Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Activity on blood pressure

Accordingly, a number of components have been isolated from the fhiit of Randia siamensis and their structures established. A preliminary study found that an alcohol extract of the fruit of R. siamensis caused a significant uterine contraction in vivo. Thus the major component isolated in this study was examined for its in vivo activity on blood pressure, heart rates and spontaneous uterine contractility. [Pg.163]

Needles. M.p. 246-50° decomp. Sol. HjO. [ ]d +21°. Reacts strongly alkaline Exerts depressor activity on blood pressure. [Pg.408]

Modern representations of the virtual heart, therefore, describe structural aspects like fibre orientation in cardiac muscle, together with the distribution of various cell types, active and passive electrical and mechanical properties, as well as the coupling between cells. This then allows accurate reproduction of the spread of the electrical wave, subsequent contraction of the heart, and effects on blood pressure, coronary perfusion, etc. It is important to point out, here, that all these parameters are closely interrelated, and changes in any one of them influence the behaviour of all others. This makes for an exceedingly complex system. [Pg.137]

For example, if two treatments (a phytochemical product vs a placebo) are being evaluated to assess the influence of the active product on blood pressure, half of the subjects might be in the active-placebo sequence and the other half in the placebo-active sequence. If the active product lowered blood pressure and the effect continued after the treatment was stopped, then blood pressure might be lower during the placebo period for subjects in the active-placebo sequence than would be the case for those in the placebo-active sequence. This might be detected as a lower level of blood pressure before the start of the second treatment among subjects in the active-placebo treatment. [Pg.241]

The antioxidant property of ferulic acid and related compounds from rice bran was reported by Kikuzaki et al, (2002). Their results indicated that these compounds elicit their antioxidant function through radical scavenging activity and their affinity with lipid substrates. Another recent study reported by Butterfield et al, (2002) demonstrated that ferulic acid offers antioxidant protection against hydroxyl and peroxyl radical oxidation in synaptosomal and neuronal cell culture systems in vitro. The effect of ferulic acid on blood pressure (BP) was investigated in spontaneously hypertensive rats (SHR). After oral administration of ferulic acid the systolic blood pressure (SBP) decreased in a dose-dependent manner. There was a significant correlation between plasma ferulic acid and changes in the SBP of the tail artery, suggesting... [Pg.361]

Two rather broad structural classes account for the large majority of drugs that have proven useful in the clinic for treating depression. Each of these has associated with it some clearly recognized side effects the monoamine oxidase inhibitors, most commonly derivatives of hydrazine, tend to have undesirable effects on blood pressure the tricyclic compounds on the other hand may cause undesirable changes in the heart. Considerable effort has thus been expended toward the development of antidepressants that fall outside those structural classes. An unstated assumption in this work is the belief that very different structures will be associated with a novel mechanism of action and a different set of ancillary activities. One such compound, trazodone... [Pg.472]

Effects on blood pressure, heart rate, lead II ECG, core body temperature, and locomotor activity can be explored using DataSciences telemetry implanted devices in rats, guinea-pigs, dogs, or primates. Effects on behavior can be captured on video using CCTV for dog and primate studies. Repeated administration and interaction studies can be performed. [Pg.744]

Figure 20. Influence of substitution with different halogens and halogen with methyl in the phenyl ring on blood pressure activity... Figure 20. Influence of substitution with different halogens and halogen with methyl in the phenyl ring on blood pressure activity...
Figure 22. Influence of bridge extension between the phenyl and the imidazoline ring on blood pressure lowering activity... Figure 22. Influence of bridge extension between the phenyl and the imidazoline ring on blood pressure lowering activity...
Azizi, M., Guyene, T. T., ChateUier, G., Wargon, M., and Menard, J. (1997) Additive effects of losartan and enalapril on blood pressure and plasma active renin. Hypertension. 29, 634-640. [Pg.170]

Figure 22.12 Regulation of actin-myosin interaction in smooth muscle via the light-chain kinase and phosphatase and effect on blood pressure. ions bind to calmodulin and the complex stimulates the conversion of inactive myosin light chain kinase (MLCK) to active MLCK which then phosphorylates the light chain. This results in activation of the cross-bridge cycle. The overall effect is vasoconstriction of the arteriole, which increases blood pressure. Figure 22.12 Regulation of actin-myosin interaction in smooth muscle via the light-chain kinase and phosphatase and effect on blood pressure. ions bind to calmodulin and the complex stimulates the conversion of inactive myosin light chain kinase (MLCK) to active MLCK which then phosphorylates the light chain. This results in activation of the cross-bridge cycle. The overall effect is vasoconstriction of the arteriole, which increases blood pressure.
The N-acetyl-y-glutamyl pro-drug of the hydralazine-hke vasodilator CGP 18137 showed a higher renal-selective activity than the parent compound, CGP 18137. In contrast to the parent drug, the pro-drug caused a decrease in renal resistance without any effect on blood pressure [49]. [Pg.133]

Gefarnate, a mixture of stereoisomers, was shown to lack both water-retaining and diuretic activity, to have no effect on blood pressure, respiration, blood-sugar. [Pg.48]

B. Since GABA is an inhibitory neurotransmitter, agents that potentiate its action are likely to be CNS depressants with sedative activity. GABA has no significant effect on blood pressure and will decrease the incidence of seizures. It has no direct ability to relieve pain. [Pg.289]

Effect of coffee on blood pressure and CA065 activity rennin-angiotensin-aldoster-one system and catecholamines concentration in patients with essential hypertension. Polski Merkuriusz CA066 Lekarski 1999 7(40) 159-163. [Pg.187]

Valproate has antiepileptic efficacy in different types of epilepsy. It is therefore sometimes called the hroad range antiepileptic drug. It has no significant hypnosedative effects nor does it have respiratory depressant activity. In addition it does not have undesirable effects on blood pressure, heart rate, kidney function and body temperature. [Pg.108]

The effects of sympathomimetic drugs on blood pressure can be explained on the basis of their effects on heart rate, myocardial function, peripheral vascular resistance, and venous return (see Figure 6-7 and Table 9-4). The endogenous catecholamines, norepinephrine and epinephrine have complex cardiovascular effects because they activate both and 13 receptors. It is easier to understand these actions by first describing the cardiovascular effect of sympathomimetics that are selective for a given adrenoreceptor. [Pg.181]

Progestogens with a degree of mineralocorticoid activity will tend to cause water and salt retention and to increase blood pressure in susceptible subjects. However, effects on blood pressure can be variable for example, medroxyprogesterone has been variously reported to cause a fall in blood pressure in some initially hypertensive patients while rapidly increasing diastolic pressure in some other women, or to have no effect on blood pressure at all. [Pg.290]

In spite of the fact that phenol oxidase probably plays no important role in the inactivation of pressor amines in the body, it has been reported that the injection of the enzyme into hypertensive rats led to a reduction in their blood pressure (141,143)- It is difficult to assess the value of these experiments because of the nonspecific depressor effects of crude protein preparations on blood pressure. For example, Prinzmetal et al. (126) found that their tyrosinase preparations inactivated by boiling decreased the blood pressure of hypertensive patients as well as did their enzymically active preparations. [Pg.51]

Cholinesterase inhibitors have less marked effects on vascular smooth muscle and on blood pressure than direct-acting muscarinic agonists. This is because indirect-acting drugs can modify the tone of only those vessels that are innervated by cholinergic nerves and because the net effects on vascular tone may reflect activation of both the parasympathetic and sympathetic nervous systems. The cholinomimetic effect at the smooth muscle effector tissue is minimal since few vascular beds receive cholinergic innervation. Activation of sympathetic ganglia may increase vascular resistance. [Pg.142]

It is important to realize how difficult it is to define the in vivo inhibition of ACE. The enzyme may be explored for its N-terminal active sites by measurement of a constant and maximally increased level of N-acetyl SDKP in plasma and urine (211), but the residual activity of the C-ter-minal sites is probably not being measured. The methods for in vitro measurement of plasma ACE, except perhaps that described by Nuss-berger et al. (256), do not appropriately quantify global ACE inhibition. Moreover, the consequences of enzyme blockade are modified by secondary activation of the RAS (233). Residual amounts of angiotensin II secondary to a reactive rise in renin and angiotensin I may explain why the administration of an angiotensin II antagonist still has an additive effect on blood pressure and possibly on the heart, the vessels, and the kidney when added to certain doses of ACE inhibitors (228, 229, 257). [Pg.44]


See other pages where Activity on blood pressure is mentioned: [Pg.42]    [Pg.83]    [Pg.408]    [Pg.223]    [Pg.117]    [Pg.42]    [Pg.83]    [Pg.408]    [Pg.223]    [Pg.117]    [Pg.129]    [Pg.362]    [Pg.514]    [Pg.690]    [Pg.142]    [Pg.348]    [Pg.17]    [Pg.71]    [Pg.49]    [Pg.82]    [Pg.162]    [Pg.164]    [Pg.225]    [Pg.626]    [Pg.112]    [Pg.55]    [Pg.14]    [Pg.111]    [Pg.209]    [Pg.107]    [Pg.410]    [Pg.204]   
See also in sourсe #XX -- [ Pg.670 ]




SEARCH



Blood activity

Blood pressure

© 2024 chempedia.info