Allergic disease/reactions Anaphylaxis

Several investigations have reported the ability of some natural quinones to be therapeutically useful in the treatment of asthma. The natural anthraquinone chrysophanol-8-O-P-D-glucopyranoside has potent inhibitory activity on hyaluronidase, a enzyme released from mast cells and passive cutaneous anaphylaxis reactions [311], Cheng et al. [312] described the inhibitory effect of 9,10-anthraquinone 2-carboxylic acid on immunoglobulin E-mediated passive cutaneous anaphylaxis reaction. Furthermore, these compounds are promising for treating allergic diseases with chronic and severe pruritus. Lawsone, Fig. (12), 2-hydroxy-3-(2-hydroxyethyl)-l, 4-naphthoquinone and 2,2 -methylenebis(3-hydroxy )-l,4-naphthoquinone... 

Th e dm are used cautiously during pregnancy (epinephrine and apraclonidine, Pr nancy Cat ory C dipivefrin, Piregnancy Category B) and lactation and in patients witii hypertension, diabet, hyperthyroidism, heart disease, cerebral arteriosclerosis, or bronchial asthma. Some of these dru contain sulfite that may cause allergic-like reactions (hives, wheezing, anaphylaxis) in patients with sulfite sensitivity. See Chapter 22 for information on interactions. 

Gleich, G. J., 1982, The late phase of the immunoglobulin E-mediated reaction A link between anaphylaxis and common allergic disease J. Allergy Clin. Immunol. 70 160. 

As in other allergic diseases, both patient factors and external factors contribute to fatal food-induced anaphylaxis (71). Patient factors include failure to inquire about ingredients in foods prepared by others, failure to appreciate the dose-response nature of food allergens, and denial or minimalization of symptoms based on previous nonfatal reactions. Patients may fail to carry or use injectable epinephrine or may mistakenly rely on oral antihistamine therapy for... 

Sicherer SH, Leung DY Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects. J Allergy Clin Immunol 2005 116 153. [PMID 15990789]... 

Aplastic anemias (some forms) Complications of malignancy Hypercalcemia Hematologic malignancies Acute lymphoblastic leukemia Lymphomas Multiple myeloma Immune hemolytic anemia Immune thrombocytopenia Inflammatory bowel disease Transfusion reactions Allergic and Immune Diseases Acute hypersensitivity reactions Allergic rhinitis Anaphylaxis... 

Examples Allergic rhinitis, asthma, systemic anaphylaxis Some drug allergies (eg.. penicillin) Serum sickness, Arthus reaction Tuberculin reaction, contact dermatitis (with IVc) Chronic asthma, chronic allergic rhinitis Maculopapular exanthema with eosinophilia Contact dermatitis, Maculopapular and bullous exanthema, hepatitis AQEP Beh t disease... 

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