Serum total bilirubin

Hyperbilirubinemia Abnormally high concentrations of the bile pigment bilirubin in the bloodstream. Hyperbilirubinemia is defined as a total serum bilirubin level greater than 5 mg/dL. 

Adverse reactions occurring in at least 3% of patients include abdominal pain nausea diarrhea vomiting headache dizziness pruritus nephrolithiasis/urolithiasis back pain fever increased ALT, AST, and total serum bilirubin decreased neutrophils. 

The following morning, nearly 24 h later, the change-of-shift nurse noted that the child appeared to be jaundiced, with the whites of the eyes appearing yellow and the skin yellow to the level of the chest. Following the nursery protocol, repeat laboratory screening values were obtained. These tests showed the following values hematocrit 45% total serum bilirubin 7 mg/dL cord blood type A and positive Coombs antibody test. The child s pediatrician was informed of the results. 

Diagnosis of the cause of hyperbilirubinemia is made by (1) evaluating the total serum bilirubin... 

Unfortunately, visual assessment has not been correlated with actual bilirubin levels. Therefore, laboratory measurement of the actual total serum bilirubin levels is mandatory. The timing of these measurements becomes important because of the bilirubin load and level of maturation of bilirubin-UDP-glucuronyltransferase. 

Jaundice indicates that the total serum bilirubin is raised above 50 pmol/L in adults or 80 pmolfL in neonates. 

A 54-year-old asthmatic man developed subacute hepatitis and hepatic encephalopathy while taking zafirlukast 20 mg bd for 8 months and co-amoxiclav 2 g/day for a few days (3). He also took antihistamines, inhaled glucocorticoids, and beta-blockers (not specified). A percutaneous liver biopsy showed severe hepatocellular necrosis and eosinophilic infiltrates without prominent cholestasis. Raised transaminases and total serum bilirubin normalized within 3 months after withdrawal of zafirlukast and co-amoxiclav and the use of intermittent, high-dose, parenteral glucocorticoids, followed by oral tapering. 

BiliCheck and Minolta Jaundice Meter JM-102 for estimating total serum bilirubin in a normal newborn population. J Perinatol 2002 22 12M. 

C. Lu, G.-Q. Song, J.-M. Lin, C.-W. Huie, Enhancement in sample preconcentration by the on-line incorporation of cloud point extraction to flow injection analysis inside the chemiluminescence cell and the determination of total serum bilirubin, Anal. Chim. Acta 590 (2007) 159. 

This concept has now been largely abandoned in favor of more suitable methods for making this distinction, but it is of interest to re-examine it with more specific analytical methods than were available when the concept was popular. Table VII gives the results of comparing serum bile salt concentrations with total serum bilirubin concentrations and shows that jaundice with... 

Predisposing fiictors. The search for possible factors contributing to radioembolization induced liver toxicity has shown that the best pre-treatment risk indicator of liver toxicity is the total serum bilirubin level. There is a direct relationship between the pre-treatment total bilirubin value and risk of liver toxicity [11]. Radiation dose is also associated with the risk of liver toxicities, with doses ranging up to 150 Gy per treatment. It is not known how previous embolizing treatments (TAE and TACE) may influence radioembolization induced liver toxicity, however, concomitant chemotherapy with the... 

In general, transaminases are only mildly increased, and deep jaundice combined with mild elevation of liver enzymes should raise the suspicion for fulminant Wilson disease. However, increases of transaminases may be indistinguishable from findings seen in acute hepatitis. Sometimes alkaline phosphatase activities are relatively low in patients with Wilson disease. A ratio of total serum bilirubin concentration and alkaline phosphatase activity (>2) may differentiate fulminant Wilson disease from other forms of fulminant hepatic failure. However, the usefulness of this test was not confirmed in larger series. 

Hemoglobin Reticulocyte count Serum bilirubin (total) Serum bilirubin (indirect) Serum haptoglobin Serum iron Urinary iron Fecal stercobilinogen... 

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