Higher dosages

Ara-A-5 -monophosphate [29984-33-6] (ara-AMP), C2QH24N OyP, is more water-soluble than ara-A, and therefore can be used in higher dosage during the first hours of treatment of viral infections. Ara-AMP has been shown to decrease virion-associated DNA polymerase concentrations in ground squirrels carrying ground squirrel hepatitis vims. The hypoxanthine derivative, ara-HxMP [54656-49-4] (24) is more water-soluble, appears to have a similar antiviral spectmm to ara-A, and is considerably less toxic (48). 

Alter the chemistry of the common fluid to render it less conductive and/or less corrosive. Generally, water corrosivity increases with an increase in temperature and oxygen content and a decrease in pH. Inhibitors may he effective. Note that in mixed-metal systems, higher dosages of inhibitors may be required than would be necessary in single-metal systems in the same environment. 

Disulfiram produces a variety of adverse effects, which commonly include drowsiness, lethargy, and fatigue (Chick 1999). Other more serious adverse effects, such as optic neuritis, peripheral neuropathy, and hepatotoxicity, are rare. Psychiatric effects of disulfiram are also uncommon. They probably occur only at higher dosages of the drug and may result from the inhibition by disulfiram of a variety of enzymes in addition to ALDH. Included among the enzymes inhibited by disulfiram is dopamine P-hydroxylase, inhibition of which increases dopamine levels, which in turn can exacerbate psychotic symptoms in patients with schizophrenia and occasionally may result in psychotic or depressive symptoms in patients without schizophrenia. 

In summary, lutein supplementation has been shown to raise MPOD in the majority of subjects supplemented. In the few cases where no increases of MPOD could be observed, longer periods of supplementation (>6 months) and higher dosages (>20mg/day) may be necessary to cause significant... 

Cyclosporine is not recommended for Crohn s disease except for patients with symptomatic and severe perianal or cutaneous fistulas. The dose of cyclosporine is important in determining efficacy. An oral dose of 5 mg/kg/ day was not effective, whereas 7.9 mg/kg/day was effective. However, toxic effects limit application of the higher dosage. Dosage should be guided by cyclosporine whole-blood concentrations. 

In a number of oxide ores, cuprite (Cu20, Cu = 88.8%, SG = 5.9) is present as secondary minerals together with sulphides, malachite and tenorite. Cuprite can be floated using either sulphidization or anionic flotation methods. The flotation properties of cuprite are somewhat different from that of malachite. For example, using a sulphidization method for flotation of cuprite requires higher dosages of sulphidizer. 

From the data generated, higher dosages of NaHS are required to achieve activation of malachite. From plant and laboratory experience [13], the sulphidization method using xanthate collector is sensitive to the following, major factors ... 

Residual sprays and dusts now in use should be extended to cover more of the premises and could be used more frequently than is now common. Fogs have possibilities in certain areas if used frequently. Direct addition of safe pyrenones have much promise for bagged grain but will require a higher dosage than in the United States. 

Upon arrival at Edgewood Arsenal, each volunteer went thorough a battery of medical and psychiatric examinations. They were then placed in categories. Some were allowed to test psychoactive dmgs at the higher dosage levels. Others would be eligible only for low doses. 

Depending on their blood levels, both benzodiazepines and barbiturates produce calming and sedative effects, the former group also being anxiolytic. At higher dosage, both groups promote the onset of sleep or induce it (C). 

Respiratory and cardiovascular effects of maitotoxin have been studied in pentobarbital anaesthetized cats (21). Sublethal doses of maitotoxin induced an important hyperventilation phase, hypertension and a transitory tachycardia followed by slight bradycardia. Higher dosage caused respiratory depression, cardiac arrhythmias and tachycardia leading to cardiac failure. Artificial respiration did not modify the cardiac responses. 

The recommended doses represent a compromise between a desirable controlled reversal and the need for prompt response and adequate duration of action. Using higher dosages or shorter intervals between incremental doses may increase the incidence and severity of symptoms related to acute withdrawal such as nausea, vomiting, elevated blood pressure, and anxiety. 

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