Excision, selective

This concept of reversible chemical crosslinking of the chains to drastically decrease the enthalpic penalty of the folding process and to exploit the highly favored disulfide loop formation in the A-chain with m = 4, has been further developed into artificial peptide linker chains that can be excised selectively by enzymatic processing, to allow for bioexpression of the artificial proinsulins on an industrial scale. 95,96 However, to apply this approach rationally to other double-stranded cystine peptides, knowledge about their three-dimensional structure is essential. 

Deval J, D Abramo CM, GOtte M (2006) Selective excision of non-obUgate chain-terminators by the hepatitis C virus NS5B polymerase. In 16th international HIV Drug Resistance workshop, Sitges, Spain, June 13-17, 2006. Antivir Ther 11 Suppl 1 S3 (abstract no 1)... 

John D. Corbett once said There are many wonders still to be discovered [4]. This certainly holds generally for all the different areas and niches of early transition cluster chemistry and especially for the mixed-hahde systems. The results reported above so far cover a very Hmited selection of only chloride/iodide systems and basically boron as the interstitial. Because of the very sensitive dependence of the stable stracture built in the soHd-state reaction type on parameters like optimal bonding electron counts, number of cations present, size and type of cations (bonding requirements for the cations), metal/halide ratio, and type of halide, a much larger mixed-hahde cluster chemistry can be expected. Further developments, also in mixed-hahde systems, can be expected by using solution chemistry of molecular clusters, excised from solid-state precursors. 

A single cell layer of an excised piece of onion epidermis was selected as a test object for this micro-coil, (Figure 2.1.14), and an imaging experiment was carried out, similar to the one by Mansfield et al., who used a laboratory-made micro-coil probe and gradient system [31]. Other micro-coil types, e.g., volume coils or coils that are immersed into the objects, can be adapted to specific applications and mounted on commercial imaging probes. 

Biodesulfurization (BDS) is the excision (liberation or removal) of sulfur from organosul-fur compounds, including sulfur-bearing heterocycles, as a result of the selective cleavage of carbon-sulfur bonds in those compounds by the action of a biocatalyst. Biocatalysts capable of selective sulfur removal, without significant conversion of other components in the fuel are desirable. BDS can either be an oxidative or a reductive process, resulting in conversion of sulfur to sulfate in an oxidative process and conversion to hydrogen sulfide in a reductive process. However, the reductive processes have been rare and mostly remained elusive to development due to lack of reproducibility of the results. Moderate reaction conditions are employed, in both processes, such as ambient temperature (about 30°C) and pressure. 

Wide local excision and selective postoperative therapy have been used in patients with early-stage distal carcinomas. Retrospective studies have identified patients with tumors less than 3 cm in size, limited to the superficial muscularis propria, and favorable... 

Selected Prospective and Retrospective Studies of Wide Local Excision and Adjuvant Therapy... 

Willett CG, Compton CC, Shellito PC, Efird JT. Selection factors for local excision or abdominoperineal resection of early stage rectal cancer. Cancer 1994 73 2716-2720. 

Theoretically, mutated or nonfunctional genes could be excised and replaced, and new genes with desired functions could be permanently inserted into the genome. Stable integration of an antisense DNA might also be desirable in some circumstances. Because of the technical difficulties associated with the delivery of nucleic acid-based products selectively to specific target cells in vivo, more experimental information is available for ex vivo human gene therapy. 

Vogel, E.W. (1989) Nucleophilic selectivity of carcinogens as a determinant of enhanced mutational response in excision repair-defective strains in Drosophila-, effects of 30 carcinogens. Carcinogenesis, 10, 2093-2106... 

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