Neurodegenerative disorder

Mucolipin, also known as mucolipin 1 or mucolipidin (encoded by the MCOLN1 gene), is a TRP channel-related membrane protein, most probably residing in intracellular membranes. Is defective in mucolipidosis type IV disease, a developmental neurodegenerative disorder characterized by lysosomal storage disorder and abnormal endocytosis of lipids. The fimction of mucolipin is unknown. 

New active substances for treatment of AIDS, cancer, diabetes, neurodegenerative disorders, (and from 2008) autoimmune or other immunological disorders and viral diseases. 

Heat Shock Response in Neurons and Neurodegenerative Disorders 443... 

Among the known chemokine receptors, CXCR4 has been established to play a crucial role in the nervous system physiology as evidenced by either CXCL12 or CXCR4 homozygous mutants phenotype (Ma et al. 1998 Zou et al. 1998). The other receptors discussed in this review are primarily involved in inflammatory and/ or neurodegenerative disorders which is consistent with their roles as inflammatory chemokines. 

Vesce S, Rossi D, BrambiUa L, Volterra A (2007) Glutamate release from astrocytes in physiological conditions and in neurodegenerative disorders characterized by neuroinflammation. Int Rev Neurobiol 82 57-71... 

Since therapy for AzD, like that for the other major neurodegenerative disorder Parkinsonism, could depend on establishing to what extent its pathology is associated... 

Holmberg M, Duyckaerts C, Durr A, Cancel G, Gourfinkel An I, Damier P, Faucheux B, Trottier Y, Hirsch EC, Agid Y, Brice A. Spinocerebellar ataxia type 7 (SCA7) a neurodegenerative disorder with neuronal intranuclear inclusions. Hum Mol Genet 1998 7 913-918. 

Alzheimer s disease A progressive neurodegenerative disorder and the most common type of senile dementia. It is characterised by a marked decline in cognitive functioning and severe behavioural disturbances. 

Antipsychotic, or neuroleptic drug Used in the treatment of schizophrenia. They are also used in the management of psychotic episodes associated with psychotropic drug toxicity and some neurodegenerative disorders. 

Banks WA. Physiology and pathology of the blood-brain barrier implications for microbial pathogenesis, drug delivery and neurodegenerative disorders. J Neu-rovirol 1999 5 538-555. 

Mechanisms of Neuronal Death in Neurodegenerative Disorders General Concepts... 

The machinery involved in what could be considered the initiation point is probably quite specific for each neurodegenerative disorder. On the contrary, it is largely believed that neurodegenerative diseases have in common several molecular components of the machinery involved in the later phase of cell death execution. 

Involvement of direct or indirect excitotoxicity in neurodegenerative disorders such as Huntington s disease, Parkinson s disease, and Alzheimer s disease has long been postulated on the basis of several tines of circumstantial evidence [23]. 

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