Amyloid aggregation

Figure 1 Stages of amyloid aggregation steps in protein polymerization and the techniques used to measure them for the Alzheimer s [ peptide.

Pallitto MM, Ghanta J, Heizelman P, Kiessling LL, Murphy RM. Recognition sequence design for peptidyl modulators of beta-amyloid aggregation and toxicity. Biochemistry 1999 38 3570-3578. 

Howlett D, Cutler P, Heales S, Camilleri P. Hemin and related porphyrins inhibit beta-amyloid aggregation. FEBS Lett 1997 417 249-251. 

Roberti, M. J., Morgan, M., Pietrasanta, L., Jovin, T. M. and Jares-Erijman, E. A. (2008). Quantum dots as efficient triggers-sensors of a-synuclein amyloid aggregation in living cells, submitted. 

Amyloid aggregates of the HET-s prion protein are infectious. Proc. Natl. Acad. Sci. USA 99, 7402-7407. 

Lashuel, H. A., Petre, B. M., Wall, J., Simon, M., Nowak, R. J., Walz, T., and Lansbury, P. T., Jr. (2002). Alpha-synuclein, especially the Parkinson s disease-associated mutants, forms pore-like annular and tubular protofibrils./. Mol. Biol. 322,1089-1102. LeVine, H. (1993). Thioflavine T interaction with synthetic Alzheimer s disease beta-amyloid peptides Detection of amyloid aggregation in solution. Protein Sci. 2, 404—410. Lin, H., Bhatia, R., and Lai, R. (2001). Amyloid beta protein forms ion channels Implications for Alzheimer s disease pathophysiology. FASEB J. 15, 2433-2444. Lorenzo, A., and Yankner, B. A. (1994). Beta-amyloid neurotoxicity requires fibril formation and is inhibited by Congo red. Proc. Natl. Acad. Sci. USA 91, 12243-12247. Luhrs, T., Ritter, C., Adrian, M., Riek-Loher, D., Bohrmann, B., Dobeli, H., Schubert, D., and Riek, R. (2005). 3D structure of Alzheimer s amyl o id-( be la) (1—12) fibrils. Proc. Natl. Acad. Sci. USA 102, 17342-17347. 

Assessing the Effect of DE-Loop Mutation (D59P) in the Amyloid Aggregation Propensity of p2-Microglobulin with Molecular Dynamics Simulations... 

Soreghan B, Kosmoski J, Glabe C. Surfactant properties of Alzheimer s A/8 peptides and mechanism of amyloid aggregation. J Biol Chem 1994 269 28551-28554. 

Fig. 13.8. Correlation between expression levels and the measured aggregation rates for a set of human proteins. The aggregation rates represent all the data obtained from a comprehensive search of the amyloid aggregation literature, for studies carried out at pH values between 4.0 and 8.0. The expression levels are estimated from the cellular mRNA concentration and are taken from published databases. The standard deviations of the aggregation rates are reported only in four cases, as these values are generally not available or difficult to extract from the literature. Data for two proteins not involved in any known medical conditions are included in the plot while the other points correspond to proteins that are associated with amyloid diseases. From [4]...

AMORPHOUS AGO REBATE AMYLOID-LIKE AGGREGATE OF AMYLOID AGGREGATE... 

The mechanisms that govern apoE toxicity in the brain are not fully understood. Some proposed mechanisms include isoform specific toxicity, apoE E4-mediated amyloid aggregation, and apoE E4-mediated tau hyperphosphorylation (Huang,... 

LeVine H. Ill Thioflavin-T interaction with syndietic Alzheimers-disease beta amyloid peptides- detection of amyloid aggregation in solution. Protein Sci. 1993 2 404 10. 

Crocin is a carotenoid from the stigma of the saffron flower with many medicinal properties, including antioxidant effects. Crocin has the ability to prevent amyloid formation. The antiamy-loidogenic effect of crocin may be exerted not only by the inhibition of Ap amyloid formation but also by the disruption of amyloid aggregate [384],... 

Li et al. [386] reported a novel strategy for the self-assembly of polyoxomctalatc-pcptidc (POM P) hybrid particles as bifunctional Ap inhibitors. The two-in-one bifunctional POM P nanoparticles show an enhanced inhibition effect on amyloid aggregation in mouse CSF. 

Wang Q, Yu X, Patal K, Hu R, Chuang S, Zhang G et al (2013) Tanshinones inhibit amyloid aggregation by amyloid-p peptide, disaggregate amyloid fibrils, and protect cultured cells. ACS Chem Neurosci 4 1004-1015... 

Bemporad, F., Taddei, N., Stefani, M. and Chiti, F. (2006) Assessing the role of aromatic residues in the amyloid aggregation of human muscle acylphosphatase. Protein Sci, 15, 862-70. 

---