxicity or histological alterations in the brain or sciatic nerve in rabbits after occluded dermal exposure at 1,000 mg/kg/day,... 

Twenty-four hours after application of 2.094 g TOCP labeled with radioactive phosphorus to a 15x20 cm area of clipped and depilated abdominal skin, radioactivity was detected in the following tissues in a dog, listed in order of decreasing concentration (counts per gram of tissue) skin and facia at site of application, liver, omental fat, blood, kidney, lung, muscle (triceps femoris), spinal cord, heart, spleen = brain = sciatic nerve, and bone (femur) (Hodge and Sterner 1943). 

In a report from the Boston Collaborative Drug Surveillance Program, pediatric nurses have reported a much higher frequency of complications from IM injections than that observed in the adult population. Twenty-three percent of pediatric nurses surveyed had observed complications (local pain, abscess, hematoma) versus a rate of 0.4% reported in adult patients [86]. Serious complications, such as paralysis from infiltration of the sciatic nerve, quadriceps myofibrosis, and accidental intra-arterial injection, are usually the... 

The intermediate-duration effects of hydrogen sulfide on neurological function were examined by the measurement of motor and sensory nerve conduction velocities of the tail nerve or morphology of the sciatic nerve (Gagnaire et al. 1986). Male Sprague-Dawley rats were exposed to 0 or 50 ppm hydrogen sulfide for 5 days a week, for 25 weeks. The study authors did not report the duration of exposure to hydrogen sulfide per day. No neurotoxic effects were observed in the rats. 

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