Prostate adenocarcinoma

Prostate adenocarcinomas Prostate specific antigen (PSA) (25) Prostatic acid phosphatase (PAP)... 

Gupta S, Srivastava M, Ahmad N, et al. Over-expression of cyclooxygenase-2 in human prostate adenocarcinoma. Prostate 2000 42 73-78. 

M13. Maygarden, S. I., Strom, S., and Ware, I. L., Localization of epidermal growth factor receptor by immunohistochemical methods in human prostatic adenocarcinoma, prostatic intraepithelia neoplasia, and benign hyperplasia. Arch. Pathol. Lab. Med. 116, 269-273 (1992). 

Accetta PA, Gardner WA. Squamous metastases from prostatic adenocarcinoma. Prostate. 1982 3 515. 

Gupta, S., Srivastava, M., Ahmad, N., Bostwick, D.G., and Mukhtar, H. (2000) Over-Expression of Cyclooxygenase-2 in Human Prostate Adenocarcinoma, Prostate 42,73-78. 

A new guaianolide derivative, which possesses cytotoxic activity, was obtained from leaves and stems of Chrysanthemum boreale. It is effective in kidney carcinoma, melanoma, colon adenocarcinoma, prostate adenocarcinoma, and lung carcinoma. Chrysanthemum morifolium effectively inhibited the cytotoxicity and improved cell viability. It also stimulates the elevation of reactive oxygen species (ROS) level, increase in Bax/Bcl-2 ratio, cleavage of caspase-3, and PARP proteolysis [43, 44]. 

The normal prostate is composed of acinar secretory cells arranged in a radial shape and surrounded by a foundation of supporting tissue. The size, shape, or presence of acini are almost always altered in the gland that has been invaded by prostatic carcinoma. Adenocarcinoma, the major pathologic cell type, accounts for more than 95% of prostate cancer cases.15 Much rarer tumor types include small cell neuroendocrine cancers, sarcomas, and transitional cell carcinomas. 

Canene-Adams, K., B. L. Lindshield, S. Wang et al. 2007. Combinations of tomato and broccoli enhance antitumor activity in dunning r3327-h prostate adenocarcinomas. Cancer Res 67(2) 836-843. 

Interestingly, while it has been reported that the inhibition of cell growth by carotenoids in colon (Palozza et al., 2001b, 2007a) as well as in prostate (Williams et al., 2000) adenocarcinoma cancer cells was independent of p53 and p21 status, HL-60 cells increased their p21 expression as a consequence of the treatment with p-carotene (Palozza et al., 2002b). In addition, the antiproliferative effects of P-carotene required p21 expression in human fibroblasts (Stivala et al., 2000). In contrast, mammary and endometrial cancer cells decreased p21 levels, following lycopene treatment (Nahum et al., 2001). 

The normal prostate is composed of acinar secretory cells that are altered when invaded by cancer. The major pathologic cell type is adenocarcinoma (more than 95% of cases). 

Tables 8 and 9 show how some of the previously mentioned antibodies can distinguish between metastatic adenocarcinomas of unknown primaries in females and males, respectively. The panels are similar except for ERP (estrogen receptor protein), GCDFP-15, and S-100, which are used in females for their specificity for gynecologic tumors and PSA (prostatic specific antigen), used in males for its specificity for prostatic adenocarcinoma. These antibodies cannot absolutely distinguish among the tumor sources listed. However, they can guide pathologists and clinicians on which organs need to be further examined to determine the primary source of a metastatic tumor.

Mokhtari MJ, Motamed N, Shokrgozar MA. (2008) Evaluation of silibinin on the viability, migration and adhesion of the human prostate adenocarcinoma (PC-3) cell line. Cell Biol Int 32 888-892. 

Kim TG Hwi KK, Hung CS. (2005) Morphological and biochemical changes of andrographolide induced cell death in human prostatic adenocarcinoma PC-3 cells. In Vivo 19 551-557. 

Premenopausal use There is no indication for premenopausal use of raloxifene. Hepatic function impairment Raloxifene was studied, as a single dose, in Child-Pugh class A patients with cirrhosis and serum total bilirubin ranging from 0.6 to 2 mg/dL. Plasma raloxifene concentrations were approximately 2.5 times higher than in controls and correlated with total bilirubin concentrations. Safety and efficacy have not been evaluated further in patients with severe hepatic insufficiency. Carcinogenesis In long term carcinogenicity studies in animals there was an increased incidence of ovarian tumors, testicular interstitial cell tumors, and prostatic adenocarcinomas. 

Detection/staging/ follow-up of prostate adenocarcinoma Prevention of blood clots... 

Adenocarcinoma of the prostate is one of the most common malignant tumors in adult males. For advanced disease palliative hormonal therapy has been... 

Fluorouracil is used in several combination regimens in the treatment of breast cancer. It also has palliative activity in gastrointestinal adenocarcinomas, including those originating in the stomach, pancreas, liver, colon, and rectum. Other tumors in which some antitumor effects have been reported include carcinomas of the ovary, cervix, oropharynx, bladder, and prostate. Topical 5-fluorouracil cream has been useful in the treatment of premalignant keratoses of the skin and superficial basal cell carcinomas, but it should not be used in invasive skin cancer. 

Doxorubicin is one of the most effective agents used in the treatment of carcinomas of the breast, ovary, endometrium, bladder, and thyroid and in oat cell cancer of the lung. It is included in several combination regimens for diffuse lymphomas and Hodgkin s disease. Doxorubicin can be used as an alternative to daunorubicin in acute leukemias and is useful in Ewing s sarcoma, osteogenic sarcoma, soft-tissue sarcomas, and neuroblastoma. Some activity has been reported in non-oat cell lung cancer, multiple myeloma, and adenocarcinomas of the stomach, prostate, and testis. 

Breast, ovarian, cervical, bladder and prostate cancer gastrointestinal adenocarcinomas Metastatic pancreatic cancer small cell lung cancer Leukemia Breast cancer... 

Bjermer, and R. Henriksson. Effects of tobacco smoke on tumor growth and radiation response of dunning R3327 prostate adenocarcinoma in rats. Prostate 2000 42(4) 253-259. 

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