Tablets, Analysis

Electron microprobe analysis (EMPA) Roman Carthage curse tablet analysis, 315,317-325/ theory and application, 261,263... 

T. Wilson, Pentazocine tablet analysis using HPLC, J. Chromatogr., 243 99(1982). 

Robots are best suited (in their present form) for tedious, repetitive and humanly-hazardous jobs. Tablet analysis, immunoassay determinations, polymer solubility, etc are ideal applications. Less routine perhaps, but just as tedious, are studies of enzyme action and activity which require variation in reagents and perhaps incubation timing, the "optimisation of chemical reactions or... 

Figure 13-4 shows an example of the phenacetin standards and APC tablet analysis on a high-efficiency column. 

Rippie, E. G., and Danielsson, D. W. (1981), Viscoelastic stress/strain behaviour of pharmaceutical tablets Analysis during unloading and postcompression periods, J. Pharm. Sci., 70,476-482. 

A remarkable instance of noncompliance, with hoarding, was that of a 71-year-old man who attempted suicide and was foimd to have in his home 46 bottles containing 10 685 tablets. Analysis of his prescriptions showed that over a j>eriod of 17 months he had been expected to take 27 tablets of several different kinds daily." ... 

NIR was used to determine the effects of changes in magnesium stearate concentration and variations in compression pressure on tablet analysis. Various types of Avicel (microcrystalline cellulose), varying mostly in particle size, were compressed into tablets with or without magnesium stearate as lubricant by using various compression pressures. Various mathematical treatments were used to either measure the differences or obviate their effects on the analysis. 

Borer et al. used NIR to evaluate the key sources of variation in tablet analysis in 1998. ° The effects of active variation as well as instrumental variations were evaluated statistically. Factors such as the opening (light beam width), derivative segment size, days... 

Pharmaceuticals. In commerce, ascorbic acid is produced exclusively by synthesis (98). Because of its rather pure nature and high concentrations in vitamin-multivitamin tablets, analysis by conventional or sophisticated procedures can be performed easily. The USP provides a reference standard of L-ascorbic acid for assay purposes. The methods used can be chosen from the many discussed above. The method officially approved by the Association of Official Analytical Chemists is the micro-fluorometric procedure developed by Deutsch and Weeks (44). 

Numerous styles and brands of instruments and sample cells have been used for the analysis of tablets. The authors currently use several brands of instrumentation for tablet analysis, including filter-, diffraction grating-, and acousto-optic tunable filter-based instrumentation. Detector configurations are evolving slowly toward an optimal design however, the designs of most manufacturers are suitable for many applica-... 

The gas chromatographic method is particularly well suited for multiple analyses, which can be applied to automated techniques and individual tablet analysis. 

Optimization of the placebo tablets Analysis of the disintegration time data... 

FIGURE 5.10 Schematic of transmission experiment for tablet analysis. 

Determination of properties of film coated tablets was demonstrated by Kirsch and Drennen [73] in 1995. Here, the thickness of an ethylcellulose coating, T50 (50% dissolution time), and the hardness of the tablet were determined from NIR spectra measured on grating based and acousto-optic tunable filter (AOTF) specfiometers. While the performance of the grating based spectrometer was superior, the AOTF was demonstrated to perform adequately for most pharmaceutical applications and had the advantage of substantially shorter measurement times. This demonstration of the capacity for rapid tablet analysis was a critical step towards the implementation of such systems in an in-line tablet analysis system. 

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