Mold, slime

Batcho indole synthesis is a useful tool for synthesis of naniral products. As oudined in Scheme 10.6, the Batcho indole synthesis is used for total synthesis of the slime mold alkaloid arcyriacyanin. Such indolocarbazole alkaloids represent a growing number of naniral products isolated from soil organism, slime molds, and marine sources. They are important as andnimor compounds and protein kinase C and topoisomerase inhibitors. 

Nonmuscle/smooth muscle myosins-Il are structurally similar to striated muscle myosin-II, but they have slower rates of ATP hydrolysis than do their striated muscle counterparts. Nonmuscle/smooth muscle myosin-II is also regulated differently than striated muscle myosin-II. Nonmuscle myosin-II is divided into the invertebrate and vertebrate branches (Cheney et al., 1993). This group is ubiquitous because it is present in most lower organisms, such as slime molds, amoeba, sea urchins, etc., and in virtually all mammalian nonmuscle cells. Smooth muscle myosin-II is also somewhat heterogeneous in that at least three separate forms of smooth muscle heavy chains, with molecular weights of 196,000, 200,000, and 204,000 have been identified (Kawamoto and Adelstein, 1987). The physiological properties of these separate myosin heavy chains are not yet known. 

Adelman, M.R., Taylor, E.W. (1969). Further characterization of slime mold myosin and slime mold actin. Biochemistry, 8, 4976-4988. 

Poly(L-malate) [poly(malic acid) (PMA)], is a water-soluble polyanion produced by slime molds and some yeasts such as Physarum polycephalum or Aureobasidium pullulans, respectively. Its function and metabolism has been studied during the last few years [122-125]. Recently, several PMA-degrad-ing bacteria have been isolated, and a cytoplasmic membrane-bound PMA hydrolase was purified from Comamonas acidovans strain 7789 [126] that... 

Four isoforms of PLC ((3, y, 8 and e Fig. 20-3) have been identified in the brain, with the nomenclature based upon the chronology of their discovery. The a isoform was subsequently identified as a proteolytic fragment of PLC8 (for reviews, see [10,11]). Because the lower eukaryotes such as yeast and slime molds possess only the 8 isoform, it has been suggested that the other isoforms evolved... 

Li+ causes malformation and affects regeneration in some protozoans, for example Tetrahymenapyriformis [231], by inhibiting both DNA and RNA synthesis by affecting regeneration in Hydra [232], planarians [233], and annelids [234] and by affecting cell signaling mediated by both inositol phosphate metabolism [235] and adenylate cyclase [236] in slime molds. 

GEL Sec23p and Sec24p Slime mold villin GEL PSI-BLAST (3) 6 X 10 4 A. thaliarm Sec23p... 

Theoretical models shed light on additional aspects of pulsatile cAMP signaling in Dictyostelium. First, like Ca + spikes, cAMP pulses are frequency encoded. Only pulses delivered at 5-min intervals are capable of accelerating slime mold development after starvation. Simulations indicate that frequency encoding is based on reversible receptor desensitization [76]. The kinetics of receptor resensitization dictates the interval between successive pulses required for a maximum relay response [78]. Second, cAMP oscillations in... 

Kanoh, F. Ozone reaction on slime mold. Tokyo Toritsu Eisei Kenyssho Kenkyu Nempo 24 337-342, 1972. (in Japanese)... 

Newel PC, Aggregation and cell surface receptors in cellular slime molds. In Cuatrecasas P, Greaves ME (eds.). Receptors and Recognition, pp. 1—58, 1977. 

The majority of indolocarbazole alkaloids, isolated so far from nature, are derivatives of the indolo[2,3-fl]pyrrolo[3,4-c]carbazole ring system 292. They have been isolated from soil organisms, slime molds, and marine sources (3,7,8,252-255), and have shown a broad range of potent biological activities, such as antifungal, antimicrobial, antitumor, and antihypertensive activity (3,7,256-260,267-270). Their activity as potent inhibitors of protein kinase C (PKC) has received special attention, and was the focus of several investigations (8,257,258,271-280). The history of these natural products dates back about 30 years (Scheme 2.73). 

These studies demonstrate the general mechanism of synchronization of biochemical systems, which I expect to be operative in even more complex systems, such as the mitochondrial respiration or the periodic activity of the slime mold Dictyostelium discoideum. As shown in a number of laboratories under suitable conditions mitochondrial respiration can break into self-sustained oscillations of ATP and ADP, NADH, cytochromes, and oxygen uptake as well as various ion transport and proton transport functions. It is important to note that mitochondrial respiration and oxidative phosphorylation under conditions of oscillations is open for the source, namely, oxygen, as well as with respect to a number of sink reactions producing water, carbon dioxide, and heat. 

Kamo et al. [Biochim. Biophys. Acta, 367, 1 and 11 (1974)] have shown that nonionic sugars modify the zeta potential of slime mold cells. Aggregation of colloids is related to their surface charge and their surface potential. This fact shows evidence of long-range electrostatic interactions controlled by metabolic reactions taking place at the membrane and able to modify the composition of the membrane medium interface. In this process the diffusion is not relevant, as indicated by Mrs. Babloyantz. 

Plasmodial slime molds (Myxomycetes) are eukaryotic bacteriovores usually occurring in terrestrial ecosystems. Although a few species appear to be confined to the tropics or subtropics, the majority are cosmopolitan and approximately 1000 species have been recognised. In the assimilative... 

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