Photoreceptors degeneration

Jackson, GR, Owsley, C, and Curcio, CA, 2002. Photoreceptor degeneration and dysfunction in aging and age-related maculopathy. Ageing Res Rev 1, 381-396. 

Tosini, G. Menaker, M. (1998). The clock in the mouse retina melatonin synthesis and photoreceptor degeneration. Brain Res. 789, 221-8. 

Faktorovich, E. G., Steinberg, R. H., Yasumura, D., Matthes, M. and LaVail, M. M. Photoreceptor degeneration in inherited retinal dystrophy delayed by basic fibroblast growth factor. Nature 347 83-86,1990. 

Heritable and spontaneous genetic disorders represent additional applications for therapeutic ribozymes targeting cellular genes. These include the beta-amyloid peptide precursor mRNA involved in Alzheimer s disease (Currie et al., 1997 Dolzhanskaya et al., 2000), and an autosomal-dominant point mutation in the rhodopsin mRNA that gives rise to photoreceptor degeneration and retinitis pigmentosa (Hauswirth and Lewin, 2000 LaVail et al., 2000). 

Rhodopsin Block photoreceptor degeneration in vivo (Hauswirth and Lewin, 2000)... 

Jimenez, A. J., Garcia-Fernandez, J. M., Gonzalez, B. and Foster, Ik. G. (1996) The spatio-temporal pattern of photoreceptor degeneration in the aged rd/rd mouse retina. Cell Tissue Res 284, 193-202. 

Neuronal ceroid lipofuscinoses and retinal photoreceptor degeneration wind, (65-67)... 

A typical RA-receptor is the receptor fiar vitamin A (all-mtws retinol). Vitamin A is essential for pre-and postnatal development. Congenital vitamin A deficiencies are accompanied by a broad spectrum of malformations. In adult life, vitamin A is indispensable for growth, maintenance, and survival of many tissues. It is necessary for vision and reproduction. A lack of vitamin A in the adult causes night blindness and photoreceptor degeneration. But the devel-... 

Mutations in phototransduction proteins are a major cause of retinitis pigmentosa and other photoreceptor degenerations... 

Duvoisin, R. M., Zhang, C., Hamassaki-Britto, D. E., and Britto, L. R. G., Changes in expression of glutamate receptor subunits following photoreceptor degeneration in the mouse retina, Neurosci. Lett., 183, 83, 1995. 

Huang PC, Gaitan AE, Hao Y, Petters RM, Wong F. 1993. Cellular interactions implicated in the mechanism of photoreceptor degeneration in transgenic mice expressing a mutant rhodopsin gene. Proc Natl Acad Sci USA 90 8484-8488. 

Light-induced acceleration of photoreceptor degeneration in transgenic mice expressing mutant rhodopsin. Invest Ophthalmol Vis Sci 37 775-782. 

Pacione LR, Szego MJ, Ikeda S, Nishina PM, Mcinnes RR. 2003. Progress toward understanding the genetic and biochemical mechanisms of inherited photoreceptor degenerations. Annu Rev Neurosci 26 657-700. 

MODELS OF PHOTORECEPTOR DEGENERATION AND STRATEGIES FOR THEIR TREATMENT... 

Olgilvie JM, Deckwerth TL, Kundson CM, Korsmeyer SJ. Suppression of developmental retinal cell death but not of photoreceptor degeneration in Rax-deficient mice. Invest Ophthal Vis Sci 1998 39 1713-1720. 

Tao W, Wen R, Goddard MB, et al. Encapsulated cell-based delivery of CNTF reduces photoreceptor degeneration in animal models of retinitis pigmentosa. Invest Ophthalmol Vis Sci 2002 43 3292-3298. 

Liu C, Li Y, Peng M, Laties AM, Wen R. Activation of caspase-3 in the retina of transgenic rats with the rhodopsin mutation s334ter during photoreceptor degeneration. J Neurosci 1999 19 4778-4785. 

Takahashi M, Miyoshi H, Verma IM, Gage FH. Rescue from photoreceptor degeneration in the rd mouse by human immunodeficiency virus vector-mediated gene transfer. J Virol 1999 73 7812-7816. 

Kumar-Singh R, Farber D. Encapsidated adenovirus mini-chromosome-mediated delivery of genes to the retina application to the rescue of photoreceptor degeneration. Hum Mol Genet 1998 7 1893-1900. 

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