Alcohol, disinfection

Occupational asthma caused by chlorhexidine alcohol disinfectant spray was well documented in three nurses (11). 

Chemical/Pharmaceutical/Other Class Alcohol, disinfectant... 

Nurses Soaps and detergents, alcohols, disinfectants, hand creams... 

Comprise surfactant, hydrotrope, and unsaturated terpene alcohol disinfect dishware cleaning... 

The sequential use of a chlorhexidine gluconate-containing detergent followed by an alcoholic disinfectant reduced the release of resident skin bacteria significantly better than did a sequence of unmedicated soap and alcohol used for the same periods. Paulson compared five surgical hand-scrub preparations (4% CHG brush, 2% CHG solution, povidone-iodine brush, parachlorometaxylenol brush, and alcohol-impregnated brush) [ 14]. Only the CHG products demonstrated antimicrobial effectiveness in all three parameters (immediate, persistent, and residual). A comparison also was made between a 5-minute povidone-iodine scrub and a 1 -minute povidone-iodine scrub, followed by alcohol foam [15]. The total number... 

CA Macintosh, PN Hoffman. An extended model for transfer of microorganisms via the hands differences between organisms and the effect of alcohol disinfection. J Hyg (Lond) 92(3) 345-355, 1984. 

Fingertips Adenovirus type 3 Welpas (alcoholic disinfectant) 65... 

Uses Solvent for cosmetics, hair/scalp preps., hand/face/body creams/lotions, external pharmaceuticals (not USP or NF), rubbing alcohols, disinfectants, insecticides, fungicides, other biocides, household detergents... 

Lauryl alcohol disinfectant, adhesives o-Phenylphenol disinfectant, agric. 

Amines also react with epoxides at the less substituted carbon atom. As a slightly more testing problem, suggest a synthesis of the alcohol (TM 165) whose derivatives are used in disinfectants ("phemeiide" etc.). 

Over 68 aerosol products containing isopropyl alcohol solvent have been reported (145). Aerosol formulations include hair sprays (146), floor detergents (147), shoe poHshes (148), insecticides (149,150), bum ointments (151), window cleaners, waxes and poHshes, paints, automotive products (eg, windshield deicer), insect repellents, flea and tick spray, air refreshers, disinfectants, veterinary wound and pinkeye spray, first-aid spray, foot fungicide, and fabric-wrinMe remover (152) (see Aerosols). 

Medical Usage. Isopropyl alcohol is also used as an antiseptic and disinfectant for home, hospital, and industry (see Disinfectants and antiseptics). It is about twice as effective as ethyl alcohol in these appHcations (153,154). Rubbing alcohol, a popular 70 vol % isopropyl alcohol-in-water mixture, exemplifies the medicinal use of isopropyl alcohol. Other examples include 30 vol % isopropyl alcohol solutions for medicinal liniments, tinctures of green soap, scalp tonics, and tincture of mercurophen. It is contained in pharmaceuticals, eg, local anesthetics, tincture of iodine, and bathing solutions for surgical sutures and dressings. Over 200 uses of isopropyl alcohol have been tabulated (2). 

Disinfection destroys pathogenic organisms. This procedure can render an object safe for use. Disinfectants include solutions of hypochlorites, tinctures of iodine or iodophores, phenoHc derivatives, quaternary ammonium salts, ethyl alcohol, formaldehyde, glutaraldehyde, and hydrogen peroxide (see Disinfectants AND antiseptics). Effective use of disinfected materials must be judged by properly trained personnel. 

Povidone—iodine is a brown, water-soluble powder containing approximately 10% iodine. However, the amount of free iodine, which is responsible for the antimicrobial activity, is low in a concentrated solution, but is released as the solution is diluted (41). Concentrated solutions have actually been contaminated with bacteria (42). For use as an antiseptic, povidine—iodine is diluted with water or alcohol to a concentration of 1% iodine. Detergents are added if it is used as a surgical scmb. lodophors are important as broad-spectmm antiseptics for the skin, although they do not have the persistent action of some other antiseptics. They are also used as disinfectants for clinical thermometers that have been used by tuberculous patients, for surface disinfection of tables, etc, and for clean equipment in hospitals, food plants, and dairies, much as chlorine disinfectants are used. 

Alcohols, particularly ethanol [64-17-5] and 2-propanol [67-63-9] are important disinfectants and antiseptics. In the aUphatic series of straight-chain alcohols, the antimicrobial activity increases with increasing molecular weight up to a maximum, depending on the organism tested. For Staphylococcus aureus the maximum activity occurs using amyl alcohol [71-41-0], for Salmonella typhosa, octyl alcohol [111-87-5], CgH gO (43) ioT Mycobacterium tuberculosis... 

Phenols are considered to be low-to-intermediate level disinfectants, appropriate for general disinfection of noncritical and semicritical areas. They are not sporicidal and should not be used when sterilisation is required. They are dispensed in aqueous formulations or in mixed water—alcohol solutions. Levels of 400—1300 ppm in the diluted formulation are typical. 

Poly(vinyl alcohol) is employed for a variety of purposes. Film cast from aqueous alcohol solution is an important release agent in the manufacture of reinforced plastics. Incompletely hydrolysed grades have been developed for water-soluble packages for bath salts, bleaches, insecticides and disinfectants. Techniques for making tubular blown film, similar to that used with polyethylene, have been developed for this purpose. Moulded and extruded products which combine oil resistance with toughness and flexibility are produced in the United States but have never become popular in Europe. 

Of the four halogens, iodine is the weakest oxidizing agent. Tincture of iodine, a 10% solution of I2 in alcohol, is sometimes used as an antiseptic. Hospitals most often use a product called povidone-iodine, a quite powerful iodine-containing antiseptic and disinfectant, which can be diluted with water to the desired strength. These applications of molecular iodine should not delude you into thinking that the solid is harmless. On the contrary, if I2(s) is allowed to remain in contact with your skin, it can cause painful bums that are slow to heal. 

Viruses that contain hpid are inactivated by organic solvents such as chloroform and ether. Those without hpid are resistant to these agents. This distinction has been used to classify virases. Many of the chemical disinfectants used against bacteria, e.g. phenols, alcohols and quaternary ammonium compounds (Chapter 10), have minimal virucidal activity. The most generally active agents are chlorine, the hypochlorites, iodine, aldehydes and ethylene oxide. 

Fig. 10.2 Structural formulae of alcohols used in preserving and disinfection A, 2-phenylethanol ...

In one procedure that has been widely used, the sample, after suitable treatment, is refluxed with sodium and isopropyl alcohol, after which the solution is diluted with water and the inorganic chloride is determined by standard methods (13, 54) The method has been adopted by the Association of Official Agricultural Chemists 29, 30) as a tentative one for technical DDT and for dusts, oil solutions, and aqueous emulsions of DDT, for use in the absence of other chlorine-containing compounds. The National Association of Insecticide and Disinfectant Manufacturers has also accepted the total-chlorine method for the analysis of these preparations 28). Essentially the same procedures have been described by Donovan 22), of the Insecticide Division of the Production and Marketing Administration, for technical DDT and various commercial DDT products containing no other compounds interfering with the chlorine determination. 

The basis of ultrafiltration is that a liquor is passed through a membrane many times until the required concentration of the permeate is attained. Fouling of the membrane can be a problem and regular cleaning and disinfection of the membrane is recommended. Ultrafiltration of poly(vinyl alcohol) and starch sizes offers economic advantages over... 

Surface disinfectants Compounds containing phenolics, chlorhexidine (not effective against bacteria spores), quaternary ammonium salts (additional activity if bis-n-tributyltin oxide present), hypochlorites such as household bleach, alcohols such as 70-95% ethanol and isopropyl (not effective against bacteria spores), potassium peroxymonosulfate, hydrogen peroxide, iodine/iodophores, and triclosan. 

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