Howard Hughes Medical Institute

Department of Chemistry and Courant Institute of Mathematical Sciences, New York University and The Howard Hughes Medical Institute, 251 Mercer Street, New York, NY 10012, U.S.A. 

We are grateful to Dr. Azat Badretdinov and Mr. Eric Feyfant for many discussions about comparative protein structure modeling. AF is a Burroughs Wellcome Fellow. RS is a Howard Hughes Medical Institute predoctoral fellow. FM is a Norman and Rosita Winston Biomedical Research Foundation Fellow. AS is a Sinsheimer Scholar and an Alfred P. Sloan Research Fellow. The investigations have also been aided by grants from NIH (GM 54762) and NSF (BIR-9601845). 

Howard Hughes Medical Institute and Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Vanderbilt University, Nashville, TN, USA... 

We are grateful to the National Institutes of Health for research support E.J. F. is supported by an NIH Research Service Award and a Ralph M. Parsons Fellowship. B. S. E. is supported by a pre-doctoral fellowship from the Howard Hughes Medical Institute. 

Howard Hughes Medical Institute http //www.hhmi.org/... 

Department of Biology, University of Utah, Salt Lake City, UT 84112 Department of Pathology, University of Utah, Salt Lake City, UT 84112 Howard Hughes Medical Institute, University of Utah, Salt Lake City, UT 84112... 

The work described in this paper was primarily supported by grants GM Ill ll from the National Institutes of General Medical Sciences, N00014-80-K-0178 from the Office of Naval Research, and the Marine Science Institute, Quezon City, Philippines. Support was also provided by grants AM 2674 (J.R.), The Howard Hughes Medical Institute (D.R.H. and S.R.W.), GM 34913 (W.R.G.), the International Foundation for Science, Stockholm, Sweden (LJ.C.), and the National Research Council of the Philippines (L J. C). 

This work was partially supported by an International Research Scholarship from the Howard Hughes Medical Institute (to G.B.) and by a collaborative research grant from Pfizer Central Research (to G.B.). Digital Equipment Corporation generously loaned the Alpha workstations used for the calculations. Riccardo Destro kindly made the l-alanine diffraction data available to us. Thanks are also due to Mark Spackman, Carlo Gatti and Eric de La Fortelle for useful discussions. 

We thank Eleanor Erikson for a critical reading of this manuscript. Work in this laboratory is supported by grants from the National Institutes of Health (GM26743 and DK28353) and by the Howard Hughes Medical Institute. 

Department of Molecular Biophysics Howard Hughes Medical Institute Rockefeller University 1230 York Avenue New York, NY 10021... 

I am grateful to Dr Oliver Griesbeck (Max Planck Institute of Neurobiology Am Klopferspitz, Martinsried, Germany) and Prof. Roger Tsien (Howard Hughes Medical Institute, University of California, San Diego, USA) for the... 

Kristi S. Anseth, Howard Hughes Medical Institute, Department of Chemical and Biological Engineering, University of Colorado, Boulder, CO 80309-0424, USA (7)... 

Work in the author s laboratory is supported in parts by the NSF, NIH, the W. M. Keck Foundation, and the Howard Hughes Medical Institute. 

Professor/Investigator, Department of Neuroscience, Howard Hughes Medical Institute The Johns Hopkins University School of Medicine 725 North Wolfe Street, PCTB 904B Baltimore, Maryland 21205... 

Howard Hughes Medical Institute—National Institutes of Health Research Scholars Program,... 

Howard Hughes Medical Institute, UCLA-DOE Institute tor Genomics and Proteomics, UCLA, Los Angeles, California 90095... 

Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024... 

Department of Biology Massachusetts Institute of Technology Whitehead Institute for Biomedical Research Howard Hughes Medical Institute Research Laboratories Cambridge, Massachusetts... 

Brunger, A. T. X-ELOR, Version 3.1 A System for X-Ray Crystallography and NMR. The Howard Hughes Medical Institute and Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, 1992. 

Tan pathology Apoptosis Neurotransmission deficits APP production inhibitors A 3-Selective regulators Phosphatase activators GSK-3 inhibitors Cdk5 inhibitors P38 inhibitors JNK inhibitors Caspase inhibitors Neurotrophic agents Phenserine tartrate Posiphen Reticulons Chaperones/SLF-CR Axonyx Axonyx/National Institutes of Health Howard Hughes Medical Institute... 

Figure 11.2 Polypeptide chains held together by hydrogen bonds, indicated by dashed lines, in a configuration called a P sheet, (a) The antiparallel P pleated sheet, (b) The parallel P pleated sheet. (Illustration, Irving Geis/Geis Archive Trust. Copyright Howard Hughes Medical Institute. Reproduced with permission.)...

The Genomics Institute of the Nopartis Research Foundation, San Diego, CA, 9212, Department of Cell Biology, The Scripps Research Institute, Ta folia, CA, 92037 and Howard Hughes Medical Institute, Department of Neurobiology and Physiology, Northwestern University, Evanston, IE 60208, USA... 

This work was supported by the NIH and the Howard Hughes Medical Institute. 

Michael Rosbash Howard Hughes Medical Institute, Department of Biology, Brandeis University, Waltham, MA 02254, USA... 

Amita Sehgal Howard Hughes Medical Institute, University of Pennsylvania Medical Center, 233 Stemmier Hall, 35th Hamilton Walk, Philadelphia,... 

How and why to keep a notebook. Procedures for use and helpful hints. http //practicingsafescience.org Advice from the Howard Hughes Medical Institute. 

For many years, die nature and location of the complex of proteins (sometimes referred to as the engine of photosynthesis) were poorly understood. During the 1980s, much more was learned as the result of research carried out by Johann Deisenhofer (Howard Hughes Medical Institute), Robert Huber, and Harmut Michel (Max Planck Institute), and for this work the investigators were awarded the 1988 Nobel Prize for chemistry. The protein complex, called the membrane-bound proteins, are difficult to define structurally because they do not crystallize readily and thus could not be subjected to x-ray crystallography. However, over a period of three years, the researchers were able to create crystals and thus were able to determine precisely the position of some 10,000 atoms in the protein complex. 

Johann Deisenhofer, Howard Hughes Medical Institute, The University of Texas, Dallas,... 

We are grateful to past and present members of our laboratory whose work we have cited in this chapter. We acknowledge the grants from the NIH, R01-DK046371 and R01-GM071442, the Robert Welch Foundation (1-1229), and past support from the Howard Hughes Medical Institute, to S.R.S. 

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