Berberine pharmacology

Umbellatine was examined by Gupta and Kahali, who found that it killed Paramoecium at 1 in 500 and Leishmania tropica at 1 in 50,000, but did not inhibit L. donovani or Entamoeba histolytica at 1 in 10,000. It remembles berberine in the nature and range of its pharmacological activity but is more active in producing cardiovascular response and is possibly more potent in the treatment of oriental sore. 

Berberine, 162, 169, 170, 171, 287, 328, 329, 331, 344, 345, 631 Berberine, quaternary ammonium bases from tetrahydro-derivative, 337 Berberine and related bases, pharmacological action, 345 syntheses, 334 Berberineacetone, 333 cptBerberine, 297 profoBerberine, 336 4-Berberines, 335 Berberinium hydroxide, 333 Berberinol, 333 Berberis spp., 328, 331, 346 Berberoline, 332 Berberonic acid, 507 Berberrubine, 329, 343 Berbine, 336 Betaine, 518 Bicucine, 170, 209... 

Abstract Protoberberine alkaloids and related compounds represent an important class of molecules and have attracted recent attention for their various pharmacological activities. This chapter deals with the physicochemical properties of several isoquinoline alkaloids (berberine, palmatine and coralyne) and many of their derivatives under various environmental conditions. The interaction of these compounds with polymorphic DNA structures (B-form, Z-form, H -form, protonated form, triple helical form and quadruplex form) and polymorphic RNA structures (A-form, protonated form, triple helical form and quadruplex form) reported by several research groups, employing various analytical techniques such as spectrophotometry, spectrofluorimetry, circular dichro-ism, NMR spectroscopy, viscometry as well as molecular modelling and thermodynamic analysis to elucidate their mode and mechanism of action for structure-activity relationships, are also presented. 

Berberine was isolated for the first time from Berberis vulgaris L. (472). The pharmacological properties of berberine resemble those of... 

With regard to pharmacology, the plants containing alkaloids of the berberine type have been studied (539-542). 

The chemistry of berberine has been reviewed.69 Several papers on the pharmacological and biochemical action of derivatives of berberine alkaloids have appeared, including studies of the adrenergic neurone-blocking action of dehydrocorydaline,70 71 the intercalation of coralyne with DNA as a possible mechanism... 

Sabir M, Bhide NK. Study of some pharmacological actions of berberine. Indian J Physiol Pharmacol 1971 15(3) lll-32. 

Berberine chloride, as well as a series of twenty other pharmacologically active agents, was evaluated in a new microplate assay for cytotoxicity using the brine shrimp Artemia salina, and shown to furnish comparable results to those previously published in the test-tube method. The assay reliably detected all of the compounds toxic to KB cells in a series of twenty-one pharmacologically active agents, except for two which required metabolic activation in humans [241],... 

It was reported that the compound 122 might be a unique nonnarcotic analgesic in view of the criteria of structure-pharmacological relations. According to the authors, it has good analgesic properties and does not possess narcotic properties characteristic of morphine (690). This has provided an incentive to the elaboration of a series of methods for the synthesis not only of this substance but of those of the berberine and the protopine type which also have analgesic properties (627, 628). 

The hypotensive and other pharmacological actions of berberine have been... 

Furuya, T. 1957. Pharmacological action, including toxicity and excretion of berberine hydrochloride and its oxidation product. Bull. Osaka Med. School 3 62-67. Cited in De Smet, P.A.G.M. 1992. Adverse effects of herbal drugs. Volume 1. New York Springer. 

Haginiwa, J., and M. Harada. 1962. [Pharmacological studies on crude drugs. V. Comparison of berberine t q)e alkaloid-containing plants on their components and several pharmacological actions.] ]pn.. Pharmacol. 82 726-731. 

Pasqual, M.S., C.P. Lauer, P. Moyna, and J.A. Henriques. 1993. Genotoxicity of the isoquinoline alkaloid berberine in prokaryotic and eukaryotic organisms. Mutat. Res. 286(2) 243-252. Peychev, L. 2005. Pharmacological investigation on the cardiovascular effects of Berberis vulgaris on tested animals. Pharmacia 52(1-2) 118-121. 

Imanshahidi, M., and H. Hosseinzadeh. 2008. Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine. Phytother. Res. 22 (8) 999-1012. 

Berberine is an isoquinoline alkaloid with several pharmacological properties [42, 43] that affect different levels of the mitochondrial fimctions [44, 45]. In mouse melanoma cells. 

The pharmacological activity of berberine and protober-berine alkaloids has been reviewed (Schiff, 1987). Berberine has a wide range of interesting biological activities. Berber-... 

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