Amyloid beta peptide

Bihel, F. Quelever, G. Lelouard, H. Petit, A. Alves de Costa, C. Pourqie, O. Checler, F. Thellend, A. Pierre, P Kraus, J.-L. Synthesis of new 3-alkoxy-7-amino-4-chloro-isocoumarin derivatives as new beta-amyloid peptide production inhibitors and their activities on various classes of protease. Bioorg. Med. Chem. 2003, 11, 3141-3152. 

Burdick D, Soreghan B, Kwon M, Kosmoski J, Rnauer M, Henschen A, Yates J, Cotman C, Glabe C. Assembly and aggregation properties of synthetic Alzheimer s A4/beta amyloid peptide analogs. J Biol Chem 1992 267 546-554. 

Shen CL, Scott GL, Merchant F, Murphy RM. Light scattering analysis of fibril growth from the amino-terminal fragment beta(l-28) of beta-amyloid peptide. Biophys J 1993 65 2383-2395. 

Tomski SJ, Murphy RM. Kinetics of aggregation of synthetic beta-amyloid peptide. Arch Biochem Biophys 1992 294 630-638. 

Kowalewski T, Holtzman DM. In situ atomic force microscopy study of Alzheimer s beta-amyloid peptide on different substrates new insights into mechanism of beta-sheet formation. Proc Natl Acad USA 1999 96 3688-3693. 

Dudek SM, Johnson GV. Transglutaminase facilitates the formation of polymers of the beta-amyloid peptide. Brain Res 1994 651 129-133. 

Howlett DR, Perry AE, Godfrey F, Swatton JE, Jennings KH, Spitzfaden C, Wadsworth H, Wood SJ, Markwell RE. Inhibition of fibril formation in beta-amyloid peptide by a novel series of benzofurans. Biochem J 1999 ... 

Khandogin J, Brooks CL III (2007) Linking folding with aggregation in Alzheimer s beta amyloid peptides. Proc Natl Acad Sci USA 104 16880-16885. 

Balbach, J. J., Ishii, Y., Antzutkin, O. N., Leapman, R. D., Rizzo, N. W., Dyda, F., Reed,J., and Tycko, R. (2000). Amyloid fibril formation by A beta 16-22, a seven-residue fragment of the Alzheimer s beta-amyloid peptide, and structural characterization by solid state NMR. Biochemistry 39, 13748-13759. 

Hertel, C., Terzi, E., Hauser, N., Jakob-Rotne, R., Seelig, J., and Kemp, J. A. (1997). Inhibition of the electrostatic interaction between beta-amyloid peptide and membranes prevents beta-amyloid-induced toxicity. Proc. Natl. Acad. Sd. USA 94, 9412-9416. 

Lashuel, H. A., Petre, B. M., Wall, J., Simon, M., Nowak, R. J., Walz, T., and Lansbury, P. T., Jr. (2002). Alpha-synuclein, especially the Parkinson s disease-associated mutants, forms pore-like annular and tubular protofibrils./. Mol. Biol. 322,1089-1102. LeVine, H. (1993). Thioflavine T interaction with synthetic Alzheimer s disease beta-amyloid peptides Detection of amyloid aggregation in solution. Protein Sci. 2, 404—410. Lin, H., Bhatia, R., and Lai, R. (2001). Amyloid beta protein forms ion channels Implications for Alzheimer s disease pathophysiology. FASEB J. 15, 2433-2444. Lorenzo, A., and Yankner, B. A. (1994). Beta-amyloid neurotoxicity requires fibril formation and is inhibited by Congo red. Proc. Natl. Acad. Sci. USA 91, 12243-12247. Luhrs, T., Ritter, C., Adrian, M., Riek-Loher, D., Bohrmann, B., Dobeli, H., Schubert, D., and Riek, R. (2005). 3D structure of Alzheimer s amyl o id-( be la) (1—12) fibrils. Proc. Natl. Acad. Sci. USA 102, 17342-17347. 

Terzi, E., Holzemann, G., and Seelig, J. (1995). Self-association of beta-amyloid peptide (1-40) in solution and binding to lipid membranes./. Mol. Biol. 252, 633-642. Terzi, E., Holzemann, G., and Seelig, J. (1997). Interaction of Alzheimer beta-amyloid peptide (1-40) with lipid membranes. Biochemistry 36, 14845—14852. 

Gregory, D. M., Benzinger, T. L., Burkoth, T. S., Miller-Auer, H., Lynn, D. G., Meredith, S. C., and Botto, R. E. (1998). Dipolar recoupling NMR of biomolecular self-assemblies Determining inter- and intrastrand distances in fibrilized Alzheimer s beta-amyloid peptide. Solid State Nucl. Magn. Reson. 13, 149-166. 

Pike, C.J., Burdick, D., Walencewicz, A.J., Glabe, C.G., and Cotman, C.W., Neurodegeneration induced by beta-amyloid peptides in vitro the role of peptide assembly state,. Neurosci., 13, 1676,1993. 

Brown RC, Cascio C, Papadopoulos V. 2000. Pathways of neurosteroid biosynthesis in cell lines from human brain regulation of dehydroepiandrosterone formation by oxidative stress and beta-amyloid peptide. J Neurochem 74 ... 

Kajkowski, E.M., Lo, C.F., Ning, X., et al. (2001) Beta-amyloid peptide-induced apoptosis regulated by a novel protein containing a G protein activation module. J. Biol. Chem., 276, 18748-18756. 

Jankowski, J.L., Fadale, D.J., Anderson, J., et al. (2004) Mutant preseniUns specifically elevate the levels of the 42 residue beta-amyloid peptide in vitro evidence for augmentation of a 42-specific gamma secretase. Hum. Mol. Genet., 13, 159-170. 

Dovey, H.F., John, V., Anderson, J.P., et al. (2001) Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain. J. Neurochem., 76, 173-181. 

Mathur C, Prasad WK, Raju VS, et al Steroids and their conjugates in the mammalian brain. Proc Natl Acad Sci USA 90 85-88, 1993 Mattes JA A pilot study of combined trazodone and tryptophan in obsessive-compulsive disorder. Int Clin Psychopharmacol 1 170-173, 1986 Mattson MP, Cheng B, Davis D, et al Beta-amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J Neurosci 12 376-389, 1992... 

Yan JJ, Cho JY, Kim HS, Kim KL, Jung JS, Huh SO, Suh HW, Kim YH, Song DK. 2001. Protection against beta-amyloid peptide toxicity in vivo with long-term administration of ferulic acid. Br J Pharmacol 133 89-96. 

Liu Q, Zhao B. 2004. Nicotine attenuates beta-amyloid peptide-induced neurotoxicity, free radical and calcium accumulation in hippocampal neuronal cultures. Br J Pharmacol 141 746-754. 

Zeng H, Chen Q, Zhao B. 2004. Genistein ameliorates beta-amyloid peptide (25-35)-induced hippocampal neuronal apoptosis. Free Radio Biol Med 36 180-188. 

Heritable and spontaneous genetic disorders represent additional applications for therapeutic ribozymes targeting cellular genes. These include the beta-amyloid peptide precursor mRNA involved in Alzheimer s disease (Currie et al., 1997 Dolzhanskaya et al., 2000), and an autosomal-dominant point mutation in the rhodopsin mRNA that gives rise to photoreceptor degeneration and retinitis pigmentosa (Hauswirth and Lewin, 2000 LaVail et al., 2000). 

Beta-amyloid peptide mRNA Block amyloid plaque formation in vitro Currie et al., 1997 Dolzhanskaya et al., 2000)... 

Currie, J.R., Chen-Hwang, M.C., Denman, R., Smedman, M., Potempska, A., Ramakrishna, N. etal. (1997) Reduction of histone cytotoxicity by the Alzheimer beta-amyloid peptide precursor. Biochim. Biophys. Acta., 1355, 248-258. 

Liu, Q., Kawai, H., and Berg, D. K. (2001). beta -Amyloid peptide blocks the response of alpha 7-containing nicotinic receptors on hippocampal neurons. Proc Natl Acad Sci USA 98, 1731 4739. 

Takenouchi, T., and Munekata, E. (1994). Inhibitory effects of beta-amyloid peptides on nicotine-induced Ca2+ influx in PC12h cells in culture. Neurosci Lett 773, 147-150. 

K.K. Kopec and R.T. Carroll, Alzheimer s beta-amyloid peptide 1-42 induces a phagocytic response in murine microglia, J. Neurochem. 71 (1998)2123-2131. 

Vigo-Pelfrey, C., Lee, D., Keim, P., Lieber-burg, I. and Schenk, D. B. (1993) Characterization of beta-amyloid peptide from human cerebrospinal fluid. J Neuroehem 61, 1965-1968. 

Auld, D. S., Kar, S. and Quiron, R. Beta amyloid peptides as direct cholinergic neuromodulators a missing link TINS 21 (1958) 43-49. 

Ambroggio, E.E., Kim, D.H., Separovic, E, et al. (2005) Surface behavior and lipid interaction of Alzheimer beta-amyloid peptide 1 12 a membrane-disrupting peptide. Biophys. J. 88, 2706-2713. 

Auld DS, Komecook TJ, Bastianetto S, Quirion R. Alzheimer s disease and the basal forebrain cholinergic system relations to beta-amyloid peptides, cognition, and treatment strategies. Prog Neurobiol 2002 68 209-245. 

Lynn, D., Conticello, V., Morgan, D.A., and Dong, J. Self-Assembling-Beta-Amyloid Peptide-Based Structures and Control of Their Self-Assembly by Changes in Metal Ions Concentration and Other Environmental Parameters, 2003-US9229 2003082900 (2003). 

Mantyh PW, Ghilardi JR, Rogers S, DeMaster E, Allen CJ, Stimson ER, Maggio JE (1993) Aluminum, iron, and zinc ions promote aggregation of physiological concentrations of beta-amyloid peptide. J Neurochem 61 1171-1174... 

Wei H, Leeds PR, Qian Y, Wei W, Chen R, Chuang D. Beta-amyloid peptide-induce death of PC12 cells and cerebellar granule cell neurons is inhibited by long-term lithium treatment. Eur J Pharmacol 2000 392 117-23. 

Muller W.E., Kirsch C., Eckert G.P. Membrane-disordering effects of beta-amyloid peptides. Biochem. Soc. Trans 2001, 29 617-623. 

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