Discodermia polydiscus

Discodermindol (20), a brominated aminoimidazolinylindole, from the sponge Discodermia polydiscus shows IC50 values of 1.8 pg/ml against P-388 (murine leukemia), 4.6 pg/ml against A-549 (human lung), and 12 pg/ml against HT-29 (human colon) [37]. 

An Antarctica collection of the sponge Psammopemma sp. has yielded the new 4-hydroxyindole alkaloids, psammopemmins A (1378), B (1379), and C (1380), which embody the unique 2-bromopyrimidine unit (1337). The related meridia-nins B (1381), C (1382), D (1383), E (1384), and F (1385) were found in the tunicate Aplidium meridianum collected at 100 m near the South Georgia Islands (1338,1339). These protein kinase inhibitors have been synthesized (1340). The sponge Discodermia polydiscus has afforded 6-hydroxydiscodermindole (1386) (1341). 

Cohen J, Paul GK, Gunasekera SP, Longley RE, Pomponi SA (2004) 6-Hydroxydiscoder-mindole, a New Discodermindole from the Marine Sponge Discodermia polydiscus. Pharm Biol 42 59... 

Imidazole alkaloids Discodermia polydiscus CHCl3-MeOH H2O (5 10 6) HSCCC... 

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