Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Antivirals hepatitis

Castanospermine (67) Indolizine alkaloid MX-3253 (formerly MBI-3253 Celgosivir 6-0-butanoyl castanospermine) (68) Antiviral [Hepatitis C virus (HCV)] Inhibits a-glucosidase I Phase 11 MIGENIX (received license from Virogen Ltd., UK) 577-581... [Pg.62]

Ara-A-5 -monophosphate [29984-33-6] (ara-AMP), C2QH24N OyP, is more water-soluble than ara-A, and therefore can be used in higher dosage during the first hours of treatment of viral infections. Ara-AMP has been shown to decrease virion-associated DNA polymerase concentrations in ground squirrels carrying ground squirrel hepatitis vims. The hypoxanthine derivative, ara-HxMP [54656-49-4] (24) is more water-soluble, appears to have a similar antiviral spectmm to ara-A, and is considerably less toxic (48). [Pg.307]

Although the term nucleoside was once limited to the compounds in Table 28.2 and a few others, cunent use is more permissive. Pyrimidine derivatives of D-arabinose, for exfflnple, occur in the free state in certain sponges and are called spongonticleosides. The powerful antiviral drug ribavirin, used to treat hepatitis C and Lassa fever, is a synthetic nucleoside analog in which the base, rather than being a pyrimidine or purine, is a triazole. [Pg.1160]

Ribavirin, an antiviral agent used against hepatitis C and viral pneumonia, contains a 1,2,4-triazole ring. Why is the ring aromatic ... [Pg.544]

Viruses are small infectious agents composed of a nucleic acid genome (DNA or RNA) encased by structural proteins and in some cases a lipid envelope. They are the causative agents of a number of human infectious diseases, the most important for public health today being acquired immunodeficiency syndrome (AIDS), hepatitis, influenza, measles, and vituses causing diarrhoea (e.g., rotavirus). In addition, certain viruses contribute to the development of cancer. Antiviral drugs inhibit viral replication by specifically targeting viral enzymes or functions and are used to treat specific virus-associated diseases. [Pg.196]

Interferon alfacon-1 (Inferax ), interferon alfa-2b (IntronA ), and interferon alfa-2a (Roferon -A) are applied in the treatment of chronic hepatitis B and C and some malignancies, especially hairy cell leukemia. IFN-a proteins induce the expression of antiviral, antiproliferative and immunomodulatory genes. [Pg.411]

Li XD, Sun L, Seth RB, Pineda G, Chen ZJ (2005) Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity. Proc Natl Acad Sci USA 102 17717-17722... [Pg.23]

Meylan E, Curran J, Hofmann K, Moradpour D, Binder M, Bartenschlager R, Tschopp J (2005) Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 437 1167-1172... [Pg.23]

Approaches for the Development of Antiviral Compounds The Case of Hepatitis C Virus... [Pg.25]

Deval J, D Abramo CM, GOtte M (2006) Selective excision of non-obUgate chain-terminators by the hepatitis C virus NS5B polymerase. In 16th international HIV Drug Resistance workshop, Sitges, Spain, June 13-17, 2006. Antivir Ther 11 Suppl 1 S3 (abstract no 1)... [Pg.47]

Lin K, Pemi RB, Kwong AD, Lin C (2006) VX-950, a novel hepatitis C vims (HCV) NS3 A protease inhibitor, exhibits potent antiviral activities in HCV repUcon cells. Antimicrob Agents Chemother 50 1813-1822... [Pg.49]

Neyts J (2006) Selective inhibitors of hepatitis C vims replication. Antiviral Res 71 363-371... [Pg.49]

Reiser M, Hinrichsen H, Benhamou Y, Reesink HW, Wedemeyer H, Avendano C, Riba N, Yong CL, Nehmiz G, Steinmann GG (2005) Antiviral efficacy of NS3-seiine protease inhibitor BlLN-2061 in patients with chronic genotype 2 and 3 hepatitis C, Hepatology 41 832-835... [Pg.50]

Stuyver LJ, McBrayer TR, Tharnish PM, Clark J, Hollecker L, Lostia S, Nachman T, Grier J, Bennett MA, Xie MY, Schinazi RF, Morrey JD, Inlander JL, Furman PA, Otto MJ (2006a) Inhibition of hepatitis C replicon RNA synthesis by beta-D-2 -deoxy-2 -fluoro-2 -C-methylcytidine a specific inhibitor of hepatitis C virus replication, Antivir Chem Chemother 17 79-87... [Pg.50]

Tai CL, Chi WK, Chen DS, Hwang LH (1996) The helicase activity associated with hepatitis C virus nonstructural protein 3 (NS3). J Virol 70 8477-8484 Tong X, Chase R, Skelton A, Chen T, Wright-Minogue J, Malcolm BA (2006) Identification and analysis of fitness of resistance mutations against the HCV protease inhibitor SCH 503034. Antiviral Res 70 28-38... [Pg.52]

Nucleoside inhibitors of hepatitis C virus RNA polymerase improved potency and liver targeting with 7-deaza-7-fluoro-2 -C-methyladenosine. In Late breaker presentations. 20th international conference on antiviral research, Palm Springs, CA, USA, April 29-May 3, 2007, LB-01... [Pg.80]

Wyles DL, Schooley RT, Kaihara KA, Beadle JR, Hostetler KY (2008) Anti-hepatitis C virus repli-con activity of alkoxyalkyl esters of (S)-HPMPA and other acyclic nucleoside phosphonates. In Abstracts of the 21st international conference on antiviral research, Montreal, QC, Canada, 13-17 April 2008. Antiviral Res 78 A21, no 15... [Pg.84]

Forestier N, Reesink HW, Weegink CJ, McNair L, Kieffer TL, Chu HM, Purdy S, Jansen PL, Zeuzem S (2007) Antiviral activity of telaprevir (VX-950) and peginterferon alfa-2a in patients with hepatitis C. Hepatology 46 640-648... [Pg.104]

See other pages where Antivirals hepatitis is mentioned: [Pg.370]    [Pg.206]    [Pg.370]    [Pg.206]    [Pg.1160]    [Pg.313]    [Pg.199]    [Pg.200]    [Pg.201]    [Pg.1284]    [Pg.120]    [Pg.216]    [Pg.1]    [Pg.8]    [Pg.9]    [Pg.15]    [Pg.16]    [Pg.20]    [Pg.22]    [Pg.26]    [Pg.26]    [Pg.27]    [Pg.46]    [Pg.47]    [Pg.47]    [Pg.52]    [Pg.79]    [Pg.81]    [Pg.82]    [Pg.83]    [Pg.94]    [Pg.103]    [Pg.104]    [Pg.106]   
See also in sourсe #XX -- [ Pg.619 ]



SEARCH



Antiviral agents hepatitis

Antiviral drugs hepatitis virus

© 2024 chempedia.info