Pharmacological investigation

Further pharmacologic investigation made possible by these sources of prostaglandins identified many areas in which the drugs might have useful activity. These, to name only a few, in-... 

From this brief review of marine vertebrate venoms, it is obvious that very few biochemical investigations have been done. The technology to study marine vertebrate venom components is available. There are simply not enough scientists interested enough to enter the field. The first task is to isolate the toxic principles and identify the amino acid sequences. Pharmacological investigation should be done on the purified toxic principle and not on the crude venom, which is a mixture of many proteins and nonproteins. 

Zschocke S, van Staden J. Cryptocarya-species substitute plants for Ocotea bullatal A pharmacological investigation in terms of cyclooxygenase-1 and -2 inhibition. J Ethnopharmacol 2000 71 473-478. 

The roots are used as an astringent, resolving anodyne and antidotal. It is also used to heal abscesses, assuage postpartum pain, and remove parasites from the skin. The plant was mentioned by Schimmel in the American Journal of Pharmacy in 1889. Clinical observation and pharmacological investigation of the sedative and hypnotic effects of the Chinese drug rhizome and root of Patrinia scabiosaefolia are discussed by Luo (43). 

Klohs MW, Keller F, Williams RE, Toekes MI, Cronheim GE. A chemical and pharmacological investigation of Piper methysticum Forst. J Med Pharm Chem 1959 1 95-103. 

Bammer, C., Pharmacological investigations of neurotransmitter involvement in passive avoidance responding a review and some new results, Neurosci. Biobehav. Rev., 6,247-296,1982. 

Cronan T, Conrad 1, Bryson R (1985) Effects of chronically administered nicotine and saline on motor activity in rats. Pharmacol Biochem Behav 22 897-899 Damaj MI, Glassco W, Marks Ml, Slobe B, James JR, May EL, Rosecrans JA, Collins AC, Martin BR (1997) Pharmacological investigation of (-F)- and (—)-c. s-2,3,3a,4,5,9b-hexahydro-l-methyl-l/7-pyrrolo-[3,2-/ ]isoquinoline, a bridged-nicotine analog, J Pharmacol Exp Ther 282 1425-1434... 

Sollman T, Brown ED. 1907. Pharmacologic investigations on thorium. Am J Physiol 18 426-456. 

Although the availability of a laboratory devoted to pharmacological investigations was important, much more was required to raise this discipline to the same prominent position occupied by other basic sciences this included the creation of chairs in pharmacology at other... 

Cyclization of the acid chloride by means of aluminum chloride gives tetralone (19-2). This is then converted to its A -methylimine (19-3) by means of methylamine and titanium tetrachloride. That intermediate is next reduced with sodium boro-hydride to give a mixture of cis and trans aminotetralins (19-4). The tmns isomer tametraline (19-5) is separated by fractional crystallization of the hydrochloride salt [20]. Detailed pharmacological investigations showed that this compound owes its antidepressant action to the inhibition of reuptake of dopamine and norepinephrine from the synaptic cleft. 

Brekhman, 1.1. and I. V. Dardymov. 1969. Pharmacological investigation of glycosides from ginseng and Eleutherococcus. Lloydia 32 46-51. 

Particle-induced coronary vasoconstriction in the rat heart Pharmacological investigation of underlying mechanisms, Thorac. Cardiovasc. Surg., 34, 316-325. 

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