Pharmacologically active agents

FIGURE 1.1 Metabolic conversion of prodrugs to pharmacologically active agents. 

No moral or ethical basis exists for the exposure of human subjects to pharmacologically active agents for purposes of demonstrations. The choice of the term demonstration in the basic reference is one of the most telling arguments contained therein. Whereas no legal basis has ever been established for experimentation on humans, nevertheless the officer and civilian physicians of the Chemical Corps feel morally, ethically and professionally Justified (both as physicians, and as professional civil and military servants of the nation) in using human subjects for research in, or under the control of, the Chemical Research and Development Laboratories. Any use of LSD-25 in which we participate will be an experiment, not a demonstration. 

Microbial metabolites contribute to the list of products as well, such as with fermentations to such major products as ethanol, acetic acid, n-butanol, or lactic acid key growth factors such as amino acids or vitamins or pharmacologically active compounds such as antibiotics, steroids, or alkaloids. Pharmacologically active agents are generally catagorized as secondary metabolites, which most often implies production in the stationary (non-growth-associated) phase of fermentation (Chap-... 

The initial chemistry carried out around the endothelin and sarafotoxin structures, by modification of the amino acid sequences, generated a range of peptide agonists. These compounds, with a wide range of relative potencies, have been used to probe the essential structural features of the natural pharmacologically active agents. 

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