Antimicrobial Resistance Research

The Danish Integrated Antimicrobial Resistance Monitoring and Research programme... 

Danish Integrated Antimicrobial resistance Monitoring and Research Programme (DANMAP-Denmark) Available from http //www.dairmap.org/ (30 August 2011)... 

Because of a concern that continuous application of organic acids is causing microbial resistance, research is needed on alternative application protocols and to expand the diversity of potential antimicrobials with practical application to food production. To successfully achieve this, it is essential to explore the interaction between the food matrix and food-borne pathogens (Ricke et al., 2005). 

National Center for Toxicological Research (NCTR), FDA. 3900 NCTR Road, Jefferson, AR 72079, U.S.A. URL http //www.fda. gov/nctr/index.html. Mission Statement includes fundamental and applied research specifically designed to define biological mechanisms of action underlying the toxicity of products regulated by the FDA. Covers food safety, bioterrorism, biotechnology, information technology, fundamental and applied research, premarket activities, antimicrobial resistance, and HIV/AIDS. 

M. S. Nawaz, B.D. Erickson, A.A. Khan, S.A. Khan, J.V. Pothuluri, F. Rafii, J.B. Sutherland, R.D. Wagner, C.E. Cerniglia. Human Health Impact and Regulatory Issues Involving Antimicrobial Resistance in the Food Production Environment. Regulatory Research Perspectives, 1 1-10,2001. 

Verraes, C., S. Van Boxstael, E. Van Meervenne, E. Van Coillie, P. Butaye, B. Catry, M. A. de Schaetzen, et al. Antimicrobial Resistance in the Food Chain A Review InternationalJournal (fEnvironmental Research and Public Health 10 (2013) 2643-69. 

To conduct research to better understand the emergence, persistence, and spread of antimicrobial resistance. 

Research activity in this area has mainly concentrated on the design and in vitro studies of amphiphihc helical /9-peptides with antimicrobial activity. In view of their high propensity for helical conformations as well as their resistance to proteolytic degradation, /9-peptides represent promising antibacterial candidates. 

Bacterial resistance to conventional antibiotics has become a serious problem in infection control, and has led to intensive research efforts to develop an effective novel antimicrobial agent. Antimicrobial peptides have already played a crucial role in pharmaceutical research as biomedically useful agents or as lead compounds for drug development. More specifically, cyclic peptides have shown some potential as a possible new class of... 

Research on the selective effects of antibiotic soaps on bacteria are not yet far advanced, but initial evidence suggests that they are used far too frequently, with the possible risk of producing infections resistant to the best available antibiotics. See Larson, E., A. Aiello, et al. (2003). Short- and long-term effects of handwashing with antimicrobial or plain soap in the community./oumoZ of Community Health 28(2) 139-150. 

Helicobacter infections are of great concern worldwide due to its association with peptic ulcer disease and gastric cancer. Resistance to available antimicrobials is on the rise, not only in the US but also in the developing countries. This increase in resistance has opened the door for research into... 

A major problem with antibiotics is that their overuse and improper use have led to the development of drug resistant bacteria and thus an increased number of infections with opportunistic bacteria, such as enterococci, coli-forms, pseudomonads, streptococci which are versatile and capable of becoming multidrug resistant. With this background, it may be said that searching for newer antimicrobial substances would be a promising line of research in the field of clinical microbiology. 

At present, it seems that Europe has taken the lead in the fight against antimicrobial drug resistance. At the Fourth European Conference on Antibiotic Resistance, organized by the European Commission and held in Rome in November 2003, it was strongly emphasized that only a multidisciplinary approach, involving all stakeholders—physicians, researchers, industry, politicians. 

---