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GPIIb/IIIa

GPIIb/IIIa Integrin Receptor Antagonists In the Rapid Diagnosis of Thromboembolic Events... [Pg.146]

The role of the platelet integrin GPIIb/IIIa receptor and its potential utility as a radio-diagnostic agent in the rapid detection of thromboembolic events has been demonstrated [6]. This approach may be useful for the noninvasive diagnosis of various thromboembolic disorders. [Pg.146]

Mousa SA (1999) Antiplatelet therapies from Aspirin to GPIIb/IIIa receptor antagonists and beyond. Drag Discov Today 4(12) 552-561... [Pg.146]

Mousa SA, Bozarth JM, Edwards S et al (1998) Novel technetium 99m-labeled GPIIb/IIIa receptor antagonists as potential imaging agents for venous and arterial thrombosis. Coron Artery Dis 9 131-141... [Pg.147]

GPIIb/IIIa antagonists have to be administered parenterally. They are currently used prophylactically during intracoronary interventions such as percutaneous transluminal revascularization with balloon angioplasty or intracoronary stenting, as well as to treat acute coronary syndromes like unstable angina and acute myocardial infarction. The main complications... [Pg.170]

Fibrinogen-GPIIB/IIIA. A complex responsible for aggregation of platelets in the bloodstream. [Pg.250]

CD41/61 representing the GPIIb-IIIa complex, which is a receptor for fibrinogen, von Willebrand factor, fibronectin, and vitronectin. This complex is essential for platelet aggregation. [Pg.156]

Sickle reticulocytes express the / 3 integrin GPIIb/IIIa, which binds to the high molecular weight von Willebrand factor (vWF). This complex can then... [Pg.237]

ReoPro (Abciximab, Fab fragments derived from a chimaeric Mab, directed against the platelet surface receptor GPIIb/IIIa)... [Pg.380]

Constrained templates for fibrinogen receptor (GPIIb/IIIa) antagonists 2001BML2619... [Pg.621]

Cyclic RGD peptides GPIIb/IIIa/platelets Thrombosis 94-106... [Pg.269]

Tenecteplase (TNKase) [Thrombolytic/Recombinant Tissue Plasminogen Activator] Uses Restore perfusion i mortality w/ AMI Action Thrombolytic TPA Dose 30-50 mg see Table III-l Caution [C, ], T Bleeding w/ NSAIDs, ticlopidine, clopidogrel, GPIIb/IIIa antagonists Contra Bleeding, CVA, major surgery (intracranial, intraspinal) or trauma w/in... [Pg.296]

Conformational change in GPIIb/IIIa receptor allows binding to fibrinogen through RGD and KQAGDV amino acid sequences Platelets aggregate... [Pg.239]

Glanzmann s thrombasthenia Autosomal recessive bleeding disorder absence, reduction, or dysfunction of GPIIb/IIIa complex... [Pg.245]

See other pages where GPIIb/IIIa is mentioned: [Pg.146]    [Pg.167]    [Pg.4]    [Pg.607]    [Pg.282]    [Pg.136]    [Pg.151]    [Pg.156]    [Pg.193]    [Pg.568]    [Pg.297]    [Pg.238]    [Pg.244]    [Pg.300]    [Pg.304]    [Pg.309]    [Pg.317]    [Pg.384]    [Pg.75]    [Pg.101]    [Pg.269]    [Pg.269]    [Pg.57]    [Pg.63]    [Pg.150]    [Pg.237]    [Pg.239]    [Pg.241]    [Pg.241]    [Pg.244]    [Pg.244]    [Pg.246]    [Pg.248]   
See also in sourсe #XX -- [ Pg.31 , Pg.91 ]

See also in sourсe #XX -- [ Pg.148 , Pg.149 , Pg.150 ]



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