Actinomycetes marine-derived

Magarvey NA, JM Keller, V Bernan, M Dworkin, DH Sherman (2004) Isolation and characterization of novel marine-derived actinomycete taxa rich in bioactive metabolites. Appl Environ Microbiol 70 7529-7530. 

Sitachitta, N. Gadepalli, M Davidson, B.S. (1996) New a-pyrone-containing metabolites from a marine-derived actinomycete. Tetrahedron, 52, 8073-80. 

Liu R, Zhu T, Li D, Gu J, Xia W, Fang Y, et al. Two indolocarbazole alkaloids with apoptosis activity frcm a marine-derived actinomycete. Arch Pharmacol Res 2007 30 270-4. 

Fu P, Wang SX, Hong K, Liu PP, Wang Y, Zhu WM (2011) Cytotoxic bipyridines from the marine-derived actinomycete actinoalloteichus cyanogriseus WHl-2216-6. J Nat Prod 74 1751-1756... 

Liu C, Lu Y, Yang Z, Xing Y, Xi T (2010) Rapid screening rmd cheuacterization of metabolites from a marine-derived actinomycete by high performance liquid chromatography coupled with electrospray ionization quadmpole time-of-flight mass spectrometry. Rapid Commun Mass Spectrom 24(23) 3413-3418. doi 10.1002/rcm.4744... 

Asolkar, R.N., Jensen, P.R., Kauffman, C.A., and Fenical, W. (2006) Daryamides A-C, weakly cytotoxic polyketides from a marine-derived actinomycete of the genus Streptomyces strain CNQ-085./. Nat. Prod., 69, 1756-1759. 

Cho, J,Y, Williams, P,G, Kwon, H.C., Jensen, P.R., and Fenical, W. (2007) Lucentamycins A-D, cytotoxic peptides from the marine-derived actinomycete Nocardiopsis lucentensis. J. Nat Prod., 70, 1321-1328. 

Iwata, F., Sato, S., Mukai, T., Yamada, S., Takeo, J., Abe, A, Okita, T, and Kawahara, H. (2009) Lomeic adds, trialkyl-substituted aromatic acids from a marine-derived actinomycete. /. Nat. Prod., 72, 2046-2048. 

Perez, M., Crespo, C., Schleissner, C., Rodriguez, P., Zuniga, P., and Reyes, F. (2009) Tartrolon D, a cytotoxic macrodiolide from the marine-derived actinomycete Strcptomyccs sp. MDG-04-17-069. J. Nat. Prod., 72, 2192-2194. 

Sugiyama, Y. and Hirota, A. (2009) New potent DPPH radical scavengers from a marine-derived actinomycete strain USF-TC31. Biosci. Biotechnol. Biochem., 73, 2731—2734. 

Reed KA, Manam RR, Mitchell SS, Xu J, Teisan S, Chao T-H, Deyanat-Yazdi G, Neuteboom STC, Lam KS, Potts BCM (2007) Salinosporamides D-J from the Marine Actinomycete Salinispora tropica, Bromosalinosporamide, and Thioester Derivatives Are Potent Inhibitors of the 20S Proteasome. J Nat Prod 70 269... 

Martin GDA, Tan LT, Jensen PR, Dimayuga RE, Fairchild CR, Raventos-Suarez C, Fenical W (2007) Marmycins A and B, Cytotoxic Pentacyclic C-Glycosides from a Marine Sediment-Derived Actinomycete Related to the Genus Streptomyces. J Nat Prod 70 1406... 

The 36 late stage compounds are being developed predominantly in the oncology (twenty compounds) and antibacterial (nine compounds) therapeutic areas, as well as for the treatment of diabetes (three compounds), multiple sclerosis (MS) (two compounds), pain relief (one compound) and cardiovascular disease (one compound). There are 25 unique lead compounds of which 12 are derived from microorganisms (six actinomycetes, four fungi, one myx-obacterium and one bacterium), nine from plants, two from marine sponges and two from mammals (one bovine and one lizard). 

In this chapter, we highlight the unique aspects of developing a marine actinomycete-derived therapeutic agent, NPI-0052, as we chronicle events from the early mechanism of action and preclinical studies that supported its entry into clinical trials in cancer patients, to the current strategy for its continued development as an anticancer agent. 

The indolocarbazole alkaloids and the biosynthetically related bisindolylmaleiraides constitute an important class of natural products, which have been isolated from actinomycetes, cyanobacteria, slime molds, and marine invertebrates [1-3], They display a wide range of biological activities, including antibacterial, antifungal, antiviral, hypotensive, antitumor, and/or neuroprotective properties. The antitumor and neuroprotective activities of indolocarbazoles are the result of one, or several, of the following mechanisms (a) inhibition of different protein kinases, (b) inhibition of DNA topoisomerases, or (c) direct DNA intercalation [3-6], Hundreds of indolocarbazole derivatives have been produced by chemical synthesis or semisynthesis [1,2,6], and several of them have entered clinical trials for the treatment of diverse types of cancer, Parkinson s disease or diabetic retinopathy [3,7]. 

A new dibenzodiazepine alkaloid, diazepinomicin 265, was isolated from the culture of a marine actinomycete of the genus Micromonospora Compound 265 showed modest anti-microbial activity against selected Gram-positive bacteria with MICs of about 32 pg mL". The method of expression the biosynthetic pathway genes in transformed host cells, and the novel polynucleotide sequences and their encoded proteins involved in the biosynthesis of 265 were discussed. Derivatives of 268 were prepared. ... 

Two new cyclic peptides 299 and 300 were isolated from the culture broth of an actinomycete of the genus Streptomyces isolated from an unidentified marine sponge, their structures were defined to be the dehydroxy and desmethylenyl derivatives of nocardamine, respectively. They exhibited weak inhibition against the enzyme sortase. 

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