Against HT-29 human colon

Discodermindol (20), a brominated aminoimidazolinylindole, from the sponge Discodermia polydiscus shows IC50 values of 1.8 pg/ml against P-388 (murine leukemia), 4.6 pg/ml against A-549 (human lung), and 12 pg/ml against HT-29 (human colon) [37]. 

Recently, Barrero et al. [20] have tested the activity of natural podolactones LL-Z1271a (63) and 68, and of synthetic derivatives 94-99, the latter being a mixture of isomers, against four tumoral cell lines P-388, A-549 (human lung carcinome), HT-29 (human colon carcinome) and MEL-28 (human melanome) (Table 2). The two natural compounds, as well as 98 showed a potent activity (ICso[Pg.470]

The polyhalogenated monoterpenes 57-59 from the Spanish sea hare Aplysia punctata show identical cytotoxic properties against P-388 mice lymphoma and HT-29 human colon carcinoma (ED50 2.5 pg/ml), A-549 human lung carcinoma and MEL-28 human melanoma cell lines (ED50 1.5 pg/ml) [57]. 

Malevamide D 137, a highly cytotoxic peptide ester from a Hawaiian marine cyanobaeterium of Symploca hydnoides, showed IC50 values of 0.3-0.7 nM (0.2-0.5 ng/mL) against P-388 (mouse lymphoma), A-549 (human lung carcinoma), and HT-29 (human colon carcinoma) cell lines and 0.7 nM against the MEL-28(human melanoma) eell line. ... 

The cytotoxicities of the 3 -difluorovinyl-taxoids 29 were evaluated in vitro against MCF7-S, MCF7-R, HT-29 (human colon carcinoma), and PANC-1 (human pancreatic carcinoma) cell lines [37], The results are summarized in Table 5.5. 

While compounds 106-108 exhibited cytotoxicity (IC50 = 1.7-2.1 pM) to P-388 mouse leukaemia, A-549 human lung carcinoma, MEL-28 human melanoma and HT-29 human colon carcinoma cell lines, only 106 showed enhanced cytotoxicity against the latter cell line (IC50 = 0.2 pM)... 

Methyl-1,3-dihydropyrrolo[ 1,2-c]thiazole-6,7-biscarbamates have been described as active compounds against murine P388 lymphocytic leukemia <87JMC2109>. Several 5-aryl-2,3-dihydro-pyrrolo[2,l-fe]thiazole-6,7-dimethanol-6,7-bis(isopropylcarbamate)s were tested for growth inhibitory activity with the HL-60 human promyelocytic leukemia cell line. The 5-phenyl, 5-(4-fluorophenyl), and 5-(3,4-dichlorophenyl) have antileukemic activity. These compounds were also cytotoxic to HT-29 human colon carcinoma cells <88JMC1427>. 

Synthesis of (-)-Haouamine A Haouamine A (193) was isolated in 2003 from a marine ascidian Aplidium haouarianum) and displayed potent and selective cytotoxic activity against the HT-29 human colon carcinoma cell Une. Aube et al. [29] have culminated a formal... 

Conicol was a meroterpenoid isolated from the ascidian Aplidium conicum collected from Tarifa Island. In Salva et al. s study, cytotoxicity assays performed on P-388 mouse lymphoma, A-549 human lung carcinoma, and HT-29 human colon carcinoma cell lines of the organic extract of A. conicum showed a moderate but selective activity against the P-388 tumor cell line with IC50 of 5 fig/mL. In addition, (-l-)-epiconicol, a marine metabolite, was isolated from Aplidium off. densum and exhibited... 

While dEpoB performed similarly to paclitaxel in sensitive tumor xenografts (MX-1 human mammary and HT-29 colon tumor), clearly superior effects of dEpoB were observed against MDR tumors under these slow infusion conditions. Thus, dEpoB (6 h, Q2D, 30 mg/kg x 5 doses, i.v.) demonstrated a foil curative effect when administered to nude mice bearing the resistant human lymphoblastic T-cell leukemia,... 

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