Avicel microcrystalline cellulose

NIR was used to determine the effects of changes in magnesium stearate concentration and variations in compression pressure on tablet analysis. Various types of Avicel (microcrystalline cellulose), varying mostly in particle size, were compressed into tablets with or without magnesium stearate as lubricant by using various compression pressures. Various mathematical treatments were used to either measure the differences or obviate their effects on the analysis. 

Cellulose substrates used in digestion studies were (ground) Solka Floe alpha cellulose, a non-nutritive fiber used for formulating animal diets (Gen. Biochem. Co.) Avicel, microcrystalline cellulose (American Viscose) heated milled Solka Floe (7) and (not ground) Whatman No. 1 filter paper, cotton sliver (25) and absorbent cotton (White Cross Co.). 

PMOs are supposed to be active only on (semi)ctystalline polysaccharides and not on short soluble oligosaccharides (DP 2-5). Harris et al. tried a whole variety of substrates and concluded that mixed substrates like PCS (pre-treated corn stover) generate higher activities than pure cellulose substrates like Avicel (microcrystalline cellulose) or PASC (phosphoric acid swollen cellulose).However, hemicellulose substrates do not tend to be more efficiently degraded by PMO addition. The first successful experiments with real pre-treated biomass, namely pre-treated spruce, were recently performed. ... 

The azo complexons, 3-IDA-5-R HAB (R = Me and Pr), were synthesized by Mannich condensation5 of p-hydroxyphenylazo derivatives of sulfanilic acid (HAB) with iminodiacetic acid (IDA) and formaldehyde. The crude samples of the synthesized 3-IDA-5-R-HAB were purified by cellulose column chromatography (Avicel Microcrystalline Cellulose, 1-butanol ... 

Generalizations regarding cellulose layers are easier to formulate. As noted previously, the two most popular forms of cellulose are fibrous and microcrystalline. The major supplier of fibrous cellulose is Macherey, Nagel and Co., whose main product is MN 300 cellulose. The major supplier of microcrystalline cellulose is FMC Corporation, under the trade name Avicel. Microcrystalline cellulose layers usually develop more rapidly and produce zones with lower Rt values that are more compact in size relative to fibrous cellulose layers. 

Baker-flex cellulose or Avicel microcrystalline cellulose (Analtech) precoated layers, 20 X 20 cm, used as received. 

Silica-Avicel (microcrystalline cellulose, technical grade)... 

PC-BGL and PC-HOST (as a control) toward different substrates—CMC (Na-salt of carboxymethyl cellulose), Avicel (microcrystalline cellulose), xylan (birch wood xylan), and PNPG (p-nitrophenyl-p-D-glucopyranoside)... 

Cellulose layers are produced from native, fibrous or microcrystalline cellulose (Avicel ). The separation behaviors of these naturally vary, because particle size (fiber length), surface, degree of polycondensation and, hence, swelling behavior are all different. 

Chromatography on thin layers of Avicel C (microcrystalline cellulose from American Viscose Division, F.M.C. Corp., Newark, Del.), in 1-butanol-water-acetic acid (4 5 1) with bromocresol green as indicator. Countercurrent distribution in same solvent by single withdrawal procedure with 299 transfers and 100 elements... 

Sol Preparation. Microcrystalline cellulose (Avicel PH 105) was supplied by the FMC Corporation, Philadelphia, PA., as a white powder. Twenty grams of Avicel PH 105 were mixed with 180 ml of water in a Waring blender for 5 minutes. The thick slurry was then transferred to a Lt. volumetric flask and gradually diluted to It. under constant stirring. The diluted suspension was left undisturbed for 3 days. The supernatant with a volume of about 650 ml was removed. This constituted the microcrystalline cellulose (MCC) stock sol. The solids concentration of the sols were determined by oven dry weighing and was about (1.2g/l). The unadjusted pH was 5.6. All the salts, hydrochloric acid and sodium hydroxide used were certified A.C.S. grade from Fisher Scientific. 

Microcrystalline cellulose—coarse NF powder (Avicel PH 102), FMC. Microcrystalline cellulose—medium powder (Avicel PH101), FMC. Cornstarch NF powder, bolted, National Starch Chemical. 

The first practical CSP derived from polysaccharides is cellulose triacetate (21, Figure 3.10) prepared by Hesse and Hagel in 1973.94,95 Since this derivative was prepared by the heterogeneous acetylation of native microcrystalline cellulose (Avicel) in benzene, it has been postulated that its structure is closely related to that of native cellulose (form I). This has been called microcrystalline cellulose triacetate (CTA-I). CTA-I shows characteristic chiral... 

Initially, 100% microcrystalline cellulose (MCC) (Avicel PH 200, FMC Corp. Newark, Delaware, U.S.A.) powder was used as the model compound... 

Avicel RC and CL are water-dispersible, colloidal, microcrystalline cellulose products made for use in liquid preparations. Avicel RC and CL are coprocessed mixtures of microcrystalline cellulose and sodium carboxymethylcellulose. The amount of NaCMC can be determined using the IC method. About 10 g of Nasonex and about 25 mg of NaCMC NF are separately refluxed with 30 mL of glacial acetic acid for 2 h. The refluxed mixture is transferred to a 100-mL volumetric flask and diluted to volume with purified water, and mixed. The ion chromatograph (IC) was equipped with a suppressed conductivity detector, a 4-mm CSRS suppressor, current at 50 mA, a 250 mm x 4-mm Ion CS 12A column and a 50 mm x 4 mm Ion CG 12A guard column. The mobile phase is 0.13% methanesulfonic acid in water with a flow rate of 1 mL/min. Equal... 

Microcrystalline cellulose (MCC) was obtained commercially (Avicel, PH 101, FMC, Philadelphia, PA). Amorphous microcrystalline cellulose... 

Microcrystalline Cellulose. Microcrystalline cellulose is a purified, partially depolymerized cellulose that occurs as a white, odorless, tasteless, crystalline powder composed of porous particles. It is widely used in pharmaceutical dosage forms, primarily as a filler-binder in oral tablets and capsules with both wet granulation and direct compression processes. Microcrystalline cellulose was marketed first in 1964 by the FMC Corporation under name Avicel PH in four different particle size grades, each with different properties.37 Addition of Avicel into a spray-dried lactose-based formulation overcame compressibility problems. At the same time, the lactose enhanced the flowability of the Avicel products available at that time. The direct compression tableting process became a reality, rather than a concept, partially because of the availability of Avicel. As of 2007, Avicel PH is commercially available in 10 types with different particle size, density, and moisture grades that have different properties and applications (Table 7.6).38 Other brands of microcrystalline cellulose are also available on the pharmaceutical market, including Pharmacel 101 and 102 from DMV International and Emcocel 50 M and 90 M from JRS Pharma. 

TABLE 7.6 Different Grades of Avicel PH Microcrystalline Cellulose... 

Indomethacin and paracetamol loaded spheroids/beads were prepared by a standard spheronization technique employing an Alexanderwert extruder and a Caleva spheronizer fitted with an 8.5 inch radial plate and a base spheroid composition of 50 50 microcrystalline cellulose (Avicel PH101, PMC) and Lactose BP (Wey Products Ltd), respectively. The average diameter of the spheroids was of the order of 1.1 mm as determined by light microscopy. For the SSIMS analysis the spheroids were placed in a close-packed arrangement on the sample holder secured by double sided adhesive tape. 

FMC (1993). Avicel Cellulose Gel (.Microcrystalline Cellulose) General Technology. FMC Corporation, Philadelphia, PA Novagel Cellulose Gel, FMC Corporation, Philadelphia, PA. 

In natural cellulose, the microcrystals are packed tightly in the fiber direction in a compact structure resembling bundles of wooden match sticks placed side by side. Unhinging the interconnecting chains by acid treatment does not destroy this structure. However, the unhinged crystals are now free to be dispersed by mechanical disintegration.. . . We immediately set out to explore this new avenue, developing uses for colloidal dispersions of microcrystalline celluloses, known commercially as Avicel. 

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