Somatostatin human

The production of somatostatin, human insulin, a-interferon, the growth hormone, and erythropoietin are landmarks of the recent past of genetic engineering. 

The human somatostatin gene is located on chromosome 3q28 and contains a single intron of 876 bp in its coding sequence. Its 5 upstream region includes several... 

Somatostatin. Figure 1 Somatostatin-like im mu noreactivity in neurons of the periventricular hypothalamic nucleus of the rat. Coronal brain cryostat sections have been processed for im mu nohistochemistry and sequentially incubated with a primary monoclonal mouse anti human somatostatin antibody and secondary antimouse antibody conjugated with the fluorescence-dye Cy-3. Images have been taken with a Zeiss Axioplan fluorescence microscope. Scale bar, 100 pM. 

Sun L., Fuselier J.A., Murphy W.A., Coy D.H. Antisense peptide nucleic acids conjugated to somatostatin analogs and targeted at the n-myc oncogene display enhanced cytotoxity to human neuroblastoma 1M.R.32 cells expressing somatostatin receptors. Peptides 2002 23 1557-1565. 

Patel, R. C., Lange, D. C. and Patel, Y. C. (2002). Photobleaching fluorescence resonance energy transfer reveals ligand-induced oligomer formation of human somatostatin receptor subtypes. Methods 27, 340-8. 

Somatostatin RPMC human skin stimulation of secretion (inhibition at low concn.)... 

D. C. Pimenta, M. A. Juliano, L. Juliano, Hydrolysis of Somatostatin by Human Tissue Kallikrein after the Amino Acid Pair Phe-Phe , Biochem. J. 1997, 327, 27-30. 

Teijeiro R, Bios R, Costoya JA et al (2002) Activation of human somatostatin receptor 2 promotes apoptosis through a mechanism that is independent from induction of p53. Cell Physiol Biochem 12 31-38... 

Hypothalamic hormone Human growth hormonereleasing hormone and -inhibiting hormone (somatostatin)... 

Somatostatin is a polypeptide hormone involved in regulating growth it is important in the treatment of various human growth disorders. The hormone is small, only 14 amino acids in length, making it a good candidate for cloning. In fact, it was the hrst human protein cloned in E. coli. 

---