Anti-microbial agents

Bickel, H., Mertens, P., Prelog, V., Seibl. J., Walser, A. In Anti-microbial Agents and Chemotherapy, p. 1951 edited by Hobby, G. L. Ann Arbor, Mich. American Society for Microbiology 1965. 

Alarcon, J.B., Waine, G.W. and McManus, D.P. (1999) DNA vaccines technology and application as anti-parasite and anti-microbial agents. Advances in Parasitology 42, 344-410. 

The biosphere includes ecological niches where microbes peacefully co-exist with their eukaryotic host in the human this includes the concept of the micro-biome [14], which is defined as the totality of microbial organisms that co-habit with human beings. On the other hand, microbial colonization of human mucosal surfaces or prosthetic devices, often results in the development of biofilms, with significant deleterious effects on human health [15]. These are some of the challenges in infectious diseases that reflect the need to maximally utilize genomic sequence information and related sciences to better control microbial disease in human populations, and to develop anti-microbial agents with a better therapeutic index. 

Addition of anti-microbial agent, e.g sodium azide... 

Uses Intermediate in the manufacture of many chemicals (e.g., glycerine, 1,3,6-hexanediol, P-chloropropionaldehyde, 1,2,3,6-tetrahydrobenzaldehyde, P-picoline, nicotinic acid), pharmaceuticals, polyurethane, polyester resins, liquid fuel, slimicide herbicide anti-microbial agent control of aquatic weeds in irrigation canals and ditches warning agent in gases. 

Alkaloids such as berberine are known to be anti-microbial. They inhibit estarases as well as DNA and RNA polymerases. Moreover, berberine inhibits cellular respiration and acts in DNA intercalation. As a strong anti-microbial agent, berberine may be used in the treatment of AIDS, as it inhibits HIV-I reverse transcriptase. Berberine also has uses in the treatment of infections, specifically eye infections and hepatitis. 

Chopra, I. et al. (1997). The search for anti-microbial agents effective against bacteria resistant to multiple antibiotics. 

McManus, M. (1997). Mechanisms of bacterial resistance to anti-microbial agents. Am. J. Health Syst. Pharm. 54(12), 1420-1433. 

Traditionally, treatment of CGD entailed prophylactic administration of anti-microbial agents in an attempt to prevent occurrence of severe infection. However, alfected individuals still experience life-threatening infections, requiring hospitalization and intensive medical care, as often as once a year. Attempts to control these infections rely on strong anti-microbial agents and leukocyte transfusions. 

Thus far, at least one class of compound — isothiazolone derivatives — has been identified as potent IL-5 inhibitors. These substances react with a free sulphydryl group on the surface of the IL-5 receptor a-subunit, thereby preventing ligand binding. Isothiazolones are already used as anti-microbial agents, but are quite toxic. 

Nitrofurantoin, a anti-microbial agent under investigation for use in cancer therapy, also undergoes bioreduction to a nitro radical anion. Following earlier, contradictory reports, Miller et al. have re-examined the possibility that NF can oxidise GSH. Using three different methods of NF generation, the authors found no evidence for reaction between GSH and the radical.127... 

Signal pollinator attractants geographic variation multiple pollinators conditioning stimulus (T floral constancy) synergist pollinator attractants conditioning stimulus (T floral constancy) anti-microbial agents herbivore repellent synergist... 

Noise biosynthetic by-products phylogenetic artifacts neutral genetic variation herbivore repellent anti-microbial agents environmental plasticity methodological artifact biosynthetic by-products phylogenetic artifacts neutral genetic variation environmental plasticity methodological artifact... 

V. A. Pokrovskiy, V. M. Kosevich, V. L. Osaulenko, V. V. Chagovets, V. A. Pashinskaya, V. S. Shelkovskiy, V. A. Karatchevtsev, and A. Yu. Naumov, MALDI mass spectrometric study of bis-quatemary ammonium anti-microbial agent decamemetoxinuminum 2,5-dihydroxybenzoic acid, Mass Spectrom. 5(12), 183-192 (2005). 

Membranes in micro-organisms and anti-microbial agents... 

Enzymes are nowadays the labels that are most used in immunoassay. Their main disadvantage is their susceptibility to interferences due to changes in assay conditions, e.g., pH, ionic strength, content of organic solvents. The addition of anti-microbial agents such as azides or mercury derivatives also can affect the enzyme activity when using peroxidase labels [96]. The presence of other catalysts in the sample can also have an effect on the enzyme immunoassay result, e.g., Cu(II) ions promote luminol chemiluminescence in the presence of hydrogen peroxide [16]. 

Anti- tumor agents Anti- microbial agents Enzyme inhibition agents Antivirus agents Miscellaneous bioactive agents ... 

Charifson, P.S., Grossman, T.H., Mueller, P. The use of structure-guided design to discover new anti-microbial agents Focus on antibacterial resistance. Anti-Infective Agents Med. Chem. 2009, 8, 73. 

Petri WA. Anti-microbial agents. In Goodman AG, Gilman LS, eds. The Pharmacological Basis of Therapeutics, 10th ed. New York McGraw-Hill, 2001. 

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