Cytotoxic peptides

Defensins are a group of antimicrobial and cytotoxic peptides made by immune cells. There are seven defensins in humans, six alpha-defensins and one beta-defensin, which are involved in the innate immune defense at the surface of epithelia from the respiratory tract, the intestinal tract or the urinary tract. 

Standley SM, Toft DJ, Cheng H et al (2010) Induction of cancer cell death by selfassembling nanostructures incorporating a cytotoxic peptide. Cancer Res 70 3020-3026... 

Halicylindramides - antifungal peptides Polydiscamide A - cytotoxic peptides... 

H Fungi - Amanita phalloides and Agaricus phalloides Cyanobacteria -Lyngbya majuscula Phalloidin, phallicidin, and amanitin - toxic peptides Majusculamide D - cytotoxic peptide Microcolin A - peptide with immunosuppressive, antileukemic and protein kinase C inhibitory activity 242... 

H Isolated from Callipelta sp. Callipeltin B - cytotoxic peptide 242, 253... 

Talpir R, Benayahu Y, Kashman Y. Pannell L, Schleyer M. (1994) Hemiasterlin and geodiamolide TA two new cytotoxic peptides from the marine sponge HemiastereUa minor (Kirkpatrick). Tetrahedron Lett 35 4453 456. 

Anderson HJ, Coleman JE, Andersen RJ, Roberge M. (1997) Cytotoxic peptides hemiasterlin, hemiasterlin A and hemiasterlin B induce mitotic arrest and abnormal spindle formation. Cancer Chemother Pharmacol 39 223-226. 

Maru, N., Ohno, O., and Uemura, D. (2010c). Lyngbyacyclamides A and B, novel cytotoxic peptides from marine cyanobacteria Lyngbya sp. Tetrahedron Lett. 51,6384-6387. 

Teruya, T., Sasaki, H., Fukazawa, H., and Suenaga, K. (2009). Bisebromoamide, a potent cytotoxic peptide from the marine Cyanobacterium Lyngbya sp. Isolation, stereostructure, and biological activity. Org. Lett. 11, 5062-5065. 

Three cytotoxic peptides, patellamide D (31) and lissoclinamides 4-5 (32-33) were isolated from a Great Barrier Reef specimen of L. patella and identified by interpretation of spectral data. The peptides were found within the obligate algal symbiont of the genus Prochloron [65]. Another study of the same Australian L. patella reported lissoclinamide 6 (34), in addition to lissoclinamides 4-5 (32-33) and patellamide D (31). The structure of patellamide D (31) was obtained by X-ray crystallography and its conformation compared with those obtained by molecular modelling [66]. Patellamide D (31) has been reported to be a... 

Oriamide (441), a cytotoxic peptide containing the unusual amino acid, 4-propenoyl-2-tyrosylthiazole, was isolated from a Theonella sp. from South Africa [367]. Theonella cupola from Indonesia and from... 

Coleman JE, de Silva ED, Kong F, Andersen RJ, Allen TM (1995) Cytotoxic Peptides from the Marine Sponge Cymbastela sp. Tetrahedron 51 10653... 

Schally, A. V. and Nagy, A. (1999) Cancer chemotherapy based on targeting of cytotoxic peptide conjugates to their receptor on tumours. Eur. J. Endocrinol. 141, 1-14. 

Malevamide D 137, a highly cytotoxic peptide ester from a Hawaiian marine cyanobaeterium of Symploca hydnoides, showed IC50 values of 0.3-0.7 nM (0.2-0.5 ng/mL) against P-388 (mouse lymphoma), A-549 (human lung carcinoma), and HT-29 (human colon carcinoma) cell lines and 0.7 nM against the MEL-28(human melanoma) eell line. ... 

A new cytotoxic peptide named tasiamide B 142, which displayed an IC50 value of 0.8 pM against KB cells in bioactivity, was isolated from the marine cyanobacterium Symploca sp. ... 

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