Anticaries agents

The various modes of action of F as an anticaries agent have been discussed in detail elsewhere [20,21], The delivery and retention of F at, or close to, the site of action is regarded as an important feature of the successful application of the agent [22, 23], In particular, the maintenance of an elevated, even if low, F concentration adjacent to the tooth surface has long been believed to be the key to achieve optimal caries control [24],... 

Continuing the theme of saliva function, Chapter 3 describes environmental factors that affect the mineralization of hard tissue. The author describes in vitro investigations by himself and others on the relative roles of saliva and plaque fluid, and how the presence or absence of a biofilm affects the efficacy of anticaries agents. Other work focuses on the effects of lesion composition and of lesion proximity to dentine on subsequent enamel de- and remineralization behaviour. The author also discusses the importance of how the characteristics of pre-formed artificial lesions can influence subsequent mineralization behaviour in both in vitro and in situ studies. 

Classification Substituted amine salt Empincal C27H60F2N2O3 Formula C27H58N2O3 2HF Toxicology TDLo (IP, mouse) 400 mg/kg Uses Oral care agent anticaries agent in toothpaste, gels, mouthwashes... 

Toothpastes are complex mixtures of abrasives and surfactants, anticaries agents, tartar control ingredients, pH buffers, humectants, and thickeners [15]. All the ingredients must pass Food and Drug Administration regulations. 

The above example contains both antimicrobials and anticaries agents. Products sold in the trade will generally contain only the anticaries agents for reasons of cost... 

Fluorides are used as anticarie agents in toothpastes since they reduce decay by increasing the strength of teeth. Sodinm fluoride, NaF, is the most commonly used fluoride. However, the literature mentions several other sources of fluoride ions such as potassium fluoride, lithium fluoride, aluminum fluoride, zinc flnoride, sodium monofluorophosphate, acidic phosphate fluoride, ammonium fluoride, titanium tetrafluoride, and amine flnoride. 

Uses EmollienL aniimicroblal, emulsifier for personal care, pharmaceuticals, wound healing ointments, skin care, psoriasis treatmenL liq. hand soaps, ear rinses for pets penetrant for actives such as lidocaine, capsaicin Into skin emulsion stabilizer anticaries agent, plaque Inhibitor in toothpaste and mouth rinses food-contact adhesives and cellophane... 

Uses Surfactant, substantivity agent, conditioner for hand cleaners, personal care prods. corrosion inhibitor in aerosols, e.g., shaving foams bacteriostat in antidandruff shampoos, medicinal soaps anticaries agent in toothpaste solubilizer for antiseptic agents Features Mild... 

Oral Cleansing Products. Toothpastes and mouthwashes are considered cosmetic oral cleansers as long as claims about them are restricted to cleaning or deodorization. Because deodorization may depend on reduction of microbiota in the mouth, several antimicrobial agents, either quaternaries, such as benzethonium chloride [121 -54-0] or phenoHcs, such as triclosan [3380-35-5] are permitted. Products that include anticaries or antigingivitis agents or claim to provide such treatment are considered dmgs. 

Several agents deUvered via toothpaste inhibit the accumulation of dental calculus. Pyrophosphate salts, with or without a methoxyethylene—maleic acid copolymer, and zinc salts have given positive results in clinical trials (5). Pyrophosphates were added as potassium or sodium pyrophosphate or mixtures at a level of about 2—6%. The zinc salt was zinc citrate [546-46-3] (0.5—2.0%) or zinc chloride [7646-85-7] (2.0%). The products all contained fluoride in addition to the calculus inhibitor. The anticaries activity of the fluoride was not compromised (6). 

Hexyl isocyanate (338) reacted with S-methylisothiouronium iodide under basic conditions to give the isothiobiuret (339) which with the piperazine derivative (340) gave ipexidine (341), [451] Scheme 5.76.). The drug is an anticaries, antigingivitis and antiplaque agent, similar in potency and mechanism of action to chlorhexidine [452,453],... 

Uses antimicrobial agent in cosmetic and pharmaceutical creams, surgical soaps, anticaries solutions, toothpaste, mouthwash, hand and wound cleansers etc. PA. ICU A... 

Found (50% total carbohydrate content) in the honeydew produced by the sweet potato whitefly (Bemisia tabaci). Synthesised by the transferase action of yeast a-glucosidase on sucrose plus fructose. Anticaries sweetening agent. Amorph. powder. 

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