National Biomedical Research

PIR is produced by the National Biomedical Research Foundation (NBRF) [35]. 

PIR National Biomedical Research Form-dation protein sequence biblio., sub- stance, se- quence 280 000 protein sequences journals, author submis- sions National Biomedical Research Foundation free periodi- cally http //pir.geor- getown.edu... 

Each element of matrix corresponds to the probability that the amino acid in coiumn wiii mutate to the jmino acid in row j after a period of 1 PAM. The vaiues have been multipiied by 10000. (Based on Dayhoff M O 1978. Atlas of Protein Sequence and Structure Voiume 5 Suppiement 3. Dayhoff M O (Editor) Georgetown Jniversity Medicai Center, National Biomedical Research Foundation Figure 82.)... 

Dayhoff, M. O. Atlas of Protein Sequence and Structure. Silver Spring, Md. National Biomedical Research Foundation 1969. 

The National Biomedical Research Center for Advanced ESR Technology (ACERT), http / / www.acert.cornell.edu/indexfiles/acert highlight imaging 3.htm... 

Protein information resource (Barker et al., 1999) was established in 1984 by the National Biomedical Research Foundation (NBRF) as a successor to the original NBRF Protein Sequence Database, developed over 20 years by the late Margaret O. Dayhoff and published as the Atlas of Protein Sequence and Structure (Dayhoff et al., 1965 Dayhoff, 1979). Since 1988 the database has been maintained by PIR-Intemational, a collaboration between the NBRF, the Munich Information Center for Protein Sequences (MIPS), and the Japan International Protein Information Database (JIPID). 

Dayhoff, M. O. (1979). Atlas of protein sequence and structure. Vol. 5, suppl. 3 National Biomedical Research Foundation, Washington, D.C. (pp. 345-358). 

National Biomedical Research Foundation, Silver Spring, Maryland (p. 33). 

Dayhoff MO. Atlas of protein sequence and structure. The National Biomedical Research Foundation. Vol. 5, 1972. 

The PIR Protein Sequence Database (Barker et al., 2001 Wu et al., 2002) developed at the National Biomedical Research Foundation (NBRF) has been maintained by PIR-International Protein Sequence Database (PSD), which is the largest publicly distributed and freely available protein sequence database. The consortium includes PIR at the NBRF, MIPS, and JIPID. PIR-International provides online access at http //pir.georgetown.edu to numerous sequence and auxiliary databases. These include PSD (annotated and classified protein sequences), PATCHX (sequences not yet in PSD), ARCHIVE (sequences as originally reported... 

National Biomedical Research Foundation specializes in providing a database for protein primary structure. This database contains all the information from the Atlas of Protein Sequence and Structure edited by M.O. Dayhoff. In this database proteins are categorized according to their super family grouping. In addition to the primary structure information, detailed descriptions of proteins, including active site, prosthetic group, etc., are included. 

This work would not have been possible without the support of the National Library of Medicine, the National Biomedical Research Foundation in Georgetown, Washington, D.C., and the University of Texas Health Center at Tyler. The authors are grateful for their helpful discussions with Dr. Hongzhan Huang at the National Biomedical Research Foundation and for the expertise and efforts of Dr. Karen Sloan and Sara Shepherd. 

The one letter code for the amino acids is used as proposed by M. O. Dayhoff/// Atlas of Protein Sequence and Structure, National Biomedical Research Foundation, Silver Spring, Maryland A, alanine F, phenylalanine L, leucine M, methionine R, arginine W, tryptophan. 

National Biomedical Research Foundation 3900 Reservoir Road, NW Washington, DC 20007, U.S.A. 

Dayhoff, M., Schwartz, R. M., and Orcutt, B. C. (1978) A model of evolutionary change in proteins, in Atlas of Protein Sequence and Structure, (Dayhoff, M. ed.), National Biomedical Research Foundation, Silver Springs, MD, pp. 345-352. 

National Biomedical Research Foundation. Georgetown University Medical Center, 3900 Reservoir Rd., N. W. Washington, D.C. 20007,... 

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