Toxicological research

The threshold limit value (TLV) for cyclohexane is 300 ppm (1050 mg/m ). With prolonged exposure at 300 ppm and greater, cyclohexane may cause irritation to eyes, mucous membranes, and skin. At high concentrations, it is an anesthetic and narcosis may occur. Because of its relatively low chemical reactivity, toxicological research has not been concentrated on cyclohexane. 

P. G. Watanabe, D. G. Pegg, J. D. Burek, H. O. Yakel, and L. W. Rampy, M 90-Day Bepeated Inhalation Toxicity Study of Cumene Hydroperoxide in Bats, Toxicology Research Laboratory, EPA Document No. 868600016, Eiche No. OTS0510168, Dow Chemical USA, Midland, Mich., 1979. 

E. J. Graha, ed.. Scientific Considerations in Monitoring and Evaluating Toxicological Research, Hemisphere Publishing Corp., Washington, D.C., 1981. 

MEDLARS Medical Literature Analysis Retrieval System National Library of Medicine Carolyn llllcy MEDLARS Management Section 8600 Rockville Pike Betbesda, MD 20894 (301) 496-6193 Collection of databases containing toxicological research information and literature citations. 

A not-for-profit toxicology research institute that provides an improved scientific basis for understanding and assessing the potential adverse effects of chemicals, pharmaceuticals, and consumer preducts on human health. 

Stickel, W.H. In Ecological Toxicology Research Effects of Heavy Metal and Organochlorine Compounds, McIntyre A.D. Mills, C.F. Eds. Plenum Press New York, 1975 pp 25-74. 

Albee RR, Spencer PJ, Johnson KA, et al. 1993. Neurotoxicological examination of rats exposed to trichloroethylene vapor for 13 weeks. The Dow Chemical Company, Health and Environmental Sciences, Toxicology Research Laboratory, Midland, ML... 

Blaauboer BJ (2003) Biokinetic and toxicodynamic modelling and its role in toxicological research and risk assessment. Altern Lab Anim 31(3) 277-281... 

Mewhinney JA, Muggenburg BA. 1977. Patterns of dose after inhalation of monodisperse or polydisperse aerosols. In Boecker BB, Hobbs CH, Martinez BS, eds. Inhalation Toxicology Research Institute annual report Lovelace Biomedical and Environmental Research Institute. Albuquerque, NM Inhalation Toxicology Research Institute, 44-47. 

Some think that efforts should be made to simplify the nomenclature and to encourage industry to do proper toxicological research and supply methods for analysis before a new compound is submitted for registration. The study of antidotes should be encouraged. It is clear that research in the health hazards as well as the benefits of insecticides must be intensified and that the efforts of different laboratories should be better coordinated. Education of industry, of handlers and operators, of the medical and public health profession, and of the public must be advanced. 

Undoubtedly the establishment of toxicological research organizations will be costly, but the cost will be much less than the cost of not establishing them. There are many difficulties to be faced, but none is greater than the practical difficulties which manufacturers of modern synthetic chemicals continually face in their visions of new products or in their attempts at more economic production of well known products. 

Carpenter HM, Jenden DJ, ShulmanNR, et al. 1956. The toxicology of cellulube 220 III Experimental Toxicology Research Report. Naval Medical Research Institute, National Naval Medical Center 14 725-760. 

CIIT. 1983a. 90-Day vapor inhalation toxicity study of hydrogen sulfide in B6C3Fj mice. Report to the Chemical Industry Institute of Toxicology, Research Triangle Park, NC, by ToxiGenics, Inc. CUT docket 42063. 

Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079... 

Frazier JM (1993) In vitro models for toxicological research and testing. Toxicol Lett 68 73-90... 

Benjamin, S. A., Boecker, B. B., Lustgarten, C. S., Jones, R. K., McClellan, R. O. and Pickrell, J. A. (1974). Toxicity of inhaled 144CeCl3 in beagle dogs. VII, page 93 in Inhalation Toxicology Research Institute Annual Report 1973-1974, Report No. LF-49 (Lovelace Foundation, Albuquerque, New Mexico). 

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