Antithrombotic peptides

Chabance B, JoUes P, Izquierdo C, Mazoyer E, Francoual C, Drouet L, Eiat AM. (1995) Characterization of an antithrombotic peptide from kappa-casein in newborn plasma after milk ingestion. Br J Nutr 73 583-590. 

Recent studies on peptide functionalities have revealed some other beneficial health improvements such as antidiabetic, antithrombotic, hypochlesterolemic and immunomodulatory effects. In addition, it has also been reported recently that VY, one of the vasoactive and VDCC... 

Non-peptide inhibitors of thrombin (obtained by random screening procedures) include compounds based around benzothiophene (e.g. 155) and other ring systems and cyclic and linear oligocarbamate derivatives (e.g. 156). The benzothiophene derivative 155 showed antithrombotic efficacy in a rat model of thrombosis after infusion (ED50 2.3 mg/kg/h). The cyclic oligocarbamate tetramer 156 inhibited thrombin with an apparent K[ of 31 nM. 

Peptides isolated from various fish protein hydrolysates have shown a different biological activities such as antihypertensive, antioxidative, antithrombotic, and immunomodulatory activities. 

Several potent inhibitors of fibrinogen binding to gpIIb/IIIa are now known, and some have proven to be effective antithrombotic agents. These inhibitors tend either to be small cyclic peptide mimetics, in which the conformation of an RGD sequence is constrained by macrocyclization, or they are non-peptidic molecules containing functional group mimetics of the Arg and Asp side chains, held in the correct geometry for interaction with the receptor. Examples of both classes are shown in... 

CONTENTS Preface. Bruce E. Maryanoff and Cynthia A. Maryanoft. Novel An-tipsychotics with Unique D /5-HT1A Affinity and Minimal Extrapyramidal Side Effect Liability. Allen B. Reitz and Malcolm K. Scott. Antiplatelet and Antithrombotic Agents From Viper Venom Proteins, to Peptides and Peptidomimetics. to Small Organic Molecules, Peter L. Barker and Robert R. Webb. II. Discovery and Preclinical Development of the Serotonin Reuptake Inhibitor Sertraline, Willard M. Welch. Boronic Acid Inhibitors of Dipeptidyipeptidase IV A New Class of Immunosuppressive Agents, Roger J. Snow. Index. 

Trypsin K-cn f(l 12-116) Thrombin inhibitory peptide Antithrombotic Qian et al. (1995)... 

Fiat, A.-M., Migliore-Samour, D., Jolles, P., Drouet, L., Collier, C., and Caen, J. 1993. Biologically active peptides from milk proteins with emphasis on two examples concerning antithrombotic and immunomodulating activities. J. Dairy Sci. 76, 301—310. 

Newer orally active non-peptide antiplatelet/antithrombotic drags are currently being... 

ASPECT Antithrombotics in Secondary Prevention of Events in Coronary Thrombosis BNP brain (B-type) natriuretic peptide CABG coronary artery bypass graft CBC complete blood count CK creatine kinase... 

NZ bivalrudin antithrombotic Angiomax Angiox, Hirulog Synthetic peptide corresponding to the 53-64 sequence of desulfohirudin Thrombosis... 

Biologically active peptides are food-derived peptides that can exhibit diverse activities, including opiate-like, mineral binding, immunomodulatory, antimicrobial, antioxidant, antithrombotic, h)q)ocholesterolemic. 

Bioactive peptides have been defined as specific protein fragments that have a positive impact on body functions or conditions and may influence health. Upon oral administration, bioactive peptides, may affect the major body systems—namely, the cardiovascular, digestive, immune, and nervous systems. The beneficial health effects may be classified as antimicrobial, antioxidative, antithrombotic, antihypertensive, antimicrobial, and immunomodulatory [87,88]. 

Rojas-RonquUlo, R., Cruz-Guerrero, A., Flores-Najera, A., Rodriguez-Serrano, G., Gomez-Ruiz, L., Reyes-Grajeda, J. P., et al. (2012). Antithrombotic and angiotensin-converting enzyme inhibitory properties of peptides released from bovine casein by Lactobacillus casei Shirota. International Dairy Journal, 26, 147-154. 

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