Mercury derivatives

Acid amides have weakly amphoteric properties, and thus give salts such as CjHsCONHj.HCl with strong acids, and salts of the type C HsCONHNa with strong bases. These compounds have to be prepared at low temperatures to avoid hydrolysis, and are difficult to isolate. The mercury derivatives can, however, usually be readily prepared, because mercuric oxide is too feebly basic to cause hydrolysis of the amide, and the heavy mercuric derivatives crystallise well. 

Mercury. The fkst successful use of mercury as a fungicide occurred in 1913 (8). The fkst seed treatment compound developed was chloro(2-hydroxyphenyl)mercury [90-03-9] (1). Subsequentiy, a number of organic mercury derivatives having general formula RHgX have been used. 

The cyclized analog of meralluride is prepared by a similar synthesis. Thus, condensation of camphoric acid (42) (obtained by oxidation of camphor) with ammonia gives the bicyclic succinimide (44). Reaction with allyl isocyanate followed by ring opening and then reaction with mercuric acetate affords the mercury derivative (45) as the acetate rather than the hydroxide as above. Reaction with sodium chloride converts that acetate to the halide (46). Displacement on mercury with the disodium salt of thioglycollic acid affords the diuretic mercaptomerine (47). ... 

Craig, R. G. Biocompatibility of Mercury Derivatives , Dental Materials 2, 91-96 (1986)... 

I2 (0.0267 g, 0.21 mmol) in THF (1 mL) was added to a suspension of the mercury derivative 17 (0.0093 g. 0.016 mmol) in THF. The mixture was added to H20 (2 mL) and the resulting suspension was extracted with EtzO (2x5 mL). The combined extracts were washed with H20 (2 mL), dried (MgSQ4) and evaporated. The oily residue was submitted to flash chromatography (petroleum ether) yield 4.5 mg (89%) yellow-orange crystals mp 62 — 63 C (Et20/petroleum ether). 

Before our studies, high temperatures (>600°C) had usually been used to generate dichlorocarbene in the gas phase. Based on trapping experiments we have shown that the trihalomethyl mercury derivatives RHgCHals, which were successfully used earlier as sources of dihalocarbenes in solution (Seyferth, 1972), are also convenient precursors of carbenes in the gas phase (Mal tsev etaL, 1971a,b). 

Several structurally different types of HNLs occur in nature, which likely originated hy convergent evolution from different ancestral proteins. The enzyme from almond (PaHNL) was first crystallized in 1994 and the structure was solved by multiple wavelength anomalous dispersion of a mercury derivative. The first 3D structure analysis of PaHNL was performed in 2001. ° (7 )-PaHNL from almond uses FAD as cofactor and is related to oxidoreductases it exhibits HNL activity only in the oxidized form of FAD." ... 

Organolithium reagents have also been employed for the synthesis of novel bis(alkynyl)mercury derivatives. These include Hg(C=CCF3)263 and 46-48,64 which have been synthesized along with the bis(alkynyl)aurate analogs. Bis(alkynyl)mercury species such as 49 can also be obtained by reaction of monosubstituted alkynes with K2[Hgl4] in basic aqueous solutions.6 ... 

Formation of these dinuclear mercury derivatives is accompanied by a red shift of the absorbance of the bis(alk-ynyl) backbone. For example, conversion of 2,7-bis(alkynyl)fluorene into the corresponding bis(methylmercury) derivative 50 leads to a shift of the main absorption band of the bis(alkynyl) backbone from 505 to 567 nm. Similar results have been obtained for 51-56.67 68... 

In the elucidation of the X-ray structure of hCP by the method of isomorphous replacement, gold and mercury heavy atom derivatives were utilized. In the case of the mercury derivative, p-chloromercury-benzoate, the heavy atom bound to the free sulphydryl residue, C221, but for the gold cyanide derivative the gold atom was found to bind in the vicinity of the trinuclear copper cluster. A realistic explanation of this... 

Catalytic forms of copper, mercury and silver acetylides, supported on alumina, carbon or silica and used for polymerisation of alkanes, are relatively stable [3], In contact with acetylene, silver and mercury salts will also give explosive acetylides, the mercury derivatives being complex [4], Many of the metal acetylides react violently with oxidants. Impact sensitivities of the dry copper derivatives of acetylene, buten-3-yne and l,3-hexadien-5-yne were determined as 2.4, 2.4 and 4.0 kg m, respectively. The copper derivative of a polyacetylene mixture generated by low-temperature polymerisation of acetylene detonated under 1.2 kg m impact. Sensitivities were much lower for the moist compounds [5], Explosive copper and silver derivatives give non-explosive complexes with trimethyl-, tributyl- or triphenyl-phosphine [6], Formation of silver acetylide on silver-containing solders needs higher acetylene and ammonia concentrations than for formation of copper acetylide. Acetylides are always formed on brass and copper or on silver-containing solders in an atmosphere of acetylene derived from calcium carbide (and which contains traces of phosphine). Silver acetylide is a more efficient explosion initiator than copper acetylide [7],... 

In April 2007, the FDA approved the FI5N1 Influenza Virus Vaccine, which consists of the hemagglutinin (HA) of the virus strain AJ Vietnam/1203/2004 (clade 1) in the presence of porcine gelatin (a stabilizer) and a mercury derivative, Thimerosal (a preservative). 

Data files with diffraction data and model coordinates with crystal soaked in a mercury derivative. This derivative... 

Sodium in alcohol opens one thiophene ring of thienothiophene (2) to give 2-ethyl-3-mercaptothiophene (227), which was characterized as its mercury derivative (228) [Eq. (74)]. 

The fermentation broth of various Streptomyces species can be separated into an acidic fraction shown to contain pentalenic acid 776) The somewhat less oxidized pentalenolactone precursor has been independently prepared from humulene from which is is probably derived biogenetically Thus, treatment of humulene with mercuric nitrate followed by aqueous potassium bromide solution gave two bromo-mercury derivatives which were oxygenated in the presence of sodium borohydride. The resulting pair of diols (770 and 771) were separately converted to exo methylene... 

Fig. 15. A Weissenberg photograph of (o-amino acid pyruvate aminotransferase (mercury derivative). A single bent triangular Si(lll) monochromator and a Weissenberg camera for macromolecular crystallography were used. The oscillation angle 30° the radius of the camera 287 mm, exposure time 4.7 min...

When the mercury derivative 155 (Scheme 40) is heated with tetra-phenylcyclopentadienone, the dehydrobenzofuran 156 that is produced is trapped, and the initial adduct 157 is decarbonylated, thereby producing 1,2,3,4-tetraphenyldibenzofuran (158). ... 

L. A. Burrows, 31, 6467 (1937) An ignition composition in an electric blasting initiator, comprising at least one of the compounds selected from the group consisting of the silver and mercury derivatives of chlorinated azodicarbo-namidine USP 2086533 (1937)... 

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